Abstract Objective: To investigate the value of hysteroscopy combined with transvaginal ultrasound examination for diagnosing endometrial polyps of postmenopausal women. Methods: From June 2017 to March 2019, 673 postmenopausal women who underwent hysteroscopy because of abnormal uterine bleeding or endometrial thickening indicated by transvaginal ultrasound were included this study. The average age of these included women was 61.3±9.3 years old, and their average durational of menopause was 10.7±2.7 years. The efficacy of transvaginal ultrasound examination combined with hysteroscopy for diagnosing endometrial polyps was calculated based on the final pathological results as diagnosis gold standard. Results: 256 women with endometrial polyps were diagnosed by transvaginal ultrasound, 377 women with missed diagnosis, and 11 women were misdiagnosed. The sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and Yoden index of diagnosis by transvaginal ultrasound were 40.4%, 72.5%, 1.47, 0.82, and 0.13, respectively. 550 women with endometrial polyps were diagnosed by hysteroscopy combined with transvaginal ultrasound examination, 83 women with missed diagnosis, and 4 women were misdiagnosed. The sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and Yoden index of diagnosis by hysteroscopy combined with transvaginal ultrasound were 86.9%, 90.0%, 8.69, 0.15, and 0.77, respectively. Hysteroscopy combined with transvaginal ultrasound examination had increased the sensitivity, specificity, positive likelihood ratio, and yoden index, while had decreased negative likelihood ratio. Conclusion: Vaginal ultrasound examination combined with hysteroscopy for diagnosing endometrial polyps of postmenopausal women has more accurate and lower of missed diagnosis rate.
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