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Abstract Objective: To explore influence of continuous positive airway through the nose for treating pregnant women with obstructive sleep apnea hypopnea syndrome (OSAHS) serum advanced oxidative protein products (AOPP), macrophage migration inhibitor (MIF), and interleukin 18 (Il-18). Methods: 70 pregnant women with OSAHS were selected and were divided into observation group (n=40) and the control group (n=30) by random number table from September 2015 to September 2017. The women in the observation group were given nasal continuous positive airway pressure, and the women in the control group were given oral orthotics. The clinical curative effect, serum AOPP, MIF, and IL-18 levels, the rate of apnea at night, apnea hypoventilation index (AHI), blood oxygen saturation, blood pressure and life quality before and after the treatment of women were compared between the two groups. Results: After treatment, the effective rate of women in the observation group was 92.5%, which was significant higher than that(73.3%) of women in the control group (P<0.05). The levels of serum AOPP, MIF and Il-18 of women in the two groups had decreased significantly after treatment, and the levels of serum AOPP, MIF and Il-18 of women in the observation group were significant lower than those of women in the control group (P<0.05). The AHI, minimum oxygen saturation, and maximum apnea time of women in both groups had improved significantly after treatment, and AHI and maximum apnea time of women in the observation group were significant lower than those of women in the control group, but lowest oxygen saturation of women in the observation group was significant higher (P<0.05). The values of systolic blood pressure, diastolic blood pressure, and mean arterial pressure of women in the observation group were significant lower than those of women in the control group (P<0.05) after treatment. After treatment, the quality of life scores of women in the two groups were significantly increased, and that of women in the observation group was significant higher than that of women in the control group (P<0.05). Conclusion: The continuous positive airway through the nose for treating pregnant women with OSAHS can achieve ideal clinical efficacy, which can alleviate the clinical symptoms and improve the quality of life of pregnant women.
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