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| Study of the relationship between serum ANGPTL4 and ANGPTL6 levels and insulin resistance of women with gestational diabetes mellitus |
| Yan 'an Hospital Affiliated to Kunming Medical University, kunming,Yunnan Province, 650000 |
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Abstract Objective: To explore the relationship between levels of serum angiopoietin-like protein 4 (ANGPTL4) and angiopoietin-like protein 6 (ANGPTL6) and insulin resistance of pregnant women with gestational diabetes mellitus (GDM). Methods: 58 pregnant women with GDM were selected in study group from May 2017 to May 2018, and 60 healthy pregnant women were in control group. The information of women in the two groups were collected, and the the relationship between serum ANGPTL4 and ANGPTL6 levels and insulin resistance index (HOMA-IR) and the risk factors affecting insulin resistance were analyzed. Results: The levels of triglyceride (TG), VEGF, glycated hemoglobin (HbAlc), fasting blood glucose (FPG), fasting insulin (FINS), and HOMA-IR of women in the study group were significant higher than those of women in the control group, but the levels of ANGPTL4 and ANGPTL6 of women in the study group were significant lower (P<0.05). Pearson correlation analysis showed that serum ANGPTL4 and ANGPTL6 levels were negatively correlated with HOMA-IRI (r = 0.653, 0.777, P = 0.001, 0.000). Multiple linear regression analysis showed that ANGPTL4 level was a risk factor of insulin resistance. Conclusion: Serum ANGPTL4 and ANGPTL6 levels of pregnant women with GDM have significantly decreased, which are closely related to their glucose tolerance and insulin resistance.
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