Objective: To evaluationthe of the biotoxicity on sperm of condom in the market mainstream. Methods: 1.0 ml sperm application liquid was added into the condom, and the number of oil droplets was counted after 3 minutes of oscillation. The sperm motility rate was measured after 5 minutes and 60 minutes respectively, and the sperm motility rate was compared with sperm in sperm application liquid non-contacted the condoms during the same time. Results: The sperm survival index of 18 in these 23 models condoms was less than 0.8 after 5 minutes of sperm contacted condom, and the sperm survival rate of these 23 models condoms was less than 0.8 after 60 minutes of sperm contacted condom. The number of oil droplets of condoms had gradually decreased or disappeared over time. Conclusion: 23 models condoms from 16 brands all have sperm toxicity, and the toxicity degree is related to the brand, condoms model, and time of sperm contacting condoms. When condoms used for human assisted reproductive technology (ART), it should be chosen condoms with no spermicide and oil-free, and sperm biotoxicity test of condom is necessary for help to choose the condom with low sperm biotoxicity.

2019 Vol. 27　(6):　691- [Abstract]（ 308 ） HTML (0 KB)  PDF  (0 KB)  ( 40 )

Objective: To investigate the clinical efficacy of progesterone combined with hysteroscopic surgery for treating women with multiple endometrial polyps, and to study the treatment of the operation on postoperative recurrence. Methods: 106 women with multiple endometrial polyps were randomly divided into two groups. The women in the study group (53 patients) were given progestogen pills orally administered for 10 days after hysteroscopic surgery, and the women in the control group (53 patients) were given hysteroscopic surgery only. The postoperative menstrual amount, the time of menstrual period, the hemoglobin level, the endometrial thickness, and the endometrial polyp recurrence rate of women were compared between the two groups. Result: After surgery, the postoperative menstrual amount, the time of menstrual period, and the endometrial thickness were decreased significantly and hemoglobin level increased significantly (P<0.05). 3 months, 6 months, and 12 months after treatment, the menstrual amount and the time of menstrual cycle of women in the study group were significant shorter than those of women in the control group (P<0.05), the hemoglobin level was significant higher (P<0.05), the endometrial thickness was significant lower (P<0.05), and the menstrual improvement rate was significant higher (P<0.05). The recurrence rates of women in the study group (5.7% and 13.2%) at 6 months and 12 months after treatment were significant lower than those (22.6% and 30.2%) of women in the control group (P<0.05). There were no significant differences in pregnancy rate after treatment (64.7% vs. 65.7%, P>0.05) and the adverse reaction rate (3.8% vs. 0.0%, P=0.153) between the two groups. Conclusion: Progesterone combined with hysteroscopy for treating women with multiple endometrial polyps can significantly improve the menstruation situation of women, reduce the endometrial thickness, inhibit recurrence, and do not increase the risk of complications, which has better efficacy than that of treatment by hysteroscopy alone.

2019 Vol. 27　(6):　698- [Abstract]（ 347 ） HTML (0 KB)  PDF  (0 KB)  ( 39 )

Objective: To analyze the clinical efficacy of Danggui shaoyao powder and Shoutai pill for treating pregnant women with fetal death. Methods: From January 2016 to May 2018, 400 pregnant women with fetal death were enrolled and were randomly divided into the study group and the control group (200 cases in each group). The women in the control group were treated by conventional western medicine, and the women in the study group were treated by Danggui shaoyao powder combined with Shoutai pill. The treatment efficacy was compared between the two groups. Results: 2-3 months after treatment, the effective rate of women in the study group was 85.0%，which was significant higher than that of women (55.0%) in the control group (P<0.05). After treatment, the endometrial thickness and the levels of resume estradiol and progesterone of women had significantly increased in both groups, and those of women in the study group were better than those of women in control group. The VEGF level of women in the study group (120.8±8.5 pg/ml) was significant higher than that (113.3±7.4 pg/ml) of women in control group (P<0.05). Conclusion: Danggui shaoyao powder combined with Shoutai pill can significantly improve the physique of pregnant women with fetal death，and can help to repair their endometrial injury，which has efficacy and can be clinical application.

2019 Vol. 27　(6):　706- [Abstract]（ 403 ） HTML (0 KB)  PDF  (0 KB)  ( 35 )

Objective: To analyze the relationship between levels of serum folic acid and vitamin E and endothelial injury and oxidative stress of pregnant women with preeclampsia. Methods: The pregnant women with preeclampsia were selected and divided into group A (women with mild preeclampsia) and group B (women with severe preeclampsia) according to the severity of preeclampsia, and another healthy pregnant women were selected into the control group. The levels of serum folic acid and vitamin E, vascular endothelial damage index, such as soluble endothelial cell factor (sEng), soluble vascular endothelial growth factor receptor (sFlt-1), endothelin 1 (ET-1), vascular endothelial growth factor (VEGF) , and oxidative stress indicators, such as advanced protein oxidation product (AOPPs), lipid peroxide (LHP), total antioxidant capacity (T-AOC) were detected. Results: The levels of folic acid and vitamin E of women in group B were the lowest, but those of women in the control group were the highest. The levels of sEng and sFlt-1 of women in group B were the highest, but those of women in the control group were the lowest (P<0.05). Comparing with those of women in the control group, the levels of ET - 1, VEGF of women in group A and B were significant increased (P<0.05), but there were no significant difference between group A and group B (P>0.05). The levels of serum AOPPs and LHP of women in group B were the highest, but those of women in the control group were the lowest (P<0.05). The level of serum T-AOC of women in group B were the lowest, but that of women in the control group was the highest (P<0.05). Folic acid and vitamin E levels of women in group A were negatively correlated with level of sflt-1, AOPPs and LHP (P<0.05), positively correlated with T-AOC level (P<0.05), and no -correlated with levels of sEng, ET-1 and VEGF (P>0.05). The levels of folic acid and vitamin E of women in group B were negatively correlated with levels of sEng, sFlt-1, AOPPs and LHP (P<0.05), positively correlated with TAOC level (P<0.05), and no correlated with ET-1 and VEGF levels (P>0.05). Conclusion: The deficiency of folic acid and vitamin E of pregnant women may be involved in the occurring and development of preeclampsia by vascular endothelial injury and oxidative stress of pregnant women.

2019 Vol. 27　(6):　713- [Abstract]（ 259 ） HTML (0 KB)  PDF  (0 KB)  ( 42 )

Objective: To observe the clinical effect of different doses of levothyroxine for treating pregnant women with subclinical hypothyroidism, and to analyze its influence on their pregnancy outcomes. Methods: 210 pregnant women with subclinical hypothyroidism were enrolled as research subjects, and were divided into were divided into low dose group, middle dose group, and high dose group from January 2016 to January 2018. The women in the low dose group were given 50 μg/d levothyroxine, the women in the middle dose group were given 100 μg/d levothyroxine, and the women in the high dose group were given 150 μg/d levothyroxine. The incidence of adverse drug reactions during treatment, the adverse pregnancy outcomes, and the perinatal complications was observed, and the levels of serum TSH, FT3, FT4 and folic acid were compared before and after treatment. Results: The serum TSH levels of women in the middle dose group and high dose group were significant lower than those of women in the low dose group, while serum folic acid level was significant lower than that of women in the low dose group (P=0.000). The incidence of adverse pregnancy outcomes and the perinatal complications of women in the middle dose group and the high dose group were significant lower than those of women in the low dose group (P<0.05). There were no significant difference in serum TSH and folic acid levels, and the incidences of adverse pregnancy outcomes and perinatal complications between the high dose group and the middle dose group after treatment (P>0.05). The incidence of adverse drug reactions of women in the low dose group and the middle dose group were significant lower than that of women in the high dose group (P<0.05). Conclusion: Compared with those of women who using low dose (50μg/d) and high dose (150μg/d) of levothyroxine, middle dose of levothyroxine (100μg/d) can effectively reduce the serum TSH level of pregnant women with subclinical hypothyroidism, promote folic acid synthesis, prevent adverse pregnancy events, improve pregnancy outcome, and reduce the incidence of adverse drug reactions, and has high safety, which is worthy of clinical application.

2019 Vol. 27　(6):　721- [Abstract]（ 332 ） HTML (0 KB)  PDF  (0 KB)  ( 37 )

Objective: To investigate the outcomes of glucose and lipid metabolism of women with gestational diabetes mellitus (GDM) after l year of delivery, and to explore its relationship with postpartum hypertension (PHP). Methods: 120 pregnant women with GDM were included into the GDM group and 120 normal pregnant women were included into the control group from January 2016 to June 2017. The situation of glucose and lipid metabolism and blood pressure of all included women were compared between antenatal women and postpartum women. The correlation between the abnormal glucose and lipid metabolism situation and postpartum HP rate of women with GDM was analyzed. Results: The rates of family history with diabetes mellitus or hypertension, the rate of insulin used during pregnancy, pre-pregnancy BMI and blood pressure (SBP and DBP) of women in the GDM group were significant higher than those of women in the control group (P<0.05). The levels of FPG, 1hPG, 2hPG, FINS, HOMA-IR, TC and TG of prenatal women in the GDM group were significant higher than those of women in the control group, the levels of HBCI and HDL-C were significant lower (P<0.05), while there was no significant difference in LDL-C level between the two groups (P>0.05). One year after delivery, the BMI, and levels of FPG, 2hPG, HOMA-IR, TC, TG, LDL-C, SBP and DBP of women in the GCM group were significant higher than those of women in the control group, the level of HDL-C was significant lower (P<0.05), but there were no significant differences in levels of FINS and HBCI between the two groups (P>0.05). One year after delivery, the incidences of abnormal glucose metabolism (AGM), abnormal lipid metabolism (ALM), HP, and overweight or obesity of women in the GDM group were 47.5%, 47.5%, 16.7% and 35.0%, respectively, which were significant higher than those of women (7.5%, 19.2%, 1.7% and 20.0%, respectively) in the control group (P<0.05). In the GDM group, the age, pre-pregnancy BMI, and rate of admission to SBP and DBP, postpartum AGM and ALM, and overweight or obesity of women with HP were significant higher than those of women without HP (P<0.05), but the compliance rate of diet and exercise, rate of medical nutrition therapy during pregnancy, and the rate of postpartum balanced diet and regular exercise were significant lower than those of women without HP (P<0.05). Pre-pregnancy BMI, the rate of abnormal SBP and DBP in hospital, and HOMA-IR, rates of postpartum AGM and ALM, and overweight or obesity rate were the risk factors for postpartum HP of women with GDM (P<0.05), while the balanced diet and regular exercise were the protective factors for them (P<0.05). Conclusion: Women with GDM have disorders of glucose and lipid metabolism during pregnancy and postpartum, which have potential risk for postpartum hypertension. Glucose and lipid metabolism disorder, abnormal blood pressure in hospital and HOMA-IR, and pre-pregnant and postpartum overweight or obesity may be the risk factors for postpartum hypertension.

2019 Vol. 27　(6):　729- [Abstract]（ 317 ） HTML (0 KB)  PDF  (0 KB)  ( 42 )

Objective: To investigate the incidence of mental disorders of pregnant women with one child during pregnancy, and to explore the risk factors influenced their pregnancy outcomes. Methods: A total of 1364 pregnant women with history delivery were selected randomly as subjects from Liangping district of Chongqing city, and their mental health situations were investigated by questionnaire. The risk factors of adverse pregnancy outcomes were analyzed. Results: Totals of 1294 women had completed the questionnaire, and there were 126 women with mental disorders (9.7%) during pregnancy. The relationship with mother-in-law or husband, abortion history, mode of delivery or high-risk pregnancy of the first child, and planed for the second child were related to the occurrence of mental disorders during pregnancy (P<0.05). Among these 126 pregnant women with mental disorders during pregnancy, 38 cases (30.2%) had adverse pregnancy outcomes, and age, the relationship with mother-in-law or husband, abortion history, high-risk pregnancy of the first child, and planned the second pregnancy were related to adverse pregnancy outcomes (P<0.05), and the relationship with husband, abortion history, and high-risk pregnancy of the first child were the independent risk factors affected the adverse pregnancy outcomes (P<0.05). Conclusion: The targeted measures should be formulated to reduce the incidence of mental disorders of pregnant women with one child during pregnancy and to improve the pregnancy outcomes.

2019 Vol. 27　(6):　738- [Abstract]（ 329 ） HTML (0 KB)  PDF  (0 KB)  ( 37 )

Objective: To explore the effect of levels of serum soluble endothelial factor (sEng) and asymmetric dimethylarginine (ADMA) on the development of placental blood vessels of women with preeclampsia during the first or the second pregnant trimester. Methods: The serum sample of pregnant women at 10-13 gestational weeks and 20-24 gestational weeks were collected, which included 36 women with preeclampsia and 50 normal pregnant women. The levels of serum sEng, ADMA, and Nitric Oxide (NO) were detected by enzyme-linked immunosorbent assay. All the pregnant women underwent uterine artery Doppler examination to measure the PI. Placentas of the pregnant women who delivered were given CT scan after placental veins and arterial perfusion. Then the AW4.6 image post-processing workstation was used to reconstruct the three-dimensional image of placental blood vessels. The levels of sEng and ADMA, and PI were compared between the two groups, and the placental weight, vascular perfusion, vascular branch and neonatal birth weight were also compared. The correlation between levels of serum sEng, ADMA, NO and the placental blood vessels were analyzed by Pearson linear correlation. Results: The median concentration of sEng of women with preeclampsia during 10-13weeks and 20-24weeks were 13.895ng/ml and 6.596ng/ml, and those of ADMA were 2.189μmol/L and 1.954μmol/L, which were all significant higher than those of women in the control group (P<0.001), while the levels of NO were 80.629μmol/L and 106.024μmol/L, which were significant lower than those of women in the control group (P<0.000). The placental weight, placental vein vascular perfusion, placental arterial vascular perfusion, placental vascular branch, and neonatal birth weight of women with preeclampsia were (467.15±46.99)g, (24.46±4.51)ml, (19.63±3.45)ml, (5.77±0.76), and (2857.69±396.90)g, respectively, which all were significant lower than those of women in the control group (P<0.05). The levels of sEng and ADMA of women during the first or the second pregnant trimester were negatively correlation to the placental weight, the indexes of the placental vessels, and the neonatal birth weight, while NO level was positively correlation to the placental weight, the indexes of the placental vessels, and the neonatal birth weight. Conclusion: The levels of serum sEng and ADMA of women with preeclampsia during the first or the second pregnant trimester increase, which lead to the level of NO decreases and may lead to the placenta vascular morphologic changes, then cause the occurrence of preeclampsia.

2019 Vol. 27　(6):　747- [Abstract]（ 289 ） HTML (0 KB)  PDF  (0 KB)  ( 45 )

Objective: To explore the possibility of simplifying the followed up procedure after medical abortion during the first trimester pregnancy through the analysis of the uterine recovery in different followed up time after medical abortion by misoprostol combined with mifepristone. Methods: A retrospective analysis was performed on 1536 women who received mifepristone combined with misoprostol for medical abortion during the first trimester pregnancy in 2018. Results: There were 456 (29.7%) women lost followed up, and another 1080 (70.3%) women had completed followed up. The average number of gravidity and parity of women who had lost followed up were 2.6, and 0.7, respectively, which were significant different from those (2.0 and 0.5) of women who had finished followed up (P=0.000). Among the 1080 women finished followed up, 992 (91.9%) cases with completed abortion, 48 (4.4%) cases with incomplete abortion, and 40 (3.7%) cases with abortion failure. In the 992 cases with completed abortion, 911 women had received the urine pregnancy test. And in women received the urine pregnancy test, 212 (23.3%) cases were negative urine pregnancy test 2 weeks after medical abortion and 428 (70.3%) cases were negative urine pregnancy test in 3 weeks followed up, the cumulative negative rate was 70.3%. Over 4 weeks followed up, 271 women were negative pregnancy test, and the cumulative negative rate was 100%. All the women were given B ultrasonography examination in 2, 3, 4 weeks followed up, and the rates of proportion of endometrial repair of women with negative urinary pregnancy test were high, which had statistical significant differences in different weeks followed up (P=0.000). There was high correlation between the time of negative urine pregnancy test and the identified endometrial repair time by B ultrasonography (r=0.84, P=0.010). Conclusion: 2 weeks after medical abortion，the high correlation of the time of negative urine pregnancy test with the identified endometrial repair time by B ultrasonography. Therefore, the initial following up time of women after medical abortion should be postponed by the information management, and the following up procedure should be simplified, which can reduce women returning to hospital and improve the acceptability of women for medical abortion.

2019 Vol. 27　(6):　756- [Abstract]（ 286 ） HTML (0 KB)  PDF  (0 KB)  ( 36 )

Objective: To investigate the relationship between sexes hormone binding globulin (SHBG) level and glycolipid metabolism of women with polycystic ovary syndrome (PCOS). Methods: 185 women with PCOS and 120 healthy women of childbearing age who were received physical examination during the same period were selected into the observation group and the control group, and women in the observation group were further divided into two subgroups according to the level of SHBG. The levels of serum SHBG, sex hormone, blood glucose and lipid of all included women were detected, and the relationship between SHBG and glycolipid metabolism was analyzed. Results: The levels of FAI, AND, DHEAS, TG, TC, ApoB, FPG, FINS and HOMA-IR of women with low SHBG level were significant higher than those of women with normal SHBG level, but the HDL-C and ApoA levels were significant lower than those of women with normal SHBG level (P<0.05). There were no significant different in the levels of FAI, AND, DHEAS, TG, TC, ApoB, FPG, FINS, HOMA-IR, HDL-C and ApoA between the normal women and the women with PCOS and normal SHBG level (P>0.05). Correlation analysis showed that the SHBG level of PCOS patients was positively correlated with the levels of HDL-C and ApoA, and was negatively correlated with the levels of DHEAS, AND, FAI, FINS, HOMA-IR and ApoB (P<0.05). Conclusion: The women with PCOS and low SHBG level are more likely to have abnormal glycolipid metabolism, and the decrease of SHBG level may be a risk factor for dyslipidemia of women with PCOS.

2019 Vol. 27　(6):　764- [Abstract]（ 392 ） HTML (0 KB)  PDF  (0 KB)  ( 40 )

Objective: To investigate the influence of GnRHa combined with laparoscopic for conservative treating infertility women with endometriosis (EMT) on the pregnancy outcomes. Methods: The data of 228 infertility women with EMT from July 2013 to July 2017were retrospective analyzed. According to different treatment schemes, the women in the observation group (114 cases) were treated by laparoscopic conservative therapy combined with GnRHa, while the women in the control group (114 cases) were only treated by laparoscopic conservative therapy. r-AFS staging was performed for all included women. The serum levels of carcinoembryonic antigen 125 (CA125) of all women were monitored before and 1, 3, 6, 12 month after operation. After followed up for 36 months, the pregnancy rate and pregnancy outcomes of women were recorded. Results: The rates of stage Ⅲ and Ⅳ r-AFS, pregnancy rate, and term delivery rate of women in the observation group were higher than those of women in the control group, and the abortion rate was lower, but there were no significant different between the two groups (P>0.05). There were no significant difference in the rates of ectopic pregnancy and preterm birth, and mode of delivery between the two groups (P>0.05). After operation, the level of CA125 of all women had decreased significantly (P<0.05), and that of women in the observation group was significant lower than that of women in the control group at 1, 3, and 6 months after operation (P<0.05). The recurrence rate of EMT was 4.4% of women in the observation group, which had no significant different from that (7.9%) of women in the control group (P>0.05). Conclusion: Conservative laparoscopic therapy combined with GnRHa can improve the success pregnancy rate of infertility women with moderate and severe EMT, and 6-12 months after treatment is a critical period for pregnancy, which is helpful to optimize the quality of follicles and embryos, and to improve the pregnancy outcomes by improving pelvic environment and ovarian function.

2019 Vol. 27　(6):　772- [Abstract]（ 302 ） HTML (0 KB)  PDF  (0 KB)  ( 40 )

Objective: To analyze the reference value of serum placental growth factor (PLGF) level for prenatal screening of Down's syndrome (DS) of pregnant women during the first trimester pregnancy. Methods: From October 2017 to October 2018, 1806 pregnant women who were been screened DS during the first trimester pregnancy were selected as subjects, which included 48 pregnant women with high risk of DS were in the study group, and the other 1758 pregnant women were in the control group. The levels of serum PLGF, AFP, β-hCG, and PAPP-A of women in the two groups were examined and compared, and the diagnostic sensitivities of these indicator were compared. Results: The PLGF level of women (68.25±4.58 pg/mL) in the study group was significant lower than that (109.58±8.69 pg/mL) of women in the control group (P<0.05), but there were no significant differences in the levels of AFP, β-hCG and PAPP-A of women between the two groups (P>0.05). The AOC area of level of PLGF combined with levels of AFP, β-hCG, and PAPP-A for diagnosing women with high risk of DS during the first trimester pregnancy was significant higher than that of PLGF level, AFP level, β-hCG level, or PAPP-A level only (P<0.05). Conclusion: The maternal serum PLGF level is a sensitive indicator for DS screening during the first trimester pregnancy, it is worthy of clinical used for early screening DS by serum PLGF level combined with other conventional serological markers.

2019 Vol. 27　(6):　780- [Abstract]（ 305 ） HTML (0 KB)  PDF  (0 KB)  ( 39 )

Objective: To compare the clinical application value between non-invasive DNA prenatal testing technology (NIPT) and traditional maternal serum screening (SS) for Down's syndrome (DS) screening. Methods: 2217 pregnant women who underwent prenatal examination were selected as subjects from July 2014 to July 2017. All of them were received maternal SS and NIPT for DS screening during the second trimester pregnancy. All included women were followed up to 42 days after delivery. The results were compared between the two screening methods. Results: 41 (1.85%) cases with DS high risk were found by SS, and 19 (0.86%) cases with DS high risk were found by NIPT, and 21 (0.95%) cases were confirmed with abnormal chromosome aneuploidy after delivery. The positive detection rate, the false positive rate, the positive predictive rate, the negative predictive rate, and the specificity of SS were 81.0%, 58.5%, 41.5%, 99.8%, and 81.0%, and 98.9%, respectively. The positive detection rate, the false positive rate, the positive predictive rate, the negative predictive rate, and the specificity of NIPT were 90.5%, 0.0%, 100.0%, 99.9%, 90.5%, and 100.0%. Conclusion: As for DS screening, NTPT is more accurate and higher specificity with higher positive detection rate when compare to those of SS, which can reduce the probability of invasive prenatal examination and false labor, so it is worthy of promoting.

2019 Vol. 27　(6):　786- [Abstract]（ 328 ） HTML (0 KB)  PDF  (0 KB)  ( 39 )

Objective: To explore the clinical efficacy and causes of failure of Bakri uterine tamponade with balloon catheterization. Methods: The clinical data of 102 women with refractory postpartum hemorrhage from August 2016 to August 2018 were retrospective analyzed, and all women had undergone Bakri uterine tamponade with balloon catheterization. The women with successful hemostasis were included in group A, and women with failed hemostasis were included in group B. The general data and surgical conditions of women were compared between the two groups, and the causes of hemostasis failure were analyzed further. Results: In the 102 women, 92 (90.2%) cases were successfully hemostasis and 10 (9.80%) were failed. Before the balloon placement, the average bleeding volume of women in the group A was significant less than that of women in the group B (P<0.05). The rates of transfusion, disseminated intravascular coagulation, and shock of women in the group A were significant lower than those of women in the group B (P<0.05). After balloon placement, the amount of bleeding in 2 hours and total bleeding amount of women in group A were significant less than those of women in group B (P<0.05). In the group B, there were 5 women with placenta implantation, I woman with balloon detachment, 2 women with insufficient injection, and 2 women with the disseminated intravascular coagulation and shock. Conclusion: Bakri uterine tamponade with balloon catheter used in women with refractory postpartum hemorrhage has high effectiveness and high success rate. Placenta implantation, balloon detachment, insufficient fluid injection, disseminated intravascular coagulation and shock failure to correcting maybe the causes of failure for Bakri uterine tamponade.

2019 Vol. 27　(6):　793- [Abstract]（ 311 ） HTML (0 KB)  PDF  (0 KB)  ( 37 )

Objective: To explore the influence of post abortion care (PAC) on the adverse psychology and contraceptive knowledge of women who experienced medical abortion. Methods: 60 women who experienced medical abortion were selected and divide into the observation group (n=31) and the control group (n=29) by random number table method from September 2017 to August 2019. The women in the control group were treated by routine health education, and the women in the observation group were treated by PAC. The effect after intervention, the adverse psychological score, the situation of contraceptive knowledge, and the incidence of abortion because of unwanted pregnancy again of women were compared between the two groups. Results: After the intervention, the rate of efficient after intervention (93.6%) in the observation group was significant higher than that (48.3%) in the control group (P<0.05). The adverse psychological score of all women had significantly decreased after intervention, and that ［(31.1±1.4) and (25.8±1.5)］ of women in the observation group the was significant lower than that［(39.1±1.9) and (37.7±1.7)］ of women in the control group (P<0.05). The rate of mastery contraceptive knowledge of women (96.7%) in the observation group was significant higher than that (69.0%) of women in the control group (P<0.05). the incidence of abortion because of unwanted pregnancy again of women (3.2%) in the observation group was significant lower than that (20.7%) of women in the control group (P<0.05). Conclusion: If the women are treated by PAC after medical abortion, it has significant effectiveness, which can effectively alleviate adverse psychology of women and promot their contraceptive knowledge levels.

2019 Vol. 27　(6):　801- [Abstract]（ 407 ） HTML (0 KB)  PDF  (0 KB)  ( 31 )

Objective: To investigate the application of real-time dynamic four-dimensional time-space correlation imaging (STIC) in the diagnosis of fetal cardiac malformation. Methods: From August 2017 to June 2018, 160 pregnant women who had accepted antenatal examination were enrolled in this study. All women were examined by two-dimensional ultrasound (TDU) and STIC, and the results were compared between the two examination methods. Results: Both the screening time and the image acquisition time of STIC for single fetal were significant less than those of TDU (P<0.05). In these 160 women, 7 women’s fetuses were diagnosed congenital heart malformation by pathology or by clinical diagnosis after born. Among them, 5 cases were detected by TDU (the detection rate was 71.4%) and 2 cases were missed (the rate of missed diagnosis was 28.6%), and there was no misdiagnosed case. And 7 cases were all detected by STIC (the detection rate was 100%, and there was no any case missed or misdiagnosed). The detection rate by STIC was significant higher than that by TDU (P<0.05). As for normal fetuses, the total satisfaction of the examination of fourchamber heart, right ventricular outflow tract, and left ventricular outflow tract by STIC had no significant different from by TDU (P>0.05). Conclusion: STIC used for diagnosing fetal cardiac malformation has good detection rate, which can obtain high quality standard diagnostic section of fetal heart.

2019 Vol. 27　(6):　807- [Abstract]（ 318 ） HTML (0 KB)  PDF  (0 KB)  ( 36 )

Objective: To analyze the influence of pre-pregnancy overweight or obesity on glycolipid metabolism of pregnant women and pregnancy outcomes, and to provide evidence for scientific management of pregnant women with prepregnancy overweight or obese. Methods: From August 2016 to May 2017, 115 pregnant women with overweight or obese and without other diseases before pregnancy were randomly selected into the observation group, and another 235 pregnant women with normal body mass index (BMI) before pregnancy were selected into the control group during the same period. The glycolipid metabolism of pregnant women and maternal and child outcomes were compared between the two groups. Results: The rates of pregnancy induced hypertension, gestational diabetes, and postpartum hemorrhage of women in the observation group were 13.0%, 34.8%, and 17.4%, respectively, which were significant higher than those（6.4%, 17.5%, and 9.3%, respectively）of women in the control group (P<0.05), and the level of total cholesterol ［(5.9±1.0) nmol/L］ and low density lipoprotein level ［(2.7±0.7) mmol/L］ of women in the observation group during the third trimester pregnancy were significant lower than those ［(6.3±1.1)nmol/L and (3.0±0.8)mmol/L］ of women in the control group (P<0.05). The rates of macrosomia, neonatal Apgar score less than 10 points at 1 minute after born, and newborn transferred to NICU in the observation group was 13.3%, 6.1%, and 5.2%, respectively, which were significant higher than those in the control group (P<0.05), and the average birth weight of newborns in the observation group ［(3507.5±460.7)g］ was significant heavier than that of newborns in the control group (P<0.05). Conclusion: The women with overweight or obesity before pregnancy have higher rate of pregnancy induced hypertension and GDM than those women with normal weight before pregnancy, which may lead to more risk of adverse pregnancy outcomes.

2019 Vol. 27　(6):　814- [Abstract]（ 353 ） HTML (0 KB)  PDF  (0 KB)  ( 36 )