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Abstract Objective: To investigate the value of galectin-3 (Gal-3), midkine (MK) and Cytokeratin-18 (CK-18) expression for diagnosing thyroid cancer of women. Methods: The immunohistochemistry was used to detect the expression of Gal-3, MK and CK-18 of 100 women with thyroid nodules. According to the results of pathological diagnosis, the women were divided into the benign group (64 cases) and the malignant group (36 cases). The expression of Gal-3, MK and CK-18 in different thyroid nodules was compared. Based on the pathological results, the prognosis value of levels of Gal-3, MK, CK-18, or Gal-3 combined with MK and CK-18 for identifying thyroid cancer was analyzed. Results: The positive expression rates of Gal-3, MK and CK-18 of women in the malignant group were 100.0%, 94.4% and 91.7%, respectively, which were significant higher than those of women (21.9%, 18.8% and 15.6%, respectively) in the benign group (P<0.05). The sensitivity of Gal-3, MK, and CK-18 were 100.0%, 94.4%, and 91.8%, respectively, and the specificities were 78.2%, 81.3%, and 84.4%, respectively. Conclusion: The positive expression of Gal-3, MK and CK-18 of women with thyroid cancer has significantly higher, which has high diagnostic value for differential diagnosing benign or malignant thyroid nodules.
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