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| Value of serum miR-501 and miR-195b levels for diagnosising and predicting prognosis of cervical cancer |
| The First People's Hospital of Yancheng, Yancheng, Jiangsu Province, 224002 |
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Abstract Objective: To investigate the expression levels of serum miR-501 and miR-195 of women with cervical cancer, and to study their clinical significance. Methods: The data of 61 women with cervical cancer (in study group) and 35 healthy women (in control group) were retrospective analyzed. The levels of serum miR501 and miR-195 of women in both groups were detected, and the relationships between the expression levels of miR-501 and miR-195 and the clinicopathological characteristics and survival time of women were analyzed. Results: Compared to that of healthy women, the expression level of serum miR-501 of women with cervical cancer had up-regulated and the expression level of miR-195 had down-regulated (P<0.05). The expression levels of serum miR-501 and miR-195 of women were no related to the age, HPV infection, degree of tumor differentiation (P>0.05), but those were associated with clinical TNM staging and lymph node metastasis of cervical cancer (P<0.05). The women with higher level expression of serum miR-501 and lower expression level of miR-195 could be live longer. Conclusion: The expression level of serum miR-501 of women with cervical cancer has increase and the expression level of miR-195 has decreased, which can be used as the markers for diagnosing and evaluating the prognosis of cervical cancer.
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