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| Clinical efficacy of progesterone combined with hysteroscopic surgery for treating women with multiple endometrial polyps and its effect on postoperative recurrence |
| Changxing county Matermal and Child Health Care Hospital, Zhejiang Province, 313100 |
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Abstract Objective: To investigate the clinical efficacy of progesterone combined with hysteroscopic surgery for treating women with multiple endometrial polyps, and to study the treatment of the operation on postoperative recurrence. Methods: 106 women with multiple endometrial polyps were randomly divided into two groups. The women in the study group (53 patients) were given progestogen pills orally administered for 10 days after hysteroscopic surgery, and the women in the control group (53 patients) were given hysteroscopic surgery only. The postoperative menstrual amount, the time of menstrual period, the hemoglobin level, the endometrial thickness, and the endometrial polyp recurrence rate of women were compared between the two groups. Result: After surgery, the postoperative menstrual amount, the time of menstrual period, and the endometrial thickness were decreased significantly and hemoglobin level increased significantly (P<0.05). 3 months, 6 months, and 12 months after treatment, the menstrual amount and the time of menstrual cycle of women in the study group were significant shorter than those of women in the control group (P<0.05), the hemoglobin level was significant higher (P<0.05), the endometrial thickness was significant lower (P<0.05), and the menstrual improvement rate was significant higher (P<0.05). The recurrence rates of women in the study group (5.7% and 13.2%) at 6 months and 12 months after treatment were significant lower than those (22.6% and 30.2%) of women in the control group (P<0.05). There were no significant differences in pregnancy rate after treatment (64.7% vs. 65.7%, P>0.05) and the adverse reaction rate (3.8% vs. 0.0%, P=0.153) between the two groups. Conclusion: Progesterone combined with hysteroscopy for treating women with multiple endometrial polyps can significantly improve the menstruation situation of women, reduce the endometrial thickness, inhibit recurrence, and do not increase the risk of complications, which has better efficacy than that of treatment by hysteroscopy alone.
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