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Abstract To explore the related factors of early spontaneous abortion of infertile women after in vitro fertilization embryo transfer (IVF-ET). Methods: The clinical data of 110 infertile women after IVF-ET were analyzed retrospectively. All these women were divided into group A (21 women with abortion) and group B (89 women without abortion). The main clinical data of women were compared between the two groups. ROC curve was used to find the cut off value, and the relationship between different single factor and abortion rate was compared. Multivariate logistic regression was used to analyze the independent risk factors of early spontaneous abortion. Results: The age, BMI, infertility duration, and D-Dimer level of women in group A were significant higher than those of women in group B. The thickness of endometrium and the hCG level 14 days after transplantation of women in group A were significant lower than those of women in group B (all P<0.05). There were no significant different in the rates of oviduct obstruction and ovulation disturbance, and the number of superior embryos, the number of embryo transplant, cycle type of embryo transplanted, days of gonadotropin use, the levels of FSH, E2, PRL and LH on start-up day, and the levels of TSH, FT3, FT4, and antithyroid peroxidase antibody (TPOAb) on the 14th day after transplantation between the two groups (P>0.05). ROC curve analysis showed that the cut-off value of age, body mass index, infertility duration, endometrial thickness, and D-dimer level was 33 years old, 23 kg/m2, 5 years, 11 mm, 583 IU/L, 500 ng/ml, respectively. According to the cut off value of age, body mass index, infertility duration, endometrial thickness, or D-dimer level, 110 women was divided into two groups, and there were significant different in age, body mass index, endometrial thickness, hCG level 14 days after transplantation, and D-dimer level 7 days after transplantation (P<0.05). Multivariate logistic regression analysis showed that age, endometrial thickness, hCG level, and D-dimer level were correlated with the early spontaneous abortion occurrence (P<0.05). Conclusion: The infertile women with age > 33 years old, endometrial thickness ≤ 11mm, hCG level ≤ 583 IU/ L 14 days after transplantation, and D-dimer level >500ng/ml 7 days after transplantation are independent risk factors for early spontaneous abortion after IVF-ET.
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