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| Effect and correlation analysis of the levels of plasma Hcy, TNF-α, and folic acid of women with missed abortion |
| Qinhuai Medical District, General Hospital of Eastern Theater Command,PLA, Nanjing, Jiangsu Province, 210002 |
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Abstract To investigate the levels and correlation of plasma Hcy, TNF-α, and folic acid level of women with missed abortion. Methods: 48 women with missed abortion were selected in observation group, and 48 normal pregnant women who had received induced abortion during the first trimester of pregnancy were selected in control group from January 2018 to October 2019. The plasma levels of Hcy, folic acid and TNF-α of women in the two groups were detected, and the correlation of them was analyzed. Results: The levels of Hcy (6.2±0.3 mol/L) and TNF-α (43.5±4.1) of women in the observation group were significant higher than those (4.4±0.3 mol/L and 12.5±3.2) of women in the control group, but the level of folic acid (14.5±3.2 nmol/L) of women in the observation group was significant lower than that (16.7±2.3 nmol/L) of women in the control group (P<0.05). Hcy level was positively correlated with their TNF-αlevel, while folic acid level was negatively correlated with their Hcy and TNF-α levels (all P<0.05). Conclusion: The level of Hcy of women with missed abortion has increased, but their folic acid level has decreased, which maybe cause the strong inflammatory response of the body, and the chronic inflammation is one of the reason of missed abortion.
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