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| Relationship between iron deficiency during the first trimester pregnancy and the pregnancy and birth outcomes |
| Traditional Chinese Medicine Hospital of Shuyang County, Jiangsu Province, 223600 |
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Abstract Objective: To investigate the relationship between iron deficiency of pregnant women during the first trimester pregnancy and the pregnancy and birth outcomes. Methods: 1982 pregnant women during the first trimester pregnancy were selected in this study from December 2015 to December 2018. The levels of serum ferritin, soluble transferrin receptor (sTfR) of all women were measured, and their total body iron (TBI) was calculated based on sTfR and serum ferritin. The levels of serum ferritin, sTfR and TBI were used to evaluate iron status of pregnant women. The influence of iron deficiency (ID) based on different diagnostic criteria during the first trimester pregnancy on pregnancy and birth outcomes of women were explored. Results: Among the 1982 pregnant women, 390 (19.7%) women with serum ferritin<20μg/L, 301(15.2%) women with sTfR>21 nmol/L. and 319(16.1%) women with TBI<0mg/kg. The ID (defined as serum ferritin<20μg/L) was negatively associated with the risk of gestational diabetes mellitus (GDM) (HR 0.47, 95%CI 0.38-0.73), and that was positively associated with the risk of large for gestational age (LGA) (HR 1.32, 95%CI 1.07-1.66). The ID (defined as sTfR>21nmol/L) was positively associated with the risk of pregnancyinduced hypertension (HR 1.31, 95%CI 1.17-1.52). And the ID (defined by TBI<0mg/kg) was negatively associated with the risk of GDM (HR 0.36, 95%CI 0.17-0.72), but that was positively associated with the risk of LGA (HR 1.37, 95%CI 1.04-1.92). Conclusion: ID during the first trimester pregnancy is negatively associated with the risk of GDM and is positively associated with the risk of LGA and pregnancy-induced hypertension.
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