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Abstract Objective: To investigate the relationship between interleukin-33 (IL-33) level and spontaneous abortion occurred of patients with polycystic ovary syndrome (PCOS). Methods: From February 2016 to December 2017, 96 women with PCOS who had admitted to endocrinology department were enrolled in the study group. According to the pregnancy outcomes, they were divided into the spontaneous abortion group (30 cases) and the full-term pregnancy group (66 cases). Sixty healthy women who underwent physical examination during the same time were selected into the control group. The levels serum IL-33, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), sex hormones follicle stimulating (FSH), luteum hormone(LH), and testosterone (T) of all women were tested, and the correlation between IL-33 level of women and pregnancy outcomes were analyzed. Results: The body mass index (BMI), levels of serum IL-33, TNF-α, IL-6, IL-8, FSH, LH and T, and HOMA-IR index of women with PCOS were (25.5±4.6 kg/m2, (6.5±1.7) mIU/ m, (29.5±8.6) pg/ml, (20.6±9.0) pg/ml, (60.4±27.0) pg/ml, (10.5±3.6) mIU/ml, (0.7±0.2) ng/ml, (11.2± 3.5) ng/L, (2.5±1.7), respectively, which all were significant higher than those of women in the control group (P<0.05). There were no significant differences in BMI, HOMA-IR, and the levels of serum SH, LH and T of women between the spontaneous abortion group and the full-term pregnancy group (P>0.05), but IL-33 level was significant lower than that of women in the full-term pregnancy group (P<0.05). The levels of TNF-α, IL-6 and IL-8 of women with PCOS were significant higher than those of women in the control group (P<0.05). IL-33 level was positively correlated with BMI and T level (r=0.356, 0.402, P<0.05), was negatively correlated with TNF-αlevel (r=-0.302, P<0.05), and was no correlated with HOMA-IR, and levels of FSH, LH, IL-6 and IL-8(r = 0.209, 0.130, 0.175, -0.101, -0.162, P>0.05). Conclusion: IL-33 is associated with the pathogenesis of women with PCOS, and it maybe has protect the pregnancy outcomes of women with PCOS.
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