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| The relationship between levels of serum folic acid and vitamin E and endothelial injury and oxidative stress of pregnant women with preeclampsia |
| Fenghua District Maternal and Child Health Care Hospital of Ningbo City , Zhejiang Province, 315500 |
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Abstract Objective: To analyze the relationship between levels of serum folic acid and vitamin E and endothelial injury and oxidative stress of pregnant women with preeclampsia. Methods: The pregnant women with preeclampsia were selected and divided into group A (women with mild preeclampsia) and group B (women with severe preeclampsia) according to the severity of preeclampsia, and another healthy pregnant women were selected into the control group. The levels of serum folic acid and vitamin E, vascular endothelial damage index, such as soluble endothelial cell factor (sEng), soluble vascular endothelial growth factor receptor (sFlt-1), endothelin 1 (ET-1), vascular endothelial growth factor (VEGF) , and oxidative stress indicators, such as advanced protein oxidation product (AOPPs), lipid peroxide (LHP), total antioxidant capacity (T-AOC) were detected. Results: The levels of folic acid and vitamin E of women in group B were the lowest, but those of women in the control group were the highest. The levels of sEng and sFlt-1 of women in group B were the highest, but those of women in the control group were the lowest (P<0.05). Comparing with those of women in the control group, the levels of ET - 1, VEGF of women in group A and B were significant increased (P<0.05), but there were no significant difference between group A and group B (P>0.05). The levels of serum AOPPs and LHP of women in group B were the highest, but those of women in the control group were the lowest (P<0.05). The level of serum T-AOC of women in group B were the lowest, but that of women in the control group was the highest (P<0.05). Folic acid and vitamin E levels of women in group A were negatively correlated with level of sflt-1, AOPPs and LHP (P<0.05), positively correlated with T-AOC level (P<0.05), and no -correlated with levels of sEng, ET-1 and VEGF (P>0.05). The levels of folic acid and vitamin E of women in group B were negatively correlated with levels of sEng, sFlt-1, AOPPs and LHP (P<0.05), positively correlated with TAOC level (P<0.05), and no correlated with ET-1 and VEGF levels (P>0.05). Conclusion: The deficiency of folic acid and vitamin E of pregnant women may be involved in the occurring and development of preeclampsia by vascular endothelial injury and oxidative stress of pregnant women.
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