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| Levels of serum VEGF, IL-18 and MCP-1 of pregnant women with pregnancy induced hypertension and its relevant with hemorheology indexes |
| 1. Guangyang District Maternal and Child Health Care Hospital, Langfang, Hebei Province, 065900; 2. People's Hospital of Huanghua, Hebei Province |
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Abstract Objective: To investigate the relationship between the levels of serum vascular endothelial growth factor (VEGF), interleukin-18 (IL-18), and monocyte chemoattractant-1 (MCP-1) of pregnant women with pregnancy induced hypertension (PIH), and to study their relevant with hemorheology indexes. Methods: 125 pregnant women with PIH were enrolled in observation group, and another 103 normal pregnant women were selected in control group during the same period from April 2017 to May 2019. The levels of VEGF, IL-18 and MCP-1 were measured by ELISA, and blood rheology indexes were measured by ZL9000 blood rheometer. The serum VEGF, IL-18 and MCP-1 levels and hemorheology indexes of women were compared between the two groups. Pearson correlation analysis was used to analyze the relationship between the VEGF, IL-18, MCP-1 levels and hemorheology. Results: The levels of VEGF, IL-18 and MCP-1 of women in the observation group were significant higher than those of women in the control group (P<0.05). The values of high and low cut reduction viscosity of whole blood, cut viscosity of whole blood, plasma viscosity, erythrocyte aggregation index, fiber proteinogenlevel, and erythrocyte hematocrit of women in the observation group were significant higher than those of women in the control group (P<0.05). Correlation analysis showed that serum VEGF, IL-18 and MCP-1 levels were positively correlated with the values of high and low cut reduction viscosity of whole blood, cut viscosity of whole blood, and VEGF level was positively correlated with plasma viscosity. Conclusion: The levels of VEGF, IL-18 and MCP-1 of women with pregnancy-induced hypertension incerase, which are related closely to teir hemorheology indexes.
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