Objective: To investigate the changes of oxidative stress (OS) and low-grade inflammatory of pre-pubertal rats with polycystic ovary syndrome (PCOS) induced by high-fat diet. Methods:  36 pre-pubertal female rats were randomly divided into group A and group B (18 case in each group). The rats in group A were given normal diet fed for 105 days, and the rats in group B were given high-fat diet fed for 105 days to construct PCOS animals’ model. The levels of superoxide dismutase (SOD), malondialdehyde (MDA), lipid peroxidation (LPO) in ovarian tissue and serum high-sensitivity C-reactive protein (hsCRP) of all rats were detected on 49th d, 77th d and 105th d, respectively. Results: In group B, the estrous cycle of rats had changed irregularly, their ovary weight were also increased significantly, and there were multiple cystic dilated follicles, small follicles and atresia follicles in ovarian tissue of them, and the number of cystic follicles, follicular diameter, theca layer thickness and corpus luteum had decreased significantly, and the levels of glucose tolerance, fasting insulin, HOMA-IR, QUICK, total cholesterol, estradiol (E2), progesterone (P) and testosterone (T) had also changed significantly (P<0.05). The SOD level of rats in group A was significant higher than that of rats in group B, but the levels of MDA, LPO and hsCRP of rats in group A were significant lower (P<0.05). In group B, the SOD level of rats was negatively correlated with their levels of MDA, LPO, hrCRP, HOMA-IR and fasting insulin, MDA level of rats was positively correlated with their levels of LPO, hrCRP and HOMA-IR (P<0.05), the LPO level of rats was positively correlated with their levels of hrCRP and T (P<0.05), and the hrCRP level of rats was positively correlated with their T level (P<0.05). Conclusion: The low-grade inflammation occurance in pre-pubertal rats with PCOS induced by high-fat diet is consistent with the disease development of PCOS, so it is suggested that OS and low-grade inflammation may also be associated with rat model with PCOS.

2019 Vol. 27　(12):　1574- [Abstract]（ 315 ） HTML (0 KB)  PDF  (0 KB)  ( 38 )

Objective: To explore the status and relative factors of unsafe sex among college students in Beijing, and to provide evidence for the development of targeted interventions. Methods: 1069 unmarried college students were selected from four project districts of the comprehensive prevention and treatment project for adolescent reproductive health care of Beijing by convenience sampling method. Reproductive health information, such as sexual behaviors and contraceptive methods, of college students were collected by self-designed questionnaires, and the relative factors of unsafe sex were analyzed. Results: The incidence of premarital sexual behavior of college students was 13.2%, and the incidence of the non-consensual in the initial sexual behavior was 10.9%. The proportion of college students without contraception and with improper contraception in the initial sexual behavior were 31.9% and 18.3%. The proportion of college students without contraception, with improper contraception, and with different sexual partner in the recent sexual behavior were 11.6%, 18.8%, and 25.7%. Multivariate analysis results showed, younger college students had higher risk of improper contraceptive methods usage in the initial and recent sexual behaviors (OR 3.631 and 2.807, 95%CI 1.600-8.240 and 1.146-6.879). Compared with male students, female students had higher risk of unwanted initial sexual behavior (OR=3.596, 95%CI 1.045-12.379). Conclusion: College students are facing serious problems in unsafe sex, and the younger or female college students should be paid attention to.

2019 Vol. 27　(12):　1585- [Abstract]（ 369 ） HTML (0 KB)  PDF  (0 KB)  ( 38 )

Objective: To compare the efficacy, safety and acceptability between China-recommended regimen and WHO-recommended regimen for termination of pregnancy up to 49 gestational days. Methods：Women aged 18-40 who requested termination of pregnancy up to 49 gestational days in 4 public hospitals from Beijing and Qiqihar’er were divided into 2 groups randomly, and the women received China-recommended regimen were in group A and the women received WHOrecommended regimen were in group B. All the women were accepted drugs administered and followed up according to the protocol of China or WHOrecommended regimen. Results：The complete abortion rate of women in group A was 87.7%, which was significant lower than that (81.3%) of women in group B (χ2=5.699，P<0.05) . The average day of vaginal bleeding of women after abortion in group A was 13.9 days, which was significant longer than that (11.8 days) of women in group B (t=2.956, P<0.01). There were no severe side-effects occurrence in both groups, and the rates of general side-effects, such as nausea, fatigue and low abdominal pain had no significant different between the two groups. The proportion of satisfactory, acceptability for side-effects, possibility to choose the regimen again, or recommending to others of women in group B had much higher. Conclusion：Comparing to that of China-recommended regimen, WHOrecommended regimen had more efficacy in termination of pregnancy up to 49 gestational days, but the safety is similar in the two regimens.

2019 Vol. 27　(12):　1595- [Abstract]（ 359 ） HTML (0 KB)  PDF  (0 KB)  ( 40 )

Objective: To investigate the clinical effects of drospirenone and ethinylestradiol tabletsⅡ (Yasyue) and estradiol (1 mg) and dydrogesterone tablets (Femoston) for treating women after induced abortion. Methods: 300 women after induced abortion were randomly divided into group A, B, and C (100 cases in each group). After abortion, all the women were treated with antimicrobial drugs to prevent infection and Cihang capsule to promote uterine recovery, and the women in group A were also given Yasyue (1 tablet daily for 28d)，the women in group B were given Femoston (1 tablet daily for 28d) , and the women in group C were not given any additional drug. The vaginal bleeding time, endometrium thickness, menstrual recovery time, and the incidence of uterine adhesion of women were compared among three groups. Results: The vaginal bleeding time of women in group A and B were 3.8±0.9d and 3.8±0.8d, which were significant shorter than that (4.5±1.5d) of women in group C (P<0.05). The time of menstrual recovery of women in group A and B were 27.5±1.0d and 29.3±0.6d, which were significant shorter than that (29.2±2.4d) of women in group C (P<0.05), and the time of menstrual recovery of women in group A was significant shorter than that of women in group B (P<0.05). 14 day after abortion, the thickness of endometrium of women in group B (5.2±1.6mm) was significant thicker than that (4.5±1.8 mm) of women in group C (P<0.05), and that of women in group A (3.6±1.4mm) was significant thinner than that (4.5±1.8 mm) of women in group C (P<0.05). 2 month after abortion, the number of uterine adhesion of women in group A and B were 0 case and 0 case, which were significant less than that (5 cases) of women in group C (P<0.05). Conclusion: Yasyue and Femoston can effectively shorten the bleeding time of women after abortion, promote menstrual recovery, and prevent the occurrence of uterine adhesion. Femoston can effectively repair the endometrium by increase its thickness, but it has no contraceptive effect, so
Yasyue is more suitable for post-abortion women.

2019 Vol. 27　(12):　1604- [Abstract]（ 1426 ） HTML (0 KB)  PDF  (0 KB)  ( 59 )

Objective: To investigate the value of fetal hemodynamic parameters by ultrasound for dignosing fetal distress caused by intrahepatic cholestasis during pregnancy (ICP). Methods: 100 normal pregnant women were selected in group A, and 200 pregnant women with ICP were were selected in group B (women with mild ICP) and in group C (women with severe ICP) from October 2017 to October 2018. The values of resistance index (RI), Pulsatility index (PI), and the ratio of systolic blood pressure and diastolic blood pressure (S/D) of UA and MCA of women were determined and compared among the three groups. The ROC curve was drawn by RI, PI and S/D of UA and MCA. Results: There was significant different in RI, PI and S/D of UA between the three groups. The value of RI, PI or S/D of UA of women in group C was the highest (P<0.05). The area under ROC curve of RI, PI or S/D of UA was over 0.7 (P<0.05). The sensitivity, specificity, and area under ROC curve of RI of UA were the highest. The value of RI, PI or S/D of MCA of women in group C was the highest (P<0.05). The area under ROC curve of RI, PI or S/D of MCA was over 0.8 (P<0.05). The sensitivity, specificity, and area under ROC curve of PI of UA were the highest. Conclusion: UA and MCA examination by ultrasound can be used for predicting fetal distress of women with ICP. The RI of UA and PI of MCA were more preferably used in clinical diagnose.

2019 Vol. 27　(12):　1610- [Abstract]（ 342 ） HTML (0 KB)  PDF  (0 KB)  ( 38 )

Objective: To investigate the influence of different surgical procedures under hysteroscopy on the expression of estrogen receptor and progesterone receptor and prognosis of women with endometrial polyp. Methods: 96 women with endometrial polyps were enrolled from January 2017 to January 2018, and were divided into 3 groups by random number table method (32 cases in each group). Women in group A had underwent hysteroscopic curettage, women in group B had underwent hysteroscopic electrotomy, and women in group C had underwent hysteroscopic electrotomy and were inserted levonorgestrel releasing intrauterine system (LNG-IUS) on the 3rd day of menstruation recorvery after operation. The rate of endometrial polyp recurrence, the expression of estrogen receptor and progesterone receptor, endometrial thickness, and postoperative complications rate of women were compared between the three groups. Results: The endometrial thickness and the expression of estrogen receptor and progesterone receptor of women in group C had significantly decreased after treatment (P<0.05), but there were no significant difference in the endometrial thickness and the expression of estrogen receptor and progesterone receptor of women in group A and group B after operation (P>0.05). The recurrence rate of women in group C was 3.1%, which was significant lower than that (25.0%) of women in group A and that (21.9%) of women in group B (P<0.05), and there was no significant difference in the recurrence rate of women between group A and group B (P>0.05). There were no significant difference in the incidences of vaginal bleeding and profuse menstrual volume of women among the three groups (P>0.05). Conclusion: LNGIUS inserted after hysteroscopic electrotomy can significantly decrease the recurrence rate of endometrial polyps, which maybe associated with reducing estrogen receptor and progesterone receptor expression and inhibiting endometrial hyperplasia.

2019 Vol. 27　(12):　1617- [Abstract]（ 374 ） HTML (0 KB)  PDF  (0 KB)  ( 41 )

Objective: To explore the value of serum N-terminal B-type natriuretic peptide (NT-proBNP) combined with Tei index for evaluating the left ventricular function of pregnant women with pregnancy-induced hypertension. Methods: 61 pregnant women with pregnancy-induced hypertension were selected in study group and 50 normal pregnant women were selected in control group. All included women were checked by echocardiography and their serum NT-proBNP level was detected. The women in the observation group were further divided into study group 1 (26 women with pregnancy-induced hypertension), study group 2(25 women with mild preeclampsia) and study group 3 (10 women with severe preeclampsia) according to the condition of pregnancy-induced hypertension. The values of Left ventricular end-diastolic diameter (LVIDd), left ventricular end-systolic diameter (LVIDs), right atrial diameter (RVDd), and left ventricular ejection fraction (LVEF), and Tei index value and serum NT-proBNP level of women were compared among the four groups. Pearson correlation analysis was used for evaluating the correlation of the serum NT-ProBNP level and Tei index value with the values of LVIDd, LVIDs, RVDd and LVEF. Results: The values of LVIDs, Tei index, and serum NTProBNP level of women in the study group were 30.28±5.6 2mm, 0.39±0.13, and 142.02±12.35 pg/ml,respectively, which were significant higher than those (26.35±3.51 mm, 0.21±0.05,86.25±6.97 pg/ml, respectively) of women in the control group, but LVEF value of women in the study group was 64.25±5.69%, which was significant lower than that(68.25±6.85%) of women in the control group (P<0.05).In the study group, the Tei index value and serum NT-ProBNP level had increased with the situation of pregnancy-induced hypertension became severity (P<0.05), but LVEF value had decreased (P<0.05). Pearson correlation analysis showed that serum NT-ProBNP level and Tei index value were positively correlated with LVIDd value (r=0.265, 0.273, P<0.05), and negatively correlated with LVEF (r=-0.625, -0.521, P<0.05). Conclusion: Serum NT-ProBNP level and Tei index value of women with pregnancy-induced hypertension have increased significantly, which are negatively correlated with left ventricular systolic function of pregnant women, so it maybe as an effective index for clinical monitoring left ventricular function.

2019 Vol. 27　(12):　1624- [Abstract]（ 318 ） HTML (0 KB)  PDF  (0 KB)  ( 35 )

Objective: To analyze the influence of dexamethasone combined with pituitrin for treating women with postpartum hemorrhage on the levels of RhoA and Rho associated coiled coil forming protein kinase(ROCK). Methods: 88 high risk pregnant women were selected as the research objects, and they were divided into control group(n=46) and research group(n=42) from June 2017 to December 2018 according to simple random method. The women in the control group were treated by dexamethasone, and the women in the research group were treated by dexamethasone combined with pituitrin. The hemostatic efficacy, postpartum bleeding volume, levels of RhoA, ROCK Ⅰ,and ROCK Ⅱ protein, blood pressure value, and heart rate before and after treatment, and adverse reactions rate of women were compared between groups. Results: The total effective rate and level of hemoglobin of women in the research group were 97.6% and 121.1±16.0g/L, which were signifficent higher than those (84.8% and 113.1±13.3g/L) of women in the control group (P<0.05). Volume of 2h and 24h postpartum blood loss, and postpartum bleeding rate of women in the research group were 172.0±23.2ml, 255.1±31.2ml, and 2.4%, which were signifficent lower than those (287.3±38.7ml, 340.2±45.3ml, and 15.2%) of women in the control group (P<0.05). The protein levels of RhoA, ROCK Ⅰ, and ROCK Ⅱ of women in the research group were 0.59±0.07 ng/ml, 0.40±0.06 ng/ml, and 0.38±0.05 ng/ml, which were signifficent higher than those of women in the control group (P<0.05). There were no significant different in the values of diastolic and systolic blood pressure, heart rate, and adverse reactions rate of women between the two groups (P>0.05). Conclusion: Dexamethasone combined with pituitrin can enhance uterine contraction, regulate RhoA and ROCK protein expression, prevent postpartum hemorrhage caused by uterine contraction, and has good safty.

2019 Vol. 27　(12):　1632- [Abstract]（ 277 ） HTML (0 KB)  PDF  (0 KB)  ( 43 )

Objective: To investigate the influences of programmed intermittent epidural bolus (PIEB) combined with patient-controlled epidural analgesia (PCEA) on Th1/Th2 Cytokine level and delivery outcomes of pregnant women. Methods: 216 pregnant women were randomly divided into group A (72 women were given PIEB only), group B (72 women were given PCEA only), and group C (72 women were given PIEB combined with PCEA) from January 2016 to December 2017. All women were injected into epidural mixture (0.125% Bupivacaine+0.4μg/ml Sufentanil). Women in group A were treated by PIEB (epidural mixture 10ml/pulse, 1 pulse/h), women in group B were treated by PCEA, and women in group C were treated by PIEB (epidural mixture 8ml/h, 1 pulse/h) combined with PCEA. The levels of serum cortisol, IL-1β and IL-10 were detected. VAS score of women at the end of latent period (T1), the mouth of the uterus completely opening (T2), and fetal delivery (T3) were recorded. The stage of labor, neonatal Apgar score, the delivery outcomes, and oxytocin usage of women were compared between the two groups. Results: After analgesia, the dasage of Bupivacaine and Sufentanil, the VAS scores at T2 and T3 of women in group A and group C were significant lower than those of women in group B (P<0.05). The active period time of the first stage and time of second stage of women in group C were significant shorter than those of women in group A and C (P<0.05). The levels of serum cortisol, IL-1β and IL-10 of all women in the three groups at T1 were significant lower than those of women at T3 (P<0.05). The levels of serum cortisol and IL-1β of women in group C were significant lower than those of women in group A and B, but the level of serum IL-10 of women in group C was significant higher (P<0.05). The rate of vaginal delivery or satisfaction of women in group C was highest, but the rate the vaginal device midwifery or oxytocin used when vaginal delivery was the lowest (P<0.05). Conclusion: PIEB combined with PCEA for labor analgesia can relieve labor pain, shorten the active period of the first stage and second stage of labor, and decrease the instrumental midwifery rate, and it also can improve the quality of labor analgesia by maintaining Thl/Th2 cytokine balance and obtain satisfactory results.

2019 Vol. 27　(12):　1640- [Abstract]（ 294 ） HTML (0 KB)  PDF  (0 KB)  ( 42 )

Objective: To explore influence of continuous positive airway through the nose for treating pregnant women with obstructive sleep apnea hypopnea syndrome (OSAHS) serum advanced oxidative protein products (AOPP), macrophage migration inhibitor (MIF), and interleukin 18 (Il-18). Methods: 70 pregnant women with OSAHS were selected and were divided into observation group (n=40) and the control group (n=30) by random number table from September 2015 to September 2017. The women in the observation group were given nasal continuous positive airway pressure, and the women in the control group were given oral orthotics. The clinical curative effect, serum AOPP, MIF, and IL-18 levels, the rate of apnea at night, apnea hypoventilation index (AHI), blood oxygen saturation, blood pressure and life quality before and after the treatment of women were compared between the two groups. Results: After treatment, the effective rate of women in the observation group was 92.5%, which was significant higher than that(73.3%) of women in the control group (P<0.05). The levels of serum AOPP, MIF and Il-18 of women in the two groups had decreased significantly after treatment, and the levels of serum AOPP, MIF and Il-18 of women in the observation group were significant lower than those of women in the control group (P<0.05). The AHI, minimum oxygen saturation, and maximum apnea time of women in both groups had improved significantly after treatment, and AHI and maximum apnea time of women in the observation group were significant lower than those of women in the control group, but lowest oxygen saturation of women in the observation group was significant higher (P<0.05). The values of systolic blood pressure, diastolic blood pressure, and mean arterial pressure of women in the observation group were significant lower than those of women in the control group (P<0.05) after treatment. After treatment, the quality of life scores of women in the two groups were significantly increased, and that of women in the observation group was significant higher than that of women in the control group (P<0.05). Conclusion: The continuous positive airway through the nose for treating pregnant women with OSAHS can achieve ideal clinical efficacy, which can alleviate the clinical symptoms and improve the quality of life of pregnant women.

2019 Vol. 27　(12):　1648- [Abstract]（ 291 ） HTML (0 KB)  PDF  (0 KB)  ( 45 )

Objective: To investigate the prevalence and risk factors of gestational diabetes mellitus (GDM) in Yili region of Xinjiang, and to analyze its influence on pregnancy outcomes. Methods: 4 hospitals in Yili region of Xinjiang were selected by systematic and cluster sampling method. Clinical data of 6434 pregnant women who attended prenatal care and delivered in these four hospitals were collected. GDM was diagnosed according to International Association of Diabetes and Pregnancy Study Groups (IADPSG).The disease characteristics of GDM were analyzed and the pregnancy outcomes of all included pregnant women were followed up. Results: The prevalence of GDM in Yili region was 6.6% (422/6434). The age≥35 years old, family history of diabetes mellitus, pre-pregnancy overweight or obesity, high education level, maternal, urban household registration, or mental work were the independent risk factor for GDM (P<0.05). The the delivery gestational weeks of women with GDM was earlier than that of women without GDM (P<0.05). The rates of cesarean section, premature labor, anemia, hypertensive disorder complicating pregnancy (PHD), and hydramnios of women with GDM were significant higher than those of women without GDM, and those of GDM women with poor glycemic control were also significant higher than those of GDM women with good glycemic control (P<0.05). There were no significant different in rates of premature rupture of membranes and postpartum hemorrhage between the women with GDM and the women without GDM (P>0.05). The incidences of fetus with large for gestalional age (LGA), fetal growth restriction (FGR), macrosomia, and hypoglycemia of neonates of women with GDM were significant higher than those of women without GDM, and those of GDM women with poor glycemic control were also significant higher than those of GDM women with good glycemic control (P<0.05). There were no significant different int the incidences of fetal distress and congenital malformation between the women with GDM and the women without GDM (P>0.05). Conclusion: The prevalence of GDM in Yili region of Xinjiang was at middle intermediate level of China and has population differences. It should be improved the level of perinatal healthcare of women from Yili region by targeted management measures for preventing GDM.

2019 Vol. 27　(12):　1656- [Abstract]（ 272 ） HTML (0 KB)  PDF  (0 KB)  ( 42 )

Objective: To compare the cinical effect of Yuangong medicine copper 220 and active γtype intrauterine device (IUD). Methods: From January 2017 to January 2018, 2138 healthy women of childbearing age who had inserted IUD were selected, wich included 1070 women in group A (women inserted Yuangong medicine copper 220 IUD) and 1068 women in group B (women inserted activeγtype IUD). The rates of pregnancy with IUD and termination related to expultion of IUD of all included women during 1 year after IUD inserted were observed. Results: The rate of pregnancy with IUD, the rate of termination related to expultion of IUD, and the removal rate caused by symptoms of women in group A were 0.47%, 0.56%, and 0.47%, which had no significant different from those (0.28%, 0.47%, and 0.37%) of women in group B (P>0.05). There were no significant different in the incidences of vaginitis, cervicitis, adnexitis and pelvic inflammation of women between the two groups (P>0.05). Conclusion: There are no significant different in the rate of pregnancy with IUD, the rate of termination related to expultion of IUD, and the removal rate caused by symptoms between Yuangong medicine copper 220 IUD and activeγtype IUD, so both IUDs have good clinical application value.

2019 Vol. 27　(12):　1664- [Abstract]（ 320 ） HTML (0 KB)  PDF  (0 KB)  ( 44 )

Objective: To analyze the relationship between the status of anxiety and depression of women undergone in vitro fertilization-embryo transfer (IVF-ET) and their serum monoamine neurotransmitters level and pregnancy outcomes. Methods: A total of 90 women who underwent IVF-ET were enrolled in the study from Jan. 2017 to Aug. 2018. The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used for investigating the status of anxiety and depression of included women when entering the cycle (T0), before egg retrieval (T1), and at 7d after embryo transfer (T2). The scores of SAS and SDS, and levels of serum Norepinephrine (NE), epinephrine (E), serotonin (5-HT) of women in different periods were compared between pregnancy women and non-pregnancy women. The relationship between pregnancy outcomes and the scores of SAS and SDS, and serum monoamine neurotransmitter level was analyzed. Results: There were significant differences in SAS scores and SDS scores among women undegoing IVF-ET at different stages (P<0.05). SAS and SDS scores at T1 were higher than those during T0 and T2 (P<0.05). After IVF-ET treatment, SAS and SDS scores during T1 of pregnant women were significant lower than those of nonpregnant women (P<0.05). After IVF-ET treatment, serum NE, E and 5-HT levels of pregnant women were higher than those of non-pregnant women during T1 (P<0.05). Spearman correlation analysis showed that SAS and SDS scores of women undergoing IVF-ET at T1 were negatively correlated with NE and 5-HT levels, and pregnancy rate (P<0.05). Conclusion: There is generally anxiety and depression disorders in women undergoing IVF-ET, which may be related to down-regulation of serum monoamine neurotransmitters levels, and affect pregnancy outcomes. Active measures should be taken to improve the psychological status of women undergone IVF-ET, and improve success rate of IVF-ET treatment.

2019 Vol. 27　(12):　1671- [Abstract]（ 341 ） HTML (0 KB)  PDF  (0 KB)  ( 42 )

Objective: To explore the effect of dynamic monitoring serumβ-hCG level of women after medical abortion for predicting abortion outcomes. Methods: The data of pregnant women within 49 gestational days who had experienced medical abortion were analyzed retrospectively. The serum β-hCG level of all included women were detected before abortion, and on the 10th and 20th day after abortion. And the change ofβ-hCG level were observed. Results: The serum β-hCG level of women with incompleted abortion before abortion, and on the 10th and 20th day after abortion were all significant higher than those of women with completed abortion (P<0.001). The descending rate of serum β-hCG level of women with completed abortion on the 10th day and 20th were 94.0±12.0% and 99.6±12.6%, which were all significant higher than those(61.1±8.6% and 94.1±12.1%) of women with uncompleted abortion（P=0.001, 0.005）. ROC working curve analysis showed that when the decrease rate of serumβ-hCG level was over 93.49% on the 10th day after abortion, and that was over 97.87% on the 20th day after abortion, the abortion prognosis could be better. Conclusion: The decrease rate of serumβ-hCG level of women should be dynamically monitored after medical abortion, which is expected to provide a reference for further surgical intervention.

2019 Vol. 27　(12):　1679- [Abstract]（ 277 ） HTML (0 KB)  PDF  (0 KB)  ( 41 )

Objective: To explore the relationship between levels of serum angiopoietin-like protein 4 (ANGPTL4) and angiopoietin-like protein 6 (ANGPTL6) and insulin resistance of pregnant women with gestational diabetes mellitus (GDM). Methods: 58 pregnant women with GDM were selected in study group from May 2017 to May 2018, and 60 healthy pregnant women were in control group. The information of women in the two groups were collected, and the the relationship between serum ANGPTL4 and ANGPTL6 levels and insulin resistance index (HOMA-IR) and the risk factors affecting insulin resistance were analyzed. Results: The levels of triglyceride (TG), VEGF, glycated hemoglobin (HbAlc), fasting blood glucose (FPG), fasting insulin (FINS), and HOMA-IR of women in the study group were significant higher than those of women in the control group, but the levels of ANGPTL4 and ANGPTL6 of women in the study group were significant lower (P<0.05). Pearson correlation analysis showed that serum ANGPTL4 and ANGPTL6 levels were negatively correlated with HOMA-IRI (r = 0.653, 0.777, P = 0.001, 0.000). Multiple linear regression analysis showed that ANGPTL4 level was a risk factor of insulin resistance. Conclusion: Serum ANGPTL4 and ANGPTL6 levels of pregnant women with GDM have significantly decreased, which are closely related to their glucose tolerance and insulin resistance.

2019 Vol. 27　(12):　1686- [Abstract]（ 326 ） HTML (0 KB)  PDF  (0 KB)  ( 34 )

Objective: To explore the expression of placental growth factor (PIGF) of pregnant women with early-onset severe preeclampsia (SPE), and to study its relationship with pregnancy outcomes. Methods: 80 pregnant women with early-onset SPE were enrolled in observation group and 100 normal pregnant women were in control group from January 2017 to December 2018. On the delivery day, the plasma PIGF level of women in both groups was detected, and clinically relevant indexes of women in both groups were observed. The relationship between PIGF level of women in observation group and their pregnancy outcomes was analyzed. Results: The plasma PIGF level of women in the observation group were significant lower than that of women in the control group, but the values of SBP, DBP and S/D of women in the observation group were significant higher (P<0.05).The abnormal rate of plasma PIGF level of women in the observation group was 51.3%. The neonatal gestational weeks of birth, birth weight, placental weight, and 1 min Apgar score of pregnant women with abnormal PIGF level were significant lower than those of pregnant women with normal PIGF level (P<0.05), while values of LAC and umbilical artery S/D of pregnant women with abnormal PIGF level were significant higher (P<0.05). Correlation analysis showed that the expression level of PIGF of pregnant women with early-onset SPE were negatively correlated with the values of SBP, DBP and umbilical artery S/D, while were positively correlated with neonatal birth weight and 1 min Apgar score (P<0.05). Conclusion: The expression level of PIGF of pregnant woman with earlyonset SPE is closely related to pregnancy outcomes. The PIGF level of pregnant women has some clinical value for predicting pregnancy outcomes, so it should be more focused on.

2019 Vol. 27　(12):　1693- [Abstract]（ 303 ） HTML (0 KB)  PDF  (0 KB)  ( 43 )

Objective: To investigate the relationship between iron deficiency of pregnant women during the first trimester pregnancy and the pregnancy and birth outcomes. Methods: 1982 pregnant women during the first trimester pregnancy were selected in this study from December 2015 to December 2018.  The levels of serum ferritin, soluble transferrin receptor (sTfR) of all women were measured, and their total body iron (TBI) was calculated based on sTfR and serum ferritin. The levels of serum ferritin, sTfR and TBI were used to evaluate iron status of pregnant women. The influence of iron deficiency (ID) based on different diagnostic criteria during the first trimester pregnancy on pregnancy and birth outcomes of women were explored. Results: Among the 1982 pregnant women, 390 (19.7%) women with serum ferritin<20μg/L, 301(15.2%) women with sTfR>21 nmol/L. and 319(16.1%) women with TBI<0mg/kg. The ID (defined as serum ferritin<20μg/L) was negatively associated with the risk of gestational diabetes mellitus (GDM) (HR 0.47, 95%CI 0.38-0.73), and that was positively associated with the risk of large for gestational age (LGA) (HR 1.32, 95%CI 1.07-1.66). The ID (defined as sTfR>21nmol/L) was positively associated with the risk of pregnancyinduced hypertension (HR 1.31, 95%CI 1.17-1.52). And the ID (defined by TBI<0mg/kg) was negatively associated with the risk of GDM (HR 0.36, 95%CI 0.17-0.72), but that was positively associated with the risk of LGA (HR 1.37, 95%CI 1.04-1.92). Conclusion: ID during the first trimester pregnancy is negatively associated with the risk of GDM and is positively associated with the risk of LGA and pregnancy-induced hypertension.

2019 Vol. 27　(12):　1704- [Abstract]（ 326 ） HTML (0 KB)  PDF  (0 KB)  ( 34 )

In recent years, there have been significant advances in controlled release dosage forms used for contraception, which has provided more contraceptive options for women. Currently, the widely used controlled release contraceptives include vaginal rings, subcutaneous implants, intrauterine devices and so on, but these products have not fully met the contraceptive needs of women. Therefore, it is necessary to develop new controlled release contraceptives with better compliance, higher safety and better efficacy to improve the living quality of women.

2019 Vol. 27　(12):　1717- [Abstract]（ 344 ） HTML (0 KB)  PDF  (0 KB)  ( 43 )