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| Research progress of the relationship between the long non coding RNA and the recurrent miscarriage or repeated implantation failure of the fertilized egg |
| 1. University of Traditional Chinese Medicine, Harbin, Heilongjiang Province,150040; 2. The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine |
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Abstract Currently, the study on long non coding RNA (lnc RNA) has been rising rapidly. It has become a hotspot in epigenetics due to its diverse mechanisms and powerful biological functions. More and more studies have reported that lnc RNA has been involved in some female reproductive diseases by regulating the expression of target genes. Among them, the relationship between the lnc RNA and miscarriage related diseases has been paid more attention by scholars. The authors systematically review the relevant literature published at home and abroad in recent 10 years, and investigate the effect of lnc RNA on the regulation of embryonic, placenta development, endometrial receptivity, and embryo and maternal interaction on the recurrent miscarriage or repeated implantation failure of the fertilized egg, so as to offer a new direction for further research of epigenetics.
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