To observe the expression of long non-coding RNA (lncRNA) nucleolar small RNA host gene 5 (SNHG5) in ovarian cancer tissues, and to analyze the effect of SNHG5 expression on autophagy of ovarian cancer cells. Methods: 73 women with ovarian cancer were selected in group A and 82 women with ovarian cyst were selected in group B from August 2018 to March 2019. The expression of SNHG5 in ovarian tissues of women in the two groups was detected by real-time fluorescence quantitative PCR (qRT-PCR), and the relationships between the expression of SNHG5 in ovarian cancer tissue and clinical pathology of women in group A was analyzed. SKOV3 cells were cultured as blank control group, and SKOV3 cells transfected with empty plasmid pcDNA3.1 (+) and recombinant plasmid pcDNA3.1-SNHG5 by Lipofectamine 2000 reagent were in negative control group and SNHG5 over expression group respectively. Cell counting kit (CCK8) method was used to detect the proliferation of SKOV3 cells in each group, the autophagy level of SKOV3 cells in each group was detected by fluoroscopy and electron microscopy, and the expression levels of LC3-I, LC3-II and Beclin 1 protein were detected by immunoblotting (WB). Results: Compared with that (1.13±0.23) in group B, the relative expression (0.49±0.06) of LNC RNA-SNHG5 in group A was significant lower (P<0.05). Compared with that in histological grade G1-G2 and FIGO stage I-II, the percentage of patients with high expression of LNC RNA-SNHG5 in histological grade G3 and FIGO stage III-IV was significant higher (P<0.05). Compared with that (1.03±0.20) in blank control group and that (1.05±0.21) in negative control group, the relative expression of SNHG5 in SNHG5 over expression group (1.97±0.37) had increased significantly (P<0.05). The inhibition rates of SKOV3 cell proliferation in SNHG5 over expression group at 48h, 72h and 96h after transfection were 23.64±4.73%, 43.57±8.71%, and 57.82±11.56%, respectively, which were significant higher than those in blank and negative control group (P< 0.05). Compared with those in the blank group or the negative control group, the proportion of MDC positive cells in SNHG5 over expression group (42.38±7.64) was significant higher, the expression of LC3-I protein in SNHG5 over expression group (0.16±0.03) was significant lower, and the expression of LC3-II or Beclin 1 proteins  (0.86±0.18 or 0.97±0.18) was significant higher (all P<0.05). Conclusion: The expression of lncRNA-SNHG5 in ovarian cancer tissues is low and the over expression of lncRNA-SNHG5 significantly inhibits the viability of human ovarian cancer cells and promotes autophagy of cells.

2020 Vol. 28　(11):　1731-1735 [Abstract]（ 471 ） HTML (0 KB)  PDF  (0 KB)  ( 41 )

2020 Vol. 28　(11):　1742-1747 [Abstract]（ 327 ） HTML (0 KB)  PDF  (0 KB)  ( 36 )

To understand the status quo of the monitoring site of adverse reactions of contraception in a western province, and to put forward the targeted improvement measures, so as to provide scientific evidence for improving the monitoring level of adverse reactions of contraception. Method: Field surveys through interviews, questionnaires, and verification of medical document were conducted on contraceptives adverse reactions surveillance site. Results: This survey involved more than 60 relevant leaders and technical backbones from provinces, cities, counties/districts, and towns/sub-districts of 11 government departments. The monitoring site focuses on strengthening follow-up services and medical information file management. Deficiencies in monitoring reports were found such as the decrease in quantity, underreporting, timeliness lag, incompleteness, irregularity, misreporting, and correlation analysis errors. Conclusion: It is necessary to improve the working mechanism, to establish a scientific assessment and quality control system, and to strengthen the training and propaganda for contraceptives adverse reactions surveillance.

2020 Vol. 28　(11):　1752-1755 [Abstract]（ 472 ） HTML (0 KB)  PDF  (0 KB)  ( 32 )

To observe the clinical efficacy of "Zhuyu Suogong Granules" on Qi deficiency and blood stasis syndrome caused by medical abortion in 8-12 weeks of pregnancy. Method: 98 cases were randomly divided into observation group (49 cases) and control group (49 cases). Both groups were routinely given oxytocin after the fetal sac and buds were discharged. The observation group was given "Zhuyu Suogong Granules" for 7 consecutive days; the control group was not treated with other drugs. The bleeding volume, bleeding time, Uterine cleaning surgery rate, pelvic infection rate and menstrual recovery time were observed in the two groups. Result: The bleeding volume and bleeding time of the observation group were less than those of the control group (P<0.05); the Uterine cleaning surgery rate was 8.2% in the observation group and 24.5% in the control group (P<0.05); the pelvic infection rate was 2.0% in the observation group and 12.2% in the control group （P＜0.05); The menstrual recovery time was (30.2±3.3) days in the observation group and (38.7±6.1 days) in the control group (P＜0.05); there were no obvious adverse reactions in both groups. Conclusion：After medical abortion in 8 to 12 weeks of pregnancy, oral administration of "Zhuyu Suogong Granules" can reduce the amount of bleeding, shorten the bleeding time, reduce the rate of uterine curettage and pelvic infection, and shorten the time of menstrual.

2020 Vol. 28　(11):　1761-1763 [Abstract]（ 335 ） HTML (0 KB)  PDF  (0 KB)  ( 36 )

To observe the effect of oil-free condom on sperm fertilization function and the detection results of DNA fragment index (DFI) of sperm. Methods: 1.0ml liquefied semen was puted in the oil-free condom in the experimental group, which was placed in an oscillator and gently oscillated for 5min before being removed, and then was transferred to a 5ml centrifugation tube. 1.0ml liquefied semen was not in oil-free condom in the control group. Sperm motility in both groups was detected 15 min later, and then sperm acrosin activity, acrosomal reaction rate and DFI were immediately detected. The semen was compared between the experimental group and the control group. Results: The sperm motility of the experimental group was 58.7±12.4 % was significant lower than that (63.6±11.4 %) of the control group (P＜0.05). The activity of sperm acrosin of the experimental group was 102.0±26.3 U/106 sperm was significant higher than that (84.6±23.0 U/106 sperm ) of the control group  (P＜0.05). The acrosomal reaction rate of the experimental group was 40.7±14.8 % was significant lower than that (48.4±15.8%) of the control group (P＜0.01). There was no significant difference in DFI between the two groups (P＞0.05). Conclusion: It is not recommended to use oilfree condoms to collect samples for the detection of sperm motility, sperm acrosin activity and sperm acrosome reaction.

2020 Vol. 28　(11):　1768-1770 [Abstract]（ 321 ） HTML (0 KB)  PDF  (0 KB)  ( 36 )

To compare the efficacy of letrozole combined with clomiphene and clomiphene alone for treating women with difficult ovulatory. Methods: 146 women with ovulatory disorder were selected and divided into two groups from July 2018 to July 2019. The women in control group were treated with clomiphene alone, and the women in observation group were treated with letrozole combined with clomiphene. The clinical efficacy of women in the two groups after treatment was analyzed. Results: The endometrium thickness (9.86 ± 1.28) mm, uterine volume (5.58±0.96) ml, mature follicle diameter (25.98 ± 2.85) mm of women in the observation group were significant higher than those of women in the control group, but diestradiol (E2) level on hCG day of women in the observation group (428.12 ± 76.25 pg/ml) was significant lower than that of women in the control group (P<0.05). The levels of luteinizing hormone (LH) and testosterone(T) of women in the observation group were  10.18 ± 3.66 IU/ml and 58.01 ± 12.79 ng/dl, which had no significant different from those of women in the control group (P>0.05). The levels of connective tissue growth factor (CTGF) and tumor necrosis factor-α (TNF-α) of women in the observation group were significant lower than those of women in the control group (P<0.05), but there were no significant different in the level of serum insulinlike growth factor (IGF-1) between the two groups (P>0.05). The ovulation rate (68.5%) and pregnancy rate (49.3%) of women in the observation group were significant lower than those of women in the control group (P<0.05), but the abortion rate (2.7%) of women in the observation group had no significant different from those of women in the control group (P>0.05). Conclusion: The effect of letrozole combined with cromiprofen for treating difficult ovulation of women with PCOS is better than that of cromiprofen used alone.

2020 Vol. 28　(11):　1774-1777 [Abstract]（ 295 ） HTML (0 KB)  PDF  (0 KB)  ( 35 )

2020 Vol. 28　(11):　1782-1785 [Abstract]（ 406 ） HTML (0 KB)  PDF  (0 KB)  ( 32 )

To investigate the effect of desogestrel and ethinylestradiol tablets on endometrial repair of women with medical abortion after uterine curettage. Methods: 100 women with medical abortion after uterine curettage were randomly divided into two groups (50 cases in each group). The women in observation group were given oral deoxypregnene ethinylestradiol tablets, while the women in control group were not given treatment. Vaginal bleeding volume, uterine involution situation, and complications rate of women were compared between the two groups. Results: Two weeks after abortion, the endometrial thickness (3.20±0.74mm) of women in the observation group was significant higher than that (2.71±0.17mm) of women in the control group, but the uterine transverse diameter and longitudinal diameter of women in the observation group were significant lower (P<0.05). The time of vaginal bleeding after operation of women in both groups was less than 10 days, but the proportion of women with vaginal bleeding time ≤5 days in the observation group (86.0%) was significant higher than that (50.0%) of women in the control group, the proportion of women with vaginal bleeding volume less than menstruation in the observation group (80.0%) was significant higher than that (60.0%) of women in the control group, the proportion of women with the time of menstruation recovery ＜30d in the observation group (92.0%) was significant higher than that (72.0%) of women in the control group, and the total incidence of postoperative complications of women in the observation group (4.0%) was significant lower than that (26.0%) of women in the control group (all P<0.05). Conclusion: Oral deoxypregnene ethinylestradiol tablets after uterine curettage can promote endometrial repair, shorten the time of vaginal bleeding, regulate menstrual cycle, and reduce the risk of uterine adhesions.

2020 Vol. 28　(11):　1790-1792 [Abstract]（ 367 ） HTML (0 KB)  PDF  (0 KB)  ( 37 )

2020 Vol. 28　(11):　1798-1802 [Abstract]（ 308 ） HTML (0 KB)  PDF  (0 KB)  ( 35 )

To analyze vitamin A and E levels of pregnant women with preeclampsia and their perinatal complications. Methods: From 45,305 women with preeclampsia from June 2016 to May 2019, 200 cases were randomly selected in study group, and 200 healthy pregnant women were selected in control group during the same period. The vitamin A and E levels of women were compared between the two groups. The women in the study group were divided in two groups (100 cases in each group) by random number table, the women in group A were given vitamin A and vitamin E for two weeks, and the women in group B were given placebo for two weeks. The levels of vitamin A and vitamin E after treatment, blood lipid index, and perinatal complications of women, and neonatal outcomes were compared between group A and B. Results: The levels of vitamin A and E of women in the study group were significant lower than those of women in the control group (P<0.05). After 2 weeks of treatment, the levels of vitamin A (19.62±3.62) and E (43.52±4.88) of women in group A were significant higher than those of women in group B (P<0.05). 4 weeks after treatment, the levels of low-density lipoprotein cholesterol, triglyceride, and total cholesterol of women in group A were significant lower than those of women in group B, but the level of high-density lipoprotein cholesterol of women in group A was higher (P<0.05). The incidences of postpartum hemorrhage (1.0%), premature rupture of membranes (0.0%), fetal growth restriction (0.0%), oligohydramnios (1.0%), neonatal asphyxia (0.0%), fetal distress (1.0%), and low birth weight (0.0%) of women in group A were significant lower than those (7.0%, 4.0%, 5.0%, 7.0%, 4.0%, 7.0%, and 4.0%,respectively) of women in group B (P<0.05). Conclusion: Vitamin A and E levels are negatively correlated with preeclampsia. The vitamins A and E supplementation timely of pregnant women with preeclampsia can effectively reduce their perinatal complications rates, and can significantly improve the levels of lipid indicators.

2020 Vol. 28　(11):　1807-1810 [Abstract]（ 337 ） HTML (0 KB)  PDF  (0 KB)  ( 33 )

To explore the effect of dexmedetomidine combined with ropivacaine for labor analgesia by maternal self-controlled epidural given drugs. Methods: 90 pregnant women with full-term pregnancy were selected and were randomly divided into 3 groups (30 cases in each group) according to the graded Ⅰ to Ⅱ by the American Society of Anesthesia (SAS) from January 2019 to June 2019. All women were given epidural self-controlled analgesia during delivery, and the women in group A were given anesthesia with 0.12% ropivacaine, the women in group B were given 0.12% ropivacaine combined with 2 μg / ml fentanyl, and the women in group C were given 0.12% ropivacaine combined with 2 μg / ml dexmedetomidine. The heart rate (HR),  mean arterial pressure of the fetus (MAP), and visual analogue scale (VAS) scores of the women in the three groups before maternal analgesia delivery (T0), 10min after analgesia (T1), 30min after analgesia (T2), at the full opening of the uterine cavity (T3), and immediately after delivery (T4) were recorded. The modified Bromage score and Ramsay sedation score of the women in the three groups at 30 minutes after maternal analgesia were recorded. The number of maternal analgesia pump compressions, duration of labor, 2h postpartum hemorrhage amount, newborn Apgar score, and maternal satisfaction score of the women in the three groups were recorded. The onset of lactation, and the serum prolactin (PRL) level before analgesia delivery analgesia, immediately after delivery, and 2h after delivery of women in the three groups were monitored. The rate of adverse reactions of the women in the three groups was also recorded. Results: The values of HR and MAP of women in the three groups at T1-T3 were significant lower than those of women at T0 (P<0.05), but there were no significant difference in the values of HR and MAP among the three groups (P>0.05). VAS score of women in the three groups at T1-T4 was significant lower than that of women at T0 (P<0.05), and that of women in group A was the highest (P<0.05). The modified Bromage scores of women in the three groups 30 minutes after analgesia were grade 0, and which of women in group C was the highest, and the number of analgesia pump compressions of women in group C was the lowest (all P<0.05). There were no significant difference in the time of the first and the second labor, the bleeding amount in postpartum 2h, and the Apgar score of newborns among the three groups (P>0.05). The maternal satisfaction scores in group B and C were significant higher than that of women in group A (P<0.05). The serum prolactin (PRL) level immediately after delivery and 2h after delivery of women in group C was significant higher than that of women in group A and B, and the onset time of lactation of women in group C was significant earlier than that of women in group A and B (all P<0.05). The incidence of adverse reactions of women in group A and C was significant lower than that of women in group B (P<0.05). Conclusion: 0.12% ropivacaine combined with 2 g/ml dexmedetomidine has good analgesic effect for pregnant women who want epidural controlled analgesia. It has little effect on their blood pressure and heart rate, and has no obvious adverse effect on the newborn. Moreover, 0.12% ropivacaine combined with 2 g/ml dexmedetomidine for self-control epidural labor analgesia can promote the secretion of PRL with good safe of drugs.

2020 Vol. 28　(11):　1816-1820 [Abstract]（ 409 ） HTML (0 KB)  PDF  (0 KB)  ( 33 )

To investigate the effect of painless visual superconducting abortion for treating women with early scarred uterus pregnancy. Methods: 606 women with early scarred uterus pregnancy were conlected retrospectively, and were divided into two groups according to different ways of terminating pregnancy. 386 women in the observation group had undergone painless visual superconducting abortion, and 220 women in the control group had undergone ordinary induced abortion. The operation situation, the complications rate, and the time of menstrual recovery of women in the two groups were analyzed. Results: The operation time (3.61±1.32 min), the amount of bleeding (12.10±5.31 ml), and the number of times of suction tube entering and leaving the uterine cavity (1.57±0.31 times) of women in the observation group were significant less than those of women in the control group (P<0.05). The total incidence of postoperative complication (3.9%) of women in the observation group was significant lower than that (20.0%) of women in the control group (P<0.05). Compared with those of women in the two groups before operation, the IFN-γlevel of women 30 minutes after operation had decreased, but the IL-10 level had increased significantly, and which’s change of women in the control group were significant higher than those of women in the observation group (P<0.05).  The time of vaginal bleeding and duration of menstrual recovery of women in the observation group were significant shorter than those of women in the control group (P<0.05). Conclusion: Painless visual superconducting abortion for treating women with early scarred uterus pregnancy can effectively shorten the operation time, reduce intraoperative bleeding amount, decrease the risk of postoperative complications. The painless visual superconducting abortion is effective with good safety.

2020 Vol. 28　(11):　1824-1826 [Abstract]（ 337 ） HTML (0 KB)  PDF  (0 KB)  ( 37 )

To understand the prevalence rate and influencing factors of chronic cervicitis of rural women from three prefectures of Sichuan province, and to provide evidences for prevention and treatment strategies of chronic cervicitis of ethnic minority rural women of childbearing age. Methods: The clinical data of 780 married rural women who participated in the free examination of gynecological common diseases in Aba prefecture, Ganzi prefecture and Liangshan prefecture from 2017 to 2019 were analyzed retrospectively. Logistic regression analysis was used to analyze the influence factors of chronic cervicitis. Results: The prevalence of chronic cervicitis of rural women was 15.6%. The education level of their spouse, average family income, and condom used were the protective factors of chronic cervicitis, but menstrual intercourse, abortion frequency, and contraceptive pills used were the risk factors of chronic cervicitis. Conclusion: There are regional differences in the prevalence rate of chronic cervicitis of rural women form Ganzi Prefecture, Aba Prefecture and Liangshan Prefecture in Sichuan Province. And menstrual intercourse, abortion frequency, and contraceptive pills used are the risk factors of chronic cervicitis.

2020 Vol. 28　(11):　1832-1835 [Abstract]（ 282 ） HTML (0 KB)  PDF  (0 KB)  ( 35 )

To analyze the clinical efficacy of Danzhi xiaoyao tablets for treating infertile women with dysfunctional ovulatory by polycystic ovary syndrome (PCOS), and to study its influence on their pregnancy outcomes. Methods: The clinical data of 120 infertile women with dysfunctional ovulatory by PCOS from January 2016 to January 2019 were analyzed retrospectively. According to different treatment, these women were divided into 48 cases in the control group (women with conventional western medicine treatment) and 72 cases in the observation group (women with conventional Western medicine treatment combined with Danzhi Xiaoyao tablet). The sex hormone levels changes, ovarian function, pregnancy outcomes, and adverse reactions of women before and after treatment were compared between the two groups. Results: After treatment, the levels of sex hormones of women in the two groups had increased significantly (P<0.05), the E2 level of women in the observation group (279.86±37.89 pgl/ml) was significant higher than that (255.26±35.33 pgl/ml) of women in the control group, but the levels of T (2.33±0.87 pmol/ml), FSH (5.21±0.88 mlu/ml), and LH (11.48±1.46 mlu/ml) of women in the observation group were significant lower. After treatment, the ovarian condition of women in both groups had improved significantly (P<0.05), the number of dominant follicles and the diameter of the dominant follicles of women in the observation group were significant better than those of women in the control group. After treatment, the diameter of follicles (8.93±0.45mm) and endometrial thickness in luteal stage (12.38±0.46mm) of women in the observation group were significant higher than those of women in the control group. After treatment, the proportion of endometrium in type A (69.4%) and the pregnancy rate (55.6%) of women in the observation group were significant higher than those (31.3% and 35.4%) of women in the control group (P<0.05). There was no significant difference in the miscarriage rate of women between the two groups (P>0.05), and the total incidence of adverse reactions (2.78%) of women in the observation group had no significant different from that (2.08%) of women in the control group (P>0.05). Conclusion: Danzhi xiaoyao tablet combined with conventional western medicine for treating women with dysfunctional ovulatory by PCOS has significant clinical effect, which can increase improve their sex hormone levels, ovulation rate, and pregnancy rate with high safety.

2020 Vol. 28　(11):　1840-1843 [Abstract]（ 366 ） HTML (0 KB)  PDF  (0 KB)  ( 31 )

To explore the human body composition analysis of women with premature ovarian insufficiency. Methods: 90 women with POI were enrolled in observation group, and 90 women of childbearing age with normal ovarian function were recruited in control group during the same period from May 2017 to May 2019. The women in the observation group were then divided into three groups according to their estradiol (E2) level, which included the women with E2 level less than 74pmo/l in group A, the women with E2 level between 74-148pmol/L in group B, and the women with E2 level higher than 148pmol/L in group C. The body composition indexes of women were compared among these groups. Results: The values of body weight and body mass index (BMI) of women in the observation group were 58.78±11.91 kg and 23.12±4.26 kg/m2, which were significant higher than those (52.79±5.45 kg and 20.11±1.39 kg/m2) of women in the control group (P＜0.05). The values of body fat content, body fat rate, and visceral fat area of women in the observation group were 20.4±7.8 kg, 33.7±7.4%, and 81.09±27.75cm2, which were significant higher than those (13.4±1.9 kg, 25.3±2.3%, and 55.2±9.1 cm2) of women in the control group (P＜0.05). There were no statistically significant differences in the values of fat free mass, protein, and muscle weight of women between the observation group and control group (P＞0.05). The values of body weight, BMI, body fat content, body fat rate, and visceral fat area in group A were 51.9±11.5kg, 20.9±4.2kg/m2, 16.56±7.27kg, 30.8±7.9%, and 66.48±25.79 cm2, respectively, which were significant higher than those (52.79±5.45 kg and 20.11±1.39 kg/m2) of women in group B and C (P＜0.05), but those of women had no significant difference between group B and group C (P＞0.05). Conclusion: The values of body fat related indicators of women with POI are significant higher than those of normal women. And the values of body fat related indicators of women with POI and E2≥74pmol/L are higher. This study suggests that the nutritional status and nutrition intervention of women with POI should be emphasized in clinical practice in order to reduce the risk of potential metabolic diseases.

2020 Vol. 28　(11):　1848-1851 [Abstract]（ 356 ） HTML (0 KB)  PDF  (0 KB)  ( 31 )

To explore the efficacy factors of prophylactic cervical cerclage for treating women with cervical incompetence, and to study it’s influencing on prognostic. Methods: From March 2017 to March 2019, 65 women with cervical incompetence who had accepted prophylactic cervical cerclage were in study group, and 65 patients with cervical incompetence who had accepted therapeutic cervical cerclage were in control group during the same period. The bleeding amount during operation, postoperative hospital stay time, gestational weeks when delivery, cervical length in the 32rd gestational week, pregnancy outcomes, extension gestational weeks after operation, or neonatal situations of women was compared between the two groups. The influencing factors of curative effect of women in the two groups were also analyzed. Results: After operation, the amount of bleeding (27.3±5.7 ml) and postoperative hospital stay (6.6±2.2 d) of women in the study group were significant lower than those of women in the control group, but the gestational weeks when delivery (37.8±4.2 weeks), cervical length in the 32rd gestational week (3.1±0.2 cm), the rate of full-term delivery (88.9%), extension gestational week after operation (9.5±2.5 weeks), neonatal body weight (2879.34±235.64g), and neonatal survival rate (92.3%) of women in the study group were significant higher (all P<0.05). The therapeutic effects of women in the study group were significantly correlated with their age and preoperative invasive manipulation (P<0.05), but were not correlated with perioperative progesterone used, the history of cervical surgery, the history of premature delivery or late abortion, and the operation time (P>0.05). Older pregnant women and invasive manipulation before operation were independent risk factors of preventive cervical cerclage (P<0.05). Conclusion: Prophylactic cervical cerclage for treating women with cervical incompetence can significantly reduce the amount of bleeding during operation and postoperative hospital stay time, prolong gestational weeks, improve full-term delivery rate, and improve neonatal survival rate and quality, which’s curative effect is affected by the age of women and preoperative invasive manipulation.

2020 Vol. 28　(11):　1856-1859 [Abstract]（ 256 ） HTML (0 KB)  PDF  (0 KB)  ( 33 )

To analyze the clinical efficacy of modified natural cycle for treating women with ovarian reserve dysfunction. Methods: The clinical data of 89 women with ovarian reserve dysfunction were analyzed retrospectively. According to assisted reproductive protocol, these women were divided into three group, which included women accepted the modified natural cycle in group A，women accepted the ovulation induction in high level of progestational hormone in group B, and women accepted the micro stimulation in group C. The levels of basic sex hormones, treatment-related conditions, and clinical outcomes of women in the three groups were recorded. Results: There were no significant difference in the levels of basic sex hormones of women among the three groups before the start of the protocol (P>0.05). The E2 level on the HCG day, the number of oocytes obtained, and the number of usable embryos of women in group A were significant lower than those of women in the other two groups, but the LH level and the highest LH level on the HCG day and the rate of no oocytes obtained of women in group A were significant higher than those in the other two groups（P<0.05）. The single cycle clinical pregnancy rate (8.7%) of women in group A had no significant different from that (6.3%) of women in group B and that (8.0%) of women in C. The accumulated clinical pregnancy rate (20.0%) of women in group A had no significant different from that (17.9%) of women in group B and that (24.3%) of women in C (all P>0.05). Conclusion: The modified natural cycle scheme can be used for women with poor ovarian reserve function, although the cycle cancellation rate of which is high and the egg acquisition rate of which is low, it has advantages such as simple operation and economy, and the clinical pregnancy rate is relatively satisfactory. However, it was necessary to grasp the timing of egg obtaining in clinical practice.

2020 Vol. 28　(11):　1864-1867 [Abstract]（ 269 ） HTML (0 KB)  PDF  (0 KB)  ( 36 )

To analyze pregnancy outcomes and related factors of women after hysteroscopic endometrial polypectomy. Methods: 225 infertility women with endometrial polyps were selected and were given hysteroscopic endometrial polypectomy in the past two years. The pregnancy outcomes of these women in 12 and 24 months after operation were analyzed. Results: The normal delivery rate and the natural pregnancy rate (21.3% and 24.0%) of these women in the 24th month after surgery were significant higher than those (13.3% and 20.0%) of these women in the 12th month after surgery (P<0.05). Multivariate logistic regression analysis indicated that age ≥30 years old, number of polyp ≥2, polyp diameter ≥1cm, polyp site in posterior wall or uterine corners, body mass index (BMI) ≥28kg/m2, history of diabetes and secondary infertility could influence postoperative pregnancy outcomes (P<0.05). Conclusion: Hysteroscopic polypectomy for treating women with endometrial polyps has good clinical effect and pregnancy outcomes, and the pregnant effect and natural delivery rate of women in 24 months after operation are better. Age, number of polyps, polyp diameter, polyp location, BMI, history of diabetes mellitus, and type of infertility influence the pregnancy outcomes.

2020 Vol. 28　(11):　1872-1875 [Abstract]（ 356 ） HTML (0 KB)  PDF  (0 KB)  ( 30 )

To investigate the correlation between serum levels of irregular chemokines (Fractalkine) and fat-specific serine protease inhibitors (Vaspin) and cardiac function of pregnant women with severe preeclampsia. Methods: 84 pregnant women with severe preeclampsia from January 2016 to July 2019 were selected retrospectively in observation group, and 50 normal pregnant women were selected in control group during the same period. The serum levels of Fractalkine and Vaspin, and cardiac function index of women were compared between the groups. Pearson correlation analysis and multiple linear regression analysis were performed. Results: The serum Fractalkine level (402.57±78.69 pg/ml) of women in the observation group was significant higher than that (153.27±76.53 pg/ml) of women in the control group, but the Vaspin level (6.27±1.48) of women in the observation group was significant lower than that (7.32±2.13) of women in the control group (P<0.05). The left ventricular ejection fraction (LVEF) value (58.37±4.72%) and E/A value (0.71±0.21) of women in the observation group were significant lower than those of women in the control group, but the Tei index value (0.57±0.04) of women in the observation group was significant higher (P<0.05). Pearson correlation analysis had showed that Fractalkine level was negatively correlated with the values of LVEF and E/A of women in the observation group, and was positively correlated with the Tei index value (P<0.05). The Vaspin level was positive with the values of LVEF and E/A of women in the observation group, and was negatively correlated with Tei index value (P<0.05). Multiple linear regression analysis had showed the levels of Fractalkine and Vaspin were independent factors affecting cardiac function of women with severe preeclampsia. Conclusion: Serum Fractalkine and Vaspin levels are directly related to cardiac function of women with severe preeclampsia, which are expected to be the reference indexes for clinical diagnosis and treatment of severe preeclampsia.

2020 Vol. 28　(11):　1880-1883 [Abstract]（ 424 ） HTML (0 KB)  PDF  (0 KB)  ( 28 )

To explore relationship between the situation of vaginal group B streptococcus (GBS) and factor-α (TNF-α) expression of pregnant women with premature rupture of membranes and their neonatal adverse outcomes. Methods: 55 pregnant women with premature rupture of membranes were selected in observation group from February 2016 to September 2018, another 50 normal pregnant women were selected in control group during the same period. The vaginal swab specimens of women in both groups were collected, and GBS was detected by polymerase chain amplification (PCR) method and TNF-αlevel was detected by immunoturbidimetry method. The positive rates of GBS and TNF-α and neonatal delivery situation in the two groups were analyzed. Results: The positive rates of GBS and TNF-αof women in the observation group were 27.3% and 29.1%, which were significant higher than those (6.0% and 8.0%) of women in the control group (P<0.05). In the observation group，the incidences of neonatal pneumonia, neonatal asphyxia, fetal distress, and preterm birth of women with GBS positive and TNF-αpositive were significant higher than those of women with GBS negative and TNF-αnegative (P<0.05). In the 105 women, the incidences of neonatal pneumonia, neonatal asphyxia, fetal distress, and preterm birth of women with GBS positive and TNF-αpositive were significant higher than those of women with GBS negative and TNF-αnegative (P<0.05). Conclusion: The GBS and TNF-αsituation of these pregnant women have certain relation with their premature rupture of membranes occurrence, so early treatment can reduce adverse pregnancy outcomes of them in clinical practice.

2020 Vol. 28　(11):　1887-1889 [Abstract]（ 306 ） HTML (0 KB)  PDF  (0 KB)  ( 35 )

To investigate the value of A wave inversion of venous catheter combined with fetal nuchal translucency (NT) value for screening fetal chromosomal aneuploidy of pregnant women during the first trimester of pregnancy. Methods: From January 2016 to September 2019, 2086 pregnant women who received NT ultrasound examination during 11-13 gestational weeks were selected as the study objects, and all these women were given the examination of blood flow spectrum of fetal venous catheter and fetal NT. The diagnosis "gold standard" was based on the delivery outcomes or induction outcomes. The abnormal chromosome aneuploidy of fetus was recorded. The blood flow spectrum of fetal venous catheter and the fetal NT value by ultrasound were analyzed, and which’s efficiency for predicting fetal aneuploidy was also analyzed. Results: According to the results of delivery or induced labor, 34 cases with chromosomal aneuploidy were found in 2086 fetuses. In 41 fetuses with A wave inversion of fetal venous catheter were found by ultrasound examination, 27 (65.9%) cases with chromosomal aneuploidy were identified. In 47 fetuses with thick NT were found by ultrasound examination, 28 (59.5%) cases with chromosomal aneuploidy were identified. In 39 fetuses with thick NT and A wave inversion of fetal venous catheter were found by ultrasound examination, 31(79.5%) cases with chromosomal aneuploidy were identified. The sensitivity (79.4% or 58.8%), the specificity (99.3% or 98.7%), the accuracy (99.0% or 98.0%), the positive predictive value (65.9% or 42.6%), and the negative predictive value (99.7% or 99.3%) of A wave inversion of venous catheter or NT thickening for diagnosing fetal chromosomal aneuploidy were all significant lower that those (91.2%, 99.6%, 99.5%, 79.5%, and 99.9%, respectively) of A wave inversion of venous catheter combined with NT thickening (P<0.05). Conclusion: The results of A wave inversion of venous catheter combined with NT value of fetus detected by ultrasound during the first trimester of pregnancy for screening of chromosomal aneuploidy can significantly improve the diagnostic sensitivity, specificity and accuracy, which can provide effective evidence for clinical accurate judgment and timely treatment of fetal chromosomal abnormalities.

2020 Vol. 28　(11):　1894-1897 [Abstract]（ 284 ） HTML (0 KB)  PDF  (0 KB)  ( 35 )

To investigate the expression levels of serum carbohydrate antigen 199 (CA199), vascular endothelial growth factor (VEGF), and human epididymis protein 4 (HE4) of women with endometrial carcinoma (EC), and to study their diagnostic values for lymph node metastasis of EC. Methods: 94 women with EC were selected in observation group and 90 women with endometrial hyperplasia were selected in control group from February 2016 to March 2019. The expression of serum CA199 was measured by automatic chemiluminescence analyzer, and the serum expressions of serum VEGF and HE4 were detected by enzyme linked immunosorbent assay (ELISA). The relationships between the expression levels of CA199, VEGF, HE4 and the clinicopathological characteristics of women with EC was analyzed, and ROC curve was used to evaluate the value of expression levels of CA199, VEGF and HE4 for diagnosing the lymph node metastasis of EC. Results: The expression levels of serum CA199 (37.44±21.23 kU/L), VEGF (236.48±53.44 ng/L), and HE4 (47.12±10.59 pmol/L) of women in the observation group were significant higher than those of women in the control group (P<0.05). The levels of serum CA199, VEGF and HE4 of women with EC were related to their TNM stage, differentiation degree, and lymph node metastasis. And in the observation group, the expression levels of serum CA199, VEGF and HE4 of women with lymph node metastasis were significant higher than those of women without lymph node metastasis (P<0.05). The area under ROC curve of CA199 level, VEGF level, and HE4 level for diagnosing EC alone were 0.678, 0.739 and 0.728, respectively, the sensitivity of CA199 level, VEGF level, and HE4 level for diagnosing EC alone were 66.7%, 66.7%, and 58.3%, respectively, and the specificity of CA199 level, VEGF level, and HE4 level for diagnosing EC alone were 70.7%, 79.3% or 79.3%, respectively. And the area under ROC curve, the sensitivity, and the specificity of combination of CA199, VEGF and HE4 levels for diagnosing EC were 0.800, 86.1%, and 63.8%, respectively. Conclusion: The expression levels of serum CA199, VEGF and HE4 of women with EC and lymph node metastasis are high, combination of CA199, VEGF and HE4 levels for diagnosing lymph node metastasis of women with EC have certain value.

2020 Vol. 28　(11):　1901-1904 [Abstract]（ 277 ） HTML (0 KB)  PDF  (0 KB)  ( 36 )

To analyze the status of pregestational malnutrition, and overweight or obesity of pregnant women in Shanghai. Methods: Based on the health data of the first prenatal examination of 482899 pregnant women from Shanghai Maternal Health Care System between 2013 and 2015, variance analysis and chi-square test were used to analyze the prevalence and variation trends of pregestational malnutrition, and overweight or obesity of pregnant women. Results: The overall progestational malnutrition rate of pregnant women was 12.9% in Shanghai from 2013 to 2015, which had a decreasing trend year by year, especially that (16.3%) of women aged 19-25 was the highest. The overall overweight rate and obesity rate before pregnancy were 9.8% and 2.5%, respectively, with increasing trends of both overall overweight rate and obesity rate year by year. There were statistically significant differences in pregestational nutritional status among women of different ages, household registration, educational background, occupation, gravidity and parity history. Conclusion: It is important to pay more attention to the significant nutritional deficiency of women under 25 years old, and the overweight or obesity of elderly and second-born mothers in Shanghai.

2020 Vol. 28　(11):　1909-1913 [Abstract]（ 275 ） HTML (0 KB)  PDF  (0 KB)  ( 34 )

To explore the application effect of the software on“Individualized Diagnosis and Treatment System for Severe Postpartum Hemorrhage Based on Fuzzy Theory” . Methods: The data of 179 women with severe postpartum hemorrhage from January 2015 to December 2017 in the affiliated Jiangyin hospital of southeast university medical college were selected. The grade, cause, and proportion of postpartum hemorrhage of these women were retrospectively analyzed by the software on “individualized diagnosis and treatment system for severe postpartum hemorrhage based on fuzzy theory”, and analytic results were compared with those in clinical practice. Results: In the 179 women with severe postpartum hemorrhage, 6 (3.4%) women were in low risk, 13 (7.3%) women were in moderate risk, 48 (27.0%) women were in high risk, and 112 (62.6%) women were in very high risk. The main causes of clinical hemorrhage were uterine atony, placental factors, soft birth canal injury, and so on. 76.0% parturient women with uterine inertia diagnosed by this software was significant more than that (62.6%) of the clinical reality situation (P<0.05), but 12.8% parturient women with placental factors diagnosed by this software was significant less than that (24.6%) of the clinical reality situation (P<0.05). There were no significant difference in soft birth canal injury rate (10.6% vs.10.1% ) and coagulation dysfunction rate (2.8% vs.2.8%) between diagnosed by this software and that of clinical reality situation (P>0.05). The risk grade of women with cesarean and bleeding volume (1302±658 ml) of women with very high risk grade and cesarean were significant higher than those of women with natural delivery (P<0.05). Conclusion: “Individualized diagnosis and treatment system for severe postpartum hemorrhage based on fuzzy theory” can comprehensively analyze and predict the cause and risk grades of severe postpartum hemorrhage, and can evaluate the risk grades and bleeding degree of women with different delivery modes, so it has certain clinical value.

2020 Vol. 28　(11):　1917-1921 [Abstract]（ 353 ） HTML (0 KB)  PDF  (0 KB)  ( 35 )

To detect the susceptibility genes of deafness of population with deafness or high-risk by the technology of deafness gene chip, to explore the genetic mutation characteristics of gene of hereditary deafness in Lishui district of Nanjing city, and to provide reference for the prevention and consultation of hereditary deafness. Methods: A total of 200 cases with deafness or deaf high-risk in Lishui district were collected and were divided into 102 cases in the deaf group and 98 cases in the high-risk group. The 15 locus pathogenic variants of four genes of all cases were screened and analyzed. Results: Among the 200 samples of these cases, there were 66 cases (33.0%, 66/200) with known pathogenic deafness genes, which included 47 cases (46.1%, 47/102) from the deafness group, and 19 cases (19.4%, 19/98) from the high risk group. Among the positive results of 66 cases, the detection rate of GJB2 gene mutation SLC26A4 gene mutation, mitochondrial 12SrRNA gene mutation, and GJB3 gene mutation were 11.5%, 9.5%, 12.5%, and 0%, respectively. Conclusion: The mutations of deafness gene of people in Lishui district have obvious regional characteristics. The highest rate of hot spot mutations is from mitochondrial 12SrRNA gene and the most of them is 1555 A＞G gene mutation.

2020 Vol. 28　(11):　1926-1928 [Abstract]（ 330 ） HTML (0 KB)  PDF  (0 KB)  ( 32 )