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Abstract Objective: To investigate the effect of laparoscopic myomectomy on angiogenesis, stress response, and immune function of patients with hysteromyoma. Methods: 90 patients with hysteromyoma were randomly divided into conventional group and observation group (45 cases in each group). The patients in the conventional group had undergone open surgery for myomectomy, and the patients in the observation group had undergone laparoscopic myomectomy. The changes of angiogenesis, stress response, and immune function of all patients were compared before and after surgery. Results: On the 1st and 3rd day after operation, the levels of EGF, VEGF, VEGFR2, ALD, AngⅡ, NE, CD3+, and CD8+ of patients in the two groups had increased significantly, but the levels of CD3+, CD4+, and CD4+/CD8+ of patients had decreased significantly (P>0.05). On the 1st day after operation, the levels of EGF, VEGF, VEGFR2, ALD, AngII, NE, and CD8+ of patients in the observation group were 2.85±0.82μg/L, 159.79±16.98pg/ml, 3764.82±380.32pg/mL, and 35.66±4.62%, respectively, which were significant lower than those of women in conventional group (P>0.05). On the 3rd day after operation, the levels of EGF, VEGF, VEGFR2, ALD, AngII, NE, and CD8+ of patients in the observation group were 2.08±0.49μg/L,130.63±15.73pg/ml, 3320.61±352.36pg/ml, and 30.37±3.62%, respectively, which were significant lower than those of women in conventional group (P>0.05). On the 1st day after operation, the levels of CD3+, CD4+, and CD4+/CD8+ of patients in the observation group were 44.75±6.27%, 29.18±3.71%, and 1.26±0.13 respectively, which were significant lower than those of women in conventional group (P>0.05). On the 3rd day after operation, the levels of CD3+, CD4+, and CD4+/CD8+ of patients in the observation group were 56.65±8.22%, 35.35±6.21%, and 1.38±0.15, respectively, which were significant lower than those of women in conventional group (P>0.05). Conclusion: Compared with those of patients who experinced traditional open surgery for myomectomy, laparoscopic myomectomy can reduce the stress response and immunosuppression of patients, and their angiogenesis related indicators of patients has less fluctuation with better overall curative effect.
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