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| Clinical efficacy of modified naturalcycle for treating women with ovarian reserve dysfunction |
| Northwest Women's and Children's Hospital, Xian City, Shaanxi Province, 710003 |
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Abstract To analyze the clinical efficacy of modified natural cycle for treating women with ovarian reserve dysfunction. Methods: The clinical data of 89 women with ovarian reserve dysfunction were analyzed retrospectively. According to assisted reproductive protocol, these women were divided into three group, which included women accepted the modified natural cycle in group A，women accepted the ovulation induction in high level of progestational hormone in group B, and women accepted the micro stimulation in group C. The levels of basic sex hormones, treatment-related conditions, and clinical outcomes of women in the three groups were recorded. Results: There were no significant difference in the levels of basic sex hormones of women among the three groups before the start of the protocol (P>0.05). The E2 level on the HCG day, the number of oocytes obtained, and the number of usable embryos of women in group A were significant lower than those of women in the other two groups, but the LH level and the highest LH level on the HCG day and the rate of no oocytes obtained of women in group A were significant higher than those in the other two groups（P<0.05）. The single cycle clinical pregnancy rate (8.7%) of women in group A had no significant different from that (6.3%) of women in group B and that (8.0%) of women in C. The accumulated clinical pregnancy rate (20.0%) of women in group A had no significant different from that (17.9%) of women in group B and that (24.3%) of women in C (all P>0.05). Conclusion: The modified natural cycle scheme can be used for women with poor ovarian reserve function, although the cycle cancellation rate of which is high and the egg acquisition rate of which is low, it has advantages such as simple operation and economy, and the clinical pregnancy rate is relatively satisfactory. However, it was necessary to grasp the timing of egg obtaining in clinical practice.
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