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Abstract Objective: To investigate the effect of different luteal support methods on early threatened abortion, and to analyze its influence on pregnancy outcomes. Methods: 90 women with early threatened abortion were randomly divided into three groups, which included group A (30 women treated by intramuscular progesterone injection), group B (30 women treated by oral dydrogesterone), and group C (30 women treated by vaginal progesterone soft capsule). The levels of serum progesterone (P), estradiol (E2) and human chorionic gonadotropin (hCG) of women in the three groups were observed before and after treatment, and the success rate of fetal protection and pregnancy outcomes of women in the three groups were also observed. Results: The success rate of women in the three groups were 70.0%, 66.7%, and 76.7%, respectively, which had no significant different (P>0.05). The vaginal bleeding time of women in the three groups were 3.0±0.7d, 3.2±0.4d, 3.3 ± 0.5d, respectively , which had also no significant different (P>0.05). There were no significant different in the rates of perinatal placenta previa, placental abruption, premature rupture of membranes, full-term pregnancy, complete abortion, and missed abortionof women among the three groups (P>0.05). After treatment, the P level of women in group B was highest, and the level of E2 or hCG of women in group A was highest (P<0.05). Conclusion: Intramuscular progesterone injection, oral dydrogesterone, and vaginal progesterone soft capsule have all significant effect on fetal protection, which have the same influence on perinatal complications and pregnancy outcomes. Intramuscular progesterone injection can increase the levels of E2 and hCG of women with early threatened abortion, so it can be considered for using firstly.
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