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| Relationship between serum EGF and TIMPs levels and uterine fibroids |
| Jinan Hospital, Shandong Province, 250014 |
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Abstract To investigate the relationship between change of serum epidermal growth factor (EGF) and tissue inhibitor of metalloproteinases (TIMPs) levels of women and the occurrence and development of their uterine fibroids. Methods: 110 women with uterine fibroids were selected in study group, and 110 healthy women were selected in the control group. The serum EGF and TIMPs levels of women were compared between the two groups. The serum EGF and TIMPs levels were compared between the women with different fibroid size, fibroid position, or fibroid diameter. Results: The serum EGF level of women in the study group was 343.8±82.0 pg/ml, which was significant higher than that of women in the control group (P＜0.05). The serum levels of TIMP2 and TIMP9 of women in the study group were 226.6±67.1 ng/ml and 165.8±33.0 ng/ml, which were significant lower than those of women in the control group (P＜0.05). In the study group, the serum EGF level of women with submucosal myoma was significant higher than that of women with muscle wall, the serum TIMP2 level of women with multiple uterine fibroids was significant lower than that of women with single uterine fibroid, and the serum TIMP2 level of women with diameter of uterine fibroids ＞6.0cm was significant lower than that of women with diameter of uterine fibroids ≤6.0cm (all P＜0.05). Conclusion: The serum EGF level of women with uterine fibroids increases, but the TIMPs level decreases, which all have a certain relationship with the development of uterine fibroids.
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