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| The influence of aspirin for treating women with early recurrent spontaneous abortion on their uterine hemodynamics and pregnancy outcomes |
| Yuxi People's Hospital, Yunnan Province, 653100 |
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Abstract Objective: To investigate the influence of aspirin for treating women with early recurrent spontaneous abortion (ERSA) on their uterine hemodynamics and pregnancy outcomes. Methods: 144 women with ERSA were selected in the study group, and 50 healthy women of childbearing age were selectedin the control group during the same period from March 2016 to July 2017. The women in the study group were treated with oral aspirin. The changes of uterine hemodynamic parameters, coagulation status of women in the study group before and after treatment, and pregnancy outcomes of all women were observed and recorded. Results: The endometrial thickness in the middle luteal phase of women in the study group before treatment was significant thiner than that of women in the control group (P<0.05), but the palsatility index (PI) of endometrial blood flow, mPI of uterine artery, mRI of uterine artery, and systolic/diastolic (mS/D) of uterine artery of women in the study group were significant higher than those of women in the control group (P< 0.05). After treatment, the values of PI, RI, S/D, and mPI, mRI, mS/D, elastogram parameters reaction time (R), kinetics of clot development (K), αangle, maximum amplitude (MA), and coagulation index (CI) of women in the study group had decreased significantly, but the values of PT, TT and APTT had increased significantly (P<0.05). 87.88% of women with ERSA in the study group had been out of danger from early abortion after treatment. Conclusion: Aspirin used for treating women with ERSA can significantly improve their uterine hemodynamic parameters, coagulation status, and pregnancy outcomes.
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