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| The study on the association between elevated thyroid stimulating hormone level and body mass index of reproductive age women in Shenzhen |
| 1. National Research Institute for Family Planning, Beijing, 100081；2. Shenzhen Health Development Research Center；3. Graduate School of Peking Union Medical College |
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Abstract Objective: To explore the association between elevated thyroid stimulating hormone (TSH) level and body mass index (BMI) of reproductive age women in Shenzhen. Methods: A total of 256 675 reproductive age women who had participated in the National Pre-pregnancy Health Examination Program in Shenzhen from January 2013 to December 2018 were selected as the research objects. The relevant information about physical examination and laboratory examination of these research objects were collected by questionnaire. The multivariate logistic regression model was used to analyze the association between BMI and elevated TSH level of reproductive age women. Results: In these 256 675 reproductive age women, the women with elevated TSH level accounted for 3.39%, the women with underweight(BMI <18.5kg/m2) accounted for 20.03%, and the women with overweight/obese (BMI≥24.0kg/m2) accounted for 11.99%. The multivariate analysis showed that compared with those of women with normal TSH level, the risk of overweight/obese of women with elevated TSH level had increased by 29% (OR=1.29, 95%CI: 1.20-1.38), and the risk of underweight of women with elevated TSH level had decreased by 13% (OR=0.87, 95%CI: 0.82-0.93). Conclusion: Elevated TSH level of reproductive age women was positively associated with BMI increased, so keeping TSH level in an appropriate range might reduce the risk of overweight/obese of reproductive age women.
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