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Abstract Objective: To analyze the influence of dexamethasone combined with pituitrin for treating women with postpartum hemorrhage on the levels of RhoA and Rho associated coiled coil forming protein kinase(ROCK). Methods: 88 high risk pregnant women were selected as the research objects, and they were divided into control group(n=46) and research group(n=42) from June 2017 to December 2018 according to simple random method. The women in the control group were treated by dexamethasone, and the women in the research group were treated by dexamethasone combined with pituitrin. The hemostatic efficacy, postpartum bleeding volume, levels of RhoA, ROCK Ⅰ,and ROCK Ⅱ protein, blood pressure value, and heart rate before and after treatment, and adverse reactions rate of women were compared between groups. Results: The total effective rate and level of hemoglobin of women in the research group were 97.6% and 121.1±16.0g/L, which were signifficent higher than those (84.8% and 113.1±13.3g/L) of women in the control group (P<0.05). Volume of 2h and 24h postpartum blood loss, and postpartum bleeding rate of women in the research group were 172.0±23.2ml, 255.1±31.2ml, and 2.4%, which were signifficent lower than those (287.3±38.7ml, 340.2±45.3ml, and 15.2%) of women in the control group (P<0.05). The protein levels of RhoA, ROCK Ⅰ, and ROCK Ⅱ of women in the research group were 0.59±0.07 ng/ml, 0.40±0.06 ng/ml, and 0.38±0.05 ng/ml, which were signifficent higher than those of women in the control group (P<0.05). There were no significant different in the values of diastolic and systolic blood pressure, heart rate, and adverse reactions rate of women between the two groups (P>0.05). Conclusion: Dexamethasone combined with pituitrin can enhance uterine contraction, regulate RhoA and ROCK protein expression, prevent postpartum hemorrhage caused by uterine contraction, and has good safty.
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