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Abstract Objective: To investigate the relationship between sexes hormone binding globulin (SHBG) level and glycolipid metabolism of women with polycystic ovary syndrome (PCOS). Methods: 185 women with PCOS and 120 healthy women of childbearing age who were received physical examination during the same period were selected into the observation group and the control group, and women in the observation group were further divided into two subgroups according to the level of SHBG. The levels of serum SHBG, sex hormone, blood glucose and lipid of all included women were detected, and the relationship between SHBG and glycolipid metabolism was analyzed. Results: The levels of FAI, AND, DHEAS, TG, TC, ApoB, FPG, FINS and HOMA-IR of women with low SHBG level were significant higher than those of women with normal SHBG level, but the HDL-C and ApoA levels were significant lower than those of women with normal SHBG level (P<0.05). There were no significant different in the levels of FAI, AND, DHEAS, TG, TC, ApoB, FPG, FINS, HOMA-IR, HDL-C and ApoA between the normal women and the women with PCOS and normal SHBG level (P>0.05). Correlation analysis showed that the SHBG level of PCOS patients was positively correlated with the levels of HDL-C and ApoA, and was negatively correlated with the levels of DHEAS, AND, FAI, FINS, HOMA-IR and ApoB (P<0.05). Conclusion: The women with PCOS and low SHBG level are more likely to have abnormal glycolipid metabolism, and the decrease of SHBG level may be a risk factor for dyslipidemia of women with PCOS.
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