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Abstract To investigate the expression levels of serum carbohydrate antigen 199 (CA199), vascular endothelial growth factor (VEGF), and human epididymis protein 4 (HE4) of women with endometrial carcinoma (EC), and to study their diagnostic values for lymph node metastasis of EC. Methods: 94 women with EC were selected in observation group and 90 women with endometrial hyperplasia were selected in control group from February 2016 to March 2019. The expression of serum CA199 was measured by automatic chemiluminescence analyzer, and the serum expressions of serum VEGF and HE4 were detected by enzyme linked immunosorbent assay (ELISA). The relationships between the expression levels of CA199, VEGF, HE4 and the clinicopathological characteristics of women with EC was analyzed, and ROC curve was used to evaluate the value of expression levels of CA199, VEGF and HE4 for diagnosing the lymph node metastasis of EC. Results: The expression levels of serum CA199 (37.44±21.23 kU/L), VEGF (236.48±53.44 ng/L), and HE4 (47.12±10.59 pmol/L) of women in the observation group were significant higher than those of women in the control group (P<0.05). The levels of serum CA199, VEGF and HE4 of women with EC were related to their TNM stage, differentiation degree, and lymph node metastasis. And in the observation group, the expression levels of serum CA199, VEGF and HE4 of women with lymph node metastasis were significant higher than those of women without lymph node metastasis (P<0.05). The area under ROC curve of CA199 level, VEGF level, and HE4 level for diagnosing EC alone were 0.678, 0.739 and 0.728, respectively, the sensitivity of CA199 level, VEGF level, and HE4 level for diagnosing EC alone were 66.7%, 66.7%, and 58.3%, respectively, and the specificity of CA199 level, VEGF level, and HE4 level for diagnosing EC alone were 70.7%, 79.3% or 79.3%, respectively. And the area under ROC curve, the sensitivity, and the specificity of combination of CA199, VEGF and HE4 levels for diagnosing EC were 0.800, 86.1%, and 63.8%, respectively. Conclusion: The expression levels of serum CA199, VEGF and HE4 of women with EC and lymph node metastasis are high, combination of CA199, VEGF and HE4 levels for diagnosing lymph node metastasis of women with EC have certain value.
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