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| Correlation between serum Fractalkine and Vaspin levels and cardiac function of pregnant women with severe preeclampsia |
| Mianyang Central Hospital, Mianyang City, Sichuan Province, 621000 |
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Abstract To investigate the correlation between serum levels of irregular chemokines (Fractalkine) and fat-specific serine protease inhibitors (Vaspin) and cardiac function of pregnant women with severe preeclampsia. Methods: 84 pregnant women with severe preeclampsia from January 2016 to July 2019 were selected retrospectively in observation group, and 50 normal pregnant women were selected in control group during the same period. The serum levels of Fractalkine and Vaspin, and cardiac function index of women were compared between the groups. Pearson correlation analysis and multiple linear regression analysis were performed. Results: The serum Fractalkine level (402.57±78.69 pg/ml) of women in the observation group was significant higher than that (153.27±76.53 pg/ml) of women in the control group, but the Vaspin level (6.27±1.48) of women in the observation group was significant lower than that (7.32±2.13) of women in the control group (P<0.05). The left ventricular ejection fraction (LVEF) value (58.37±4.72%) and E/A value (0.71±0.21) of women in the observation group were significant lower than those of women in the control group, but the Tei index value (0.57±0.04) of women in the observation group was significant higher (P<0.05). Pearson correlation analysis had showed that Fractalkine level was negatively correlated with the values of LVEF and E/A of women in the observation group, and was positively correlated with the Tei index value (P<0.05). The Vaspin level was positive with the values of LVEF and E/A of women in the observation group, and was negatively correlated with Tei index value (P<0.05). Multiple linear regression analysis had showed the levels of Fractalkine and Vaspin were independent factors affecting cardiac function of women with severe preeclampsia. Conclusion: Serum Fractalkine and Vaspin levels are directly related to cardiac function of women with severe preeclampsia, which are expected to be the reference indexes for clinical diagnosis and treatment of severe preeclampsia.
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