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| The status of anxiety and depression of women undergone IVF-ET and its relationship with their serum monoamine neurotransmitters level and pregnancy outcomes |
| 1.Hainan Anning Hospital, Hainan Province, 570100; 2.Hefei Zhongshan Hospital Anhui province |
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Abstract Objective: To analyze the relationship between the status of anxiety and depression of women undergone in vitro fertilization-embryo transfer (IVF-ET) and their serum monoamine neurotransmitters level and pregnancy outcomes. Methods: A total of 90 women who underwent IVF-ET were enrolled in the study from Jan. 2017 to Aug. 2018. The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used for investigating the status of anxiety and depression of included women when entering the cycle (T0), before egg retrieval (T1), and at 7d after embryo transfer (T2). The scores of SAS and SDS, and levels of serum Norepinephrine (NE), epinephrine (E), serotonin (5-HT) of women in different periods were compared between pregnancy women and non-pregnancy women. The relationship between pregnancy outcomes and the scores of SAS and SDS, and serum monoamine neurotransmitter level was analyzed. Results: There were significant differences in SAS scores and SDS scores among women undegoing IVF-ET at different stages (P<0.05). SAS and SDS scores at T1 were higher than those during T0 and T2 (P<0.05). After IVF-ET treatment, SAS and SDS scores during T1 of pregnant women were significant lower than those of nonpregnant women (P<0.05). After IVF-ET treatment, serum NE, E and 5-HT levels of pregnant women were higher than those of non-pregnant women during T1 (P<0.05). Spearman correlation analysis showed that SAS and SDS scores of women undergoing IVF-ET at T1 were negatively correlated with NE and 5-HT levels, and pregnancy rate (P<0.05). Conclusion: There is generally anxiety and depression disorders in women undergoing IVF-ET, which may be related to down-regulation of serum monoamine neurotransmitters levels, and affect pregnancy outcomes. Active measures should be taken to improve the psychological status of women undergone IVF-ET, and improve success rate of IVF-ET treatment.
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