Abstract Objective: To explore the value of serum N-terminal B-type natriuretic peptide (NT-proBNP) combined with Tei index for evaluating the left ventricular function of pregnant women with pregnancy-induced hypertension. Methods: 61 pregnant women with pregnancy-induced hypertension were selected in study group and 50 normal pregnant women were selected in control group. All included women were checked by echocardiography and their serum NT-proBNP level was detected. The women in the observation group were further divided into study group 1 (26 women with pregnancy-induced hypertension), study group 2(25 women with mild preeclampsia) and study group 3 (10 women with severe preeclampsia) according to the condition of pregnancy-induced hypertension. The values of Left ventricular end-diastolic diameter (LVIDd), left ventricular end-systolic diameter (LVIDs), right atrial diameter (RVDd), and left ventricular ejection fraction (LVEF), and Tei index value and serum NT-proBNP level of women were compared among the four groups. Pearson correlation analysis was used for evaluating the correlation of the serum NT-ProBNP level and Tei index value with the values of LVIDd, LVIDs, RVDd and LVEF. Results: The values of LVIDs, Tei index, and serum NTProBNP level of women in the study group were 30.28±5.6 2mm, 0.39±0.13, and 142.02±12.35 pg/ml,respectively, which were significant higher than those (26.35±3.51 mm, 0.21±0.05,86.25±6.97 pg/ml, respectively) of women in the control group, but LVEF value of women in the study group was 64.25±5.69%, which was significant lower than that(68.25±6.85%) of women in the control group (P<0.05).In the study group, the Tei index value and serum NT-ProBNP level had increased with the situation of pregnancy-induced hypertension became severity (P<0.05), but LVEF value had decreased (P<0.05). Pearson correlation analysis showed that serum NT-ProBNP level and Tei index value were positively correlated with LVIDd value (r=0.265, 0.273, P<0.05), and negatively correlated with LVEF (r=-0.625, -0.521, P<0.05). Conclusion: Serum NT-ProBNP level and Tei index value of women with pregnancy-induced hypertension have increased significantly, which are negatively correlated with left ventricular systolic function of pregnant women, so it maybe as an effective index for clinical monitoring left ventricular function.
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