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| Clinical study of plasma D-Dimer and vonWillebrand factor levels of pregnant women with early onset preeclampsia in western area of Guangxi |
| The Affiliated Hospital of Guangxi Youjiang Nationality Medical College, Guangxi Zhuang Autonomous Region, 533000 |
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Abstract Objective: To explore the levels of plasma D-Dimer (D-D) and vonWillebrand factor (vWF) of pregnant women with early onset preeclampsia in western area of Guangxi city, and to study its clinical significance. Methods: A total of 179 pregnant women with pregnancy induced hypertension were divided into group A (69 early onset preeclampsia) and group B (110 women with pregnancy induced hypertension), and another 85 normal pregnant women were selected into group C. 3mL of peripheral venous blood of all included women were extracted at 10-15+6 gestational weeks, and the levels of plasma D-D and vWF were measured and compared among the three groups. The predict value of plasma D-D and vWF levels for early onset preeclampsia were analyzed by ROC curve. Results: The values of SBP and DBP of women in group A were significant higher than those of women in group B and group C, and the neonatal birth weight and the 1 minute Apgar score were significant lower (P<0.05). The levels of D-D and vWF of women in group A were the highest, but those of women in group C were the lowest (P<0.05). In group A, levels of plasma D-dimer and vWF were no significant related to the neonatal birth weight, 1 minute Apgar score (P>0.05), but were positively correlated with values of SBP and DBP (P<0.05). The AUC of D-D level combined with vWF level for predicting early onset preeclampsia was 0.898, which was significant higher than that of D-D level (0.729) or vWF level (0.793) only. Conclusion: The plasma levels of D-D and vW of pregnant women with early onset preeclampsia significantly increased, and the detection of levels of D-D combined with vWF can improve the predictive value of pregnant women with early onset preeclampsia in western area of Guangxi city.
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