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| Clinical efficacy of different doses of mifepristone for treating uterine leiomyoma |
| Pukou Hospital of Traditional Chinese Medicine, Pukou District, Nanjing, Jiangsu Province, 211800 |
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Abstract To compare the clinical efficacy of different doses of mifepristone for treating women with uterine leiomyoma. Methods: 2000 women with uterine leiomyoma were selected and divided into group A (972 women given mifepristone 25.0mg/d) and group B (1028 women given mifepristone 12.5mg/d) from January 2017 to December 2018. The therapeutic effect, serum hormone levels before and after treatment, and adverse reaction rate of women were compared between the two groups. Results: The total effective rate of women in group B were 95.1%, which was significant higher than that (92.7%) of women in group A, but the incidence of adverse reactions of women in group B was 1.2%, which was significant lower than that (6.6%) of women in group A (P<0.05). There were no difference in the levels of follicle stimulating hormone, luteinizing hormone, estrogen, and progesterone of women between the two groups (P>0.05). Conclusion: The effect of lowdose mifepristone for treating women with uterine leiomyoma is better, which has less adverse reactions and higher clinical effect.
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