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| Relationship between the coagulation function, and serum levels of homocysteine and B vitamins of pregnant women and their occurrence of early threatened abortion |
| Shunyi Maternal and Children Health Care Hospital, Shunyi Maternal and Children Hospital of Beijing Children Hospital, Beijing, 101300 |
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Abstract Objective: To investigate the relationship between the coagulation function, and serum levels of and B vitamins of pregnant women and their occurrence of early threatened abortion. Methods: 299 pregnant women with threatened abortion were collected and included into study group from 2015 November to 2016 December，and 290 health pregnant women were selected into control group during the same period. According to the pregnancy outcomes，the women in the study group were divided into group A (186 women with smooth delivery)，group B (79 women with inevitable abortion), and group C (34 women with missed abortion). The levels of coagulation function index (PLT, Fbg and D-dimer), serum homocysteine (Hcy)，B vitamins (folic acid and Vitamin B12) of women were compared between the two groups. Results: The levels of PLT, Fbg, D-dimer and Hcy of women in study group were （246±41）×109/L, 4.37±0.49g/L, 0.75±0.24mg/L, and 10.48±2.94μmol/L, respectively, which were significantly higher than those (211±43）×109/L, 3.52±0.28g/L, 0.39±0.06mg/L, and 6.75±2.43μmol/L of women in the control group(P＜0.01). The levels of folic acid and Vitamin B12 of women in study group were 10.31±1.75nmol/L and 206.81±
93.45pmol/L, which were significantly higher than those (20.36±2.08nmol/L and 301.98±176.12pmol/L) of women in the control group(P＜0.01). The Hcy level of women in group A, B, and C were 6.62±2.18μmol/L, 10.57±2.44μmol/L , and13.41±2.85μmol/L, and the Hcy level of women in group A was significant lower than that of women in group C (P<0.05). The PLT level of women in group A, B, and C were （236±42）×109/L, （245±58）×109/L and （259±54）×109/L, and the PLT level of women in group A was the lowest and that women in group C was the highest (P<0.05). The Fbg level of women in group A, B, and C were 3.51±0.27g/L, 4.19±0.32g/L, and 4.86±0.43g/L, and the Fbg level of women in group A was the lowest and that women in group C was the highest (P<0.05). The D-dimer level of women in group A, B, and C were 0.69±0.04mg/L, 0.78±0.1mg/L and 0.86±0.08mg/L, and the D-dimer level of women in group A was the lowest and that women in group C was the highest (P<0.05). The folic acid level of women in group A, B, and C were 38.56±2.84nmol/L, 22.78±1.91 and 10.43±0.25nmol/L, and the folic acid level of women in group A was the highest and that women in group C was the lowest (P<0.05). The Vitamin B12 level of women in group A, B, and C were 237.76±59.01pmol/L, 159.89±46.54 pmol/L and 115.41±32.78pmol/L, and the folic acid level of women in group A was significant higher than that of women in group C (P<0.05). Conclusion: Detection of the levels of serum PLT，Fbg，D-dimers，Hcy, folic acid and vitamin B12 is expected to be the index for predicting threatened abortion of pregnant women, which also help for predicting pregnancy outcomes.
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