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| Contraceptive effect of levonorgestrel IUD, and its influence on IL-6, IL-10 and TNF-α |
| Bazhong Central Hospital, Sichuan Province, 636000 |
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Abstract Objective: To investigate the contraceptive effect of levonorgestrel intrauterine device(IUD), and its influence on serum interleukin-6(IL-6), interleukin-10 (IL-10) and tumor necrosis factor TNF-α. Methods: 200 women were selected and were divided randomly into study group (100 women inserted levonorgestrel IUD) and control group (100 women inserted TCu380A IUD) by random number table from January 2017 to January 2018. The rates of contraceptive effect and adverse reaction, and serum IL-6, IL-10, TNF-α levels of women in 1 year after IUD inserted in both groups were observed. Results: The termination rate of IUD use-related of women in the study group was 1.0%, which had no significant different from that (3.0%) of women in the control group(P>0.05). The rate of menorrhagia and lumbar and abdominal pain of women in the study group were 1.0% and 6.0%, which were significant lower than those (20.0% and 24.0%) of women in the control group(P<0.05). The rate of reduction in menstrual blood loss of women in the study group was 27.0%, which was significant higher than that (2.0%) of women in the control group(P<0.05). Before IUD inserted, there were no significant different in the levels of IL-6, IL-10, TNF-α of women in both groups, but the levels of IL-6, IL-10, TNF-α of women in the study group were significant lower than those of women in the control group(P<0.05). Conclusion: The contraceptive effect of levonorgestrel IUD is equivalent to that of TCu380A IUD, but the inflammatory reaction and adverse reactions caused by levonorgestrel IUD are lower.
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