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Abstract Objective: To analyze the influence of pre-pregnancy overweight or obesity on glycolipid metabolism of pregnant women and pregnancy outcomes, and to provide evidence for scientific management of pregnant women with prepregnancy overweight or obese. Methods: From August 2016 to May 2017, 115 pregnant women with overweight or obese and without other diseases before pregnancy were randomly selected into the observation group, and another 235 pregnant women with normal body mass index (BMI) before pregnancy were selected into the control group during the same period. The glycolipid metabolism of pregnant women and maternal and child outcomes were compared between the two groups. Results: The rates of pregnancy induced hypertension, gestational diabetes, and postpartum hemorrhage of women in the observation group were 13.0%, 34.8%, and 17.4%, respectively, which were significant higher than those（6.4%, 17.5%, and 9.3%, respectively）of women in the control group (P<0.05), and the level of total cholesterol ［(5.9±1.0) nmol/L］ and low density lipoprotein level ［(2.7±0.7) mmol/L］ of women in the observation group during the third trimester pregnancy were significant lower than those ［(6.3±1.1)nmol/L and (3.0±0.8)mmol/L］ of women in the control group (P<0.05). The rates of macrosomia, neonatal Apgar score less than 10 points at 1 minute after born, and newborn transferred to NICU in the observation group was 13.3%, 6.1%, and 5.2%, respectively, which were significant higher than those in the control group (P<0.05), and the average birth weight of newborns in the observation group ［(3507.5±460.7)g］ was significant heavier than that of newborns in the control group (P<0.05). Conclusion: The women with overweight or obesity before pregnancy have higher rate of pregnancy induced hypertension and GDM than those women with normal weight before pregnancy, which may lead to more risk of adverse pregnancy outcomes.
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