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| Effect of antibiotics used in different treatment regimens after hysteromyomectomy and its influence on serum inflammatory factors |
| 1. The Second Hospital Affiliated to Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi Province, 712000; 2. Affiliated Hospital of Yan'an University |
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Abstract Objective: To investigate the influence of antibiotics used in different courses of treatment and timing of administration on the levels of blood inflammatory factors and adverse reactions of women with uterine fibroids. Methods: The clinical data of 120 women with uterine fibroids who had experienced hysteromyomectomy from June 30, 2018 to March 30, 2019 were collected. According to the timing and course of antibiotics used, the included women were divided into 4 groups (30 cases in each group). The women in group A were given intravenous antibiotics 1h before operation, the women in group B were given intravenous antibiotics 1h before operation and 6h after operation, the women in group C were given intravenous antibiotics 1h before operation and 3d after operation (2 times/d), and the women in group D were given intravenous antibiotics after 3 days (2 times/d). Results: The postoperative hospital stay, hospitalization expenses, the body temperature, blood cell level at 24 and 48 hours after operation, and the levels of CRP, TNF-α, IFN-γ and IL-6 of women in group D were highest (P<0.05). There was no significant different in rates of grade A healing and grade B healing of women between the groups (P>0.05). The incidence of total infection of women in group D and group A was significant higher than that of women in group B and C (P<0.05). The incidence of total adverse reaction of women in group C and D was significant higher than that of women in group A and group B (P<0.05). Conclusion: The antibacterial therapy in short course for treating women before and after hysteromyomectomy has the best effect and safety.
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