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| Etiology of women with recurrent miscarriage and the analysis of chromosomal abnormalities of embryos after abortion |
| The First Hospital of Jiaxing City, Zhejiang Province, 314000 |
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Abstract To investigate the etiology constitute of women with recurrent miscarriage (RM), to analyze the chromosomal abnormalities of embryos after abortion, and to provide evidence for reducing the subsequent abortion rate. Methods: 180 women with RM ≥ 2 times were enrolled in study group, and 180 healthy women with live birth and without abortion history were included in control group from May 2016 to May 2019. And the etiology and embryonic chromosomal abnormalities of women in the study group were analyzed. The clinical indicators of women in the two groups were observed. Logistic regression analysis was used to analyze the influence factors of RM. Results: In the study group, there were 117 (60.9%) women with chromosomal abnormalities of aborted fetus, 57 (31.7%) women had identified etiology, which included 35 (19.4%) women with advanced age, 4(2.2%) women with obesity, 12(6.7%) women with chromosomal abnormalities, 15(8.3%) women with uterus abnormalities, 23(12.8%) women with endocrine abnormalities, and 6(3.3%) women with antiphospholipid antibody syndrome. And in 117 cases with most common chromosome trisomy, there were 23(19.7%) cases with 16 trisomy, then there were 13(11.1%) cases with 22 trisomy followed, and then there were 12 (10.3%) cases with 15 trisomy. Multivariate regression analysis showed that manual workers, toxic decoration or chemical materials exposure, PM2.5 contamination, and TORCH infection were independent risk factors for RM except to the routine etiology and progeny chromosome abnormalities (P<0.05). Conclusion: Embryonic chromosomal abnormalities are the most common cause of RM, so prenatal diagnosis should be strengthened for high-risk pregnant women to reduce the later SM and to promote better rearing children.
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