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| Characteristics of insulin secretion of pregnant women with gestational diabetes mellitus and the influence on the maternal and infant outcomes |
| The Fourth People's Hospital of Yuyao City, Zhejiang province, 315470 |
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Abstract Objective: To analyze the characteristics of insulin secretion in pregnant women with gestational diabetes mellitus (GDM), and to analyze the influence on the maternal and infant outcomes. Methods: The data of pregnant women were retrospective analyzed. According to OGTT results and insulin levels, the included women were divided into different groups. The characteristics of insulin secretion, insulin resistance, and islet beta cell function indexes of all women were analyzed, and the characteristics of insulin secretion, and maternal and infant outcomes were compared among the groups. Results: The blood glucose value and insulin levels, and HOMA-IR of women with GDM at G0, G60 and G120 time were significant higher than those of women with normal blood glucose (P<0.05), but the ISIcomp, MBCI and ΔI30/ΔG30 were significant lower (P<0.05). The incidence of macrosomia of women with their blood glucose level increased to peak at 120 min after OGTT was highest (P<0.05). There were no statistically significant differences in the incidence of hyperhydramnios, premature rupture of membranes, preterm delivery, and neonatal hypoglycemia among the three groups (P>0.05). Conclusion: The pregnant women with GDM whose insulin level increase to the peak and delay until 120min after glucose load, and the peak of insulin level is consistent with the trend of insulin resistance and decline of islet beta cells, which are all related to the degree of GDM. The delayed peak of insulin level may also increase the risk of macrosomia.
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