Objective: To investigate the expression and function localization of microtubule associated protein tau in mouse ovarian granulosa cells. Methods: 12 female mice were selected, which included 6 adult mice and 6 juvenile mice, and their ovarian granulosa cells were collected and cultured. The granulosa cells of these mice were cultured with or without FSH, and immunohistochemical staining was used to observe the expression of microtubule associated protein tau in the granulosa cells. Then Tau fusion protein was transfected into the granulosa cells, and the localization of tau in the granulosa cells was observed by fluorescence microscopy. Results: The positive expression of tau protein in the ovarian granulosa cells of the adult was significant higher than that of juvenile mice. Among the adult mouse, the positive expression of tau protein in the granulosa cells cultured with FSH was significant higher than that of cells cultured without FSH (P<0.05). Among the juvenile mouse, the positive expression of tau protein in ovarian granulosa cells of cultured with FSH was significant higher than that of ovarian granulosa cells cultured without FSH (P<0.05). Tau protein of ovarian granulosa cells of adult mice was aggregated in nucleus and was radiated. Conclusion: The microtubule associated protein Tau can be highly expressed in ovarian granulosa cells of adult mouse, and its localization is mainly concentrated in the nucleus. The expression and localization of tau can reflect the formation and morphological changes of microtubules, which affect the proliferation and differentiation of microtubule of granulosa cells.

2019 Vol. 27　(9):　1133- [Abstract]（ 408 ） HTML (0 KB)  PDF  (0 KB)  ( 40 )

Objective: To explore the curative efficacy of Fugongning granule combined with medroxyprogesterone acetate for treating women with endometriosis, and to study its effects on levels of serum follicostatin (FS), soluble intercellular adhesion molecule (sICAM1) and soluble leukocyte 2 receptor (sIL2R). Methods: 124 women with endometriosis were selected as research objects and were divided into group A and group B by random number table from February 2015 to February 2018. 61 women in group A were treated by progesterone for 3 months, and 63 women in group B were treated by Fugongning granule combined with medroxyprogesterone acetate for 3 months. The clinical efficacy, the changes of hormones index, TCM syndrome score and adverse reaction rate were compared between the two groups. Results: The total effective rate and the estradiol (E2) level of women in group B were 93.7% and 587.56±39.50pg/ml, which were significant higher than those (80.3% and 514.91±34.85pg/ml) of women in group A, but the serum levels of follicular estrogen (FSH), luteinizing hormone (LH), FS, sICAM1, sIL2R and TCM syndrome scores of women in group B were 4.92±0.58U/L, 7.12±1.08U/L, 237.31±20.08ng/L, 271.28±16.74ng/ml, 245.82±18.54ng/ml, and 3.9±0.8 scores, respectively, which were significant lower than those (7.69±0.73U/L, 9.05±1.24U/L, 324.48±25.61ng/L, 304.53±18.39ng/ml, 288.39±20.91ng/ml, and 5.4±0.9 scores, respectively) of women in group A (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (4.8% VS. 3.3%, P>0.05). Conclusion: Fugongning granule combined with medroxyprogesterone acetate for treating women with endometriosis has good efficacy, which can effectively reduce the expression of serum FS, sICAM1 and sIL2R levels and can promote the recovery of disease.

2019 Vol. 27　(9):　1142- [Abstract]（ 421 ） HTML (0 KB)  PDF  (0 KB)  ( 37 )

Objective: To analyze the influence of gonadotropinreleasing hormone agonist (GnRHa) combined with addback therapy on the levels of serum sex hormones, calcium and phosphate, and endometrium of women with endometriosis (EMT) at stage III and IV. Methods: 270 women with EMT at stage III and IV were selected and were randomly divided into group A, B and C (90 cases in each group) from June 2013 to June 2018. Women in group A were treated by GnRHa and addback add tibolone, women in group B were given GnRHa and addback estradiol valerate, and women in group C were given GnRHa only. All women were treated for 3 months. The modified Kupperman index (KMI), perimenopausal symptoms, levels of serum estradiol (E2), folliclestimulating hormone (FSH), luteinizing hormone (LH), calcium, and phosphate, endometrial changes under ultrasound, the incidence of adverse reaction, recurrence rate, and pregnancy rate of women were compared among the three groups. Results: KMI score of women in group A or group B were significant lower than those of women in group C in 1 month or 3 months after treatment (P<0.01). The serum calcium level of women in group A or group B was significant higher than that of women in group C after treatment, while levels of E2, FSH, LH and phosphate were significant lower (P<0.01). The endometrial thickness of all women in the three groups significantly decreased after treatment (P<0.01), but there was no significant difference in endometrial thickness among the three groups (P>0.05). The incidence of adverse reaction of women in group A or group B was 3.3% or 4.4%, which was significant lower than that (13.3%) of women in group C, while the pregnancy rate of women in group A or group B was 50.0% or 51.1%, which was significant higher than that (33.3%) of women in group C (P<0.05). There was no significant difference in the recurrence rate among the three groups (P>0.05). Conclusion: GnRHa combined with addback therapy can effectively relieve perimenopausal symptoms, improve serum levels of sex hormones, calcium and phosphate, reduce the incidence of adverse reaction, and improve pregnancy rate of women with EMT.

2019 Vol. 27　(9):　1150- [Abstract]（ 441 ） HTML (0 KB)  PDF  (0 KB)  ( 41 )

Objective: To investigate the expression of insulin receptor substrate (IRS) 1, IRS 2 in adipose tissue and serum omenin 1 of women with gestational diabetes mellitus (GDM), and to analyze their correlation with insulin resistance. Methods: 50 pregnant women with GDM were included in the observation group and 50 health pregnant women were selected in the control group. The levels of omentin 1, FINS, FPG of all included women were measured before delivery, and HOMA IR of women were calculated. The adipose tissue of women was collected for detecting the expression of IRS1 and IRS2 during delivery. Results: The levels of FPG and FINS, and value of HOMA IR of women in the observation group were significant higher than those of women in the control group, and the level of omentin 1 was significant lower than that of women in the control group (P<0.05). The levels of IRS 1 and IRS 2 in adipose tissue of women in the observation group were significant lower than those of women in the control group (P<0.05). The value of HOMA IR was negatively correlated with levels of omentin 1, IRS 1 and IRS 2 (P< 0.05), while omentin 1 level was positively correlated with levels of IRS1 and IRS2 (P<0.05). Conclusion: Serum Omentin 1 expression can activate signal transduction pathway back insulin receptor and can increase insulin sensitivity. The decreasing of expressions of serum omentin 1 and IRS 1 and IRS 2 in adipose tissue can further aggravate insulin resistance.

2019 Vol. 27　(9):　1159- [Abstract]（ 455 ） HTML (0 KB)  PDF  (0 KB)  ( 38 )

Objective: To investigate the influence of general anesthesia combined with epidural anesthesia in laparoscopic assisted vaginal hysterectomy of women with uterine benign disease on their hemodynamics and levels of serum tissue type plasminogen activator (tPA), plasminogen activator inhibitor 1 (PAI 1), D dimer (D-D). Methods: From May 2014 to September 2016, 72 women with uterine benign disease were randomly divided into control group and study group (36 cases in each group). The women in the control group were treated by intravenous anesthesia combined with general anesthesia, and the women in the study group received epidural anesthesia combined with general anesthesia. The amount of anesthesia drug for maintaining anesthesia, the recovery situation after anesthesia, the hemodynamic parameters［Heart rate (HR), mean arterial pressure (MAP)］and serum fibrinolytic function index (t PA, PAI 1, D-D) during different time periods before anesthesia (T1), 5 min after anesthesia (T2), immediately after extubation (T3)］, and the adverse reaction rate of women were compared between the two groups. Results: The amount of propofol and vecuronium used for women in the study group during operation was significant less than that for women in the control group (P<0.05). The recovery time, tracheal tube withdrawal time, and time of spontaneous breathing recovery of women in the study group were significant less than those of women in the control group (P<0.05). There were no significant different in HR, MAP and the levels of serum tPA, PAI 1 and D-D of women between the two groups at T1 (P>0.05), but HR, MAP, and the levels of serum tPA, PAI 1 and D-D of women in the study group were significant lower than those of women in the control group at T2 and T3 (P<0.05). The rates of tachycardia, vomiting and nausea, and restless of women in the study group were 13.9%, 16.7%, and 8.3%, respectively, which were significant lower than those (36.1%, 38.9%, and 27.8%, respectively) of women in the control group (P<0.05). Conclusion: The general anesthesia combined with epidural anesthesia used in laparoscopic assisted vaginal hysterectomy of women with uterine benign disease can effectively reduce the amount of anesthesia drugs, can stabilize intraoperative hemodynamic, has less influence on the fibrinolytic function of women, the incidence of adverse reactions is low, and the recovery after anesthesia is quick, so its safety is high.

2019 Vol. 27　(9):　1166- [Abstract]（ 408 ） HTML (0 KB)  PDF  (0 KB)  ( 40 )

Objective: To investigate the changes and significance of lymphocyte to monocyte ratio (LMR), the value of soluble TNF related apoptosis inducing ligand (sTRAIL), inducible nitric oxide synthase (iNOS) level, and CA125 level in benign or malignant ovarian tumors tissue. Methods: From August 2014 to August 2018, 70 patients with malignant tumors (in study group) and 80 patients with benign ovarian tumors (in control group) were selected, and their venous blood samples were collected for detecting blood routine and the levels of CA125, sTRAIL and iNOS, and LMR value was calculated. The differences of sTRAIL and iNOS levels, and LMR value of women with different clinical stages were compared between the two groups. ROC curve was drawn to evaluate the value of above index for differential diagnosing ovarian benign and malignant tumors. Results: The levels of LMR and sTRAIL of women in the study group were significant lower than those of women in the control group, while iNOS and CA125 levels of women in the study group were significant higher. In the study group, the levels of LMR and sTRAIL of women with the stageⅠ-Ⅱ tumor were significant higher than those of women with the stage III-IV tumor, while the levels of iNOS and CA125 were significant lower (P<0.05). The areas under ROC curve (AUC) of levels of LMR, sTRAIL, iNOS, and CA125 for differential diagnosing ovarian tumors were 0.837, 0.788, 0.962 and 0.879, respectively. The sensitivity of ROC of levels of LMR, sTRAIL, iNOS, and CA125 were 67.1%, 71.4%, 85.7% and 82.9%, respectively, and the specificity of levels of LMR, sTRAIL, iNOS, and CA125 were 80.7%, 82.9%, 92.6% and 87.1%, respectively. Conclusion: The levels of inflammation related markers, such as level of LMR, sTRAIL, iNOS and CA125, have some clinical value for differential diagnosing ovarian tumors, and have some clinical significance for predicting the pathological stages of ovarian tumors.

2019 Vol. 27　(9):　1174- [Abstract]（ 437 ） HTML (0 KB)  PDF  (0 KB)  ( 41 )

Objective: To investigate the application of continuous noninvasive instantaneous blood pressure measurement device (WBP) and non invasive blood pressure (NIBP) during cesarean. Methods: 45 women with caesarean section under combined spinal epidural anesthesia were included in this self controlled trial, and all women were measured blood pressure by WBP and NIBP during the operation. The consistency and sensitivity of WBP and NIBP was compared and analyzed. All included women were able to tolerance the blood pressure measurement by WBP and NIBP. 308 pairs of valid matching data were collected for analysis. Results：There were 76 cases with hypotensive event recorded by WBP (24.7%), which was significant higher than that (37 cases, 12.0%) recorded by the NIBP (P<0.05). The difference of systolic or diastolic blood pressure value and the mean arterial pressure bias measured by WBP and NIBP had statistically significant difference (P<0.05). The values of systolic blood pressure, mean arterial pressure, and diastolic blood pressure measured by WBP had better consistency with those measured by NIBP. Pearson correlation analysis showed that the value of blood pressure measured by WBP was correlation with that measured by NIBP. Conclusion: Compared with NIBP, WBP can provide continuous, safe, noninvasive and accurate blood pressure monitoring, which is more suitable for the blood pressure monitoring of women during cesarean under lumbar combined with epidura anesthesia.

2019 Vol. 27　(9):　1180- [Abstract]（ 425 ） HTML (0 KB)  PDF  (0 KB)  ( 36 )

Objective: To explore the value of ultrasound elastography combined with color Doppler ultrasound for diagnosing benign or malignant axillary lymph nodes of patients with breast cancer. Methods: 69 patients with breast cancer were included, and had undergone color Doppler ultrasonography and ultrasound elastography. The value of ultrasound elastography and color Doppler ultrasound for diagnosing benign or malignant axillary lymph nodes of patients with breast cancer was analyzed based on the pathological results as gold standard. There were 28 patients with benign nodules (group A) and 41 patients with malignant nodules (group B) according to the pathologically results. Results: The L/S ratio of axillary lymph node of women in group A was significant higher than that of women in group B (P<0.05). There was no significant different in blood flow resistance index of patients between the two groups (P>0.05). The characteristic of CDFI blood flow of patients in group A was mainly portal type, but that of patients in group B was mainly peripheral type (P<0.05). The axillary lymph node elasticity scores of patients in group A was mainly 1-2 points, which was significantly different from that (3-4 points ) of women in group B (P<0.05). The sensitivity and specificity of color Doppler ultrasound for diagnosing benign or malignant axillary lymph nodes were 67.9% and 63.4%, the sensitivity and specificity of ultrasound elastography for diagnosing benign or malignant axillary lymph nodes were 82.1% and 75.6%, and the sensitivity and specificity of color Doppler ultrasound combined ultrasound elastography for diagnosing benign or malignant axillary lymph nodes were and 92.9% and 97.6%. The area under the curve of color Doppler ultrasound, ultrasound elastography, and color Doppler ultrasound combined ultrasound elastography were 0.719, 0.830, and 0.922, respectively. Conclusion: Ultrasound elastography combined with color Doppler ultrasound can effectively identify the benign or malignant axillary lymph nodes of breast cancer and can determine whether lymph node metastasis occurs, which provides evidence for clinical treating patients with breast cancer.

2019 Vol. 27　(9):　1186- [Abstract]（ 394 ） HTML (0 KB)  PDF  (0 KB)  ( 41 )

Objective: To explore the differences of single port and traditional multiport used in laparoscopic ovarian cystectomy. Methods: The clinical data of 86 patients with ovarian cysts from May 2016 to May 2018 were retrospectively analyzed. According to different surgical methods, the patients were divided into group A (patients treated by single port laparoscopic ovarian cystectomy) and group B (43 patients treated by traditional multiport laparoscopic ovarian cystectomy). The indexes related to surgical, visual analogue scale (VAS) at 24h after operation, the rate of postoperative complication, aesthetic satisfaction degree, and levels of estradiol (E2), luteinizing hormone (LH) and follicle stimulating hormone (FSH) of patients before and after operation were compared between the two groups. Results: There were no significant differences in volume of intraoperative blood loss, operative time, postoperative exhaust time, time of hospital stay, and incidence of postoperative complication of patients between the two groups (P>0.05). The VAS score at 24h after operation of patients in group A was 2.6±1.3 points, which was significant lower than that (5.1±1.8 points) of patients in group B.  The total aesthetic satisfaction of patients in group A was 95.4%, which was significant higher than that (79.1%) of patients in group B (P<0.05). At 1 month after operation, the serum E2 level of patients in the two groups had decreased, while the levels of LH and FSH had increased (P<0.05), and there were no significant differences in the serum E2, LH and FSH levels of patients between the groups (P>0.05). Conclusion: Single port and traditional multiport used in laparoscopic ovarian cystectomy has the same effectiveness and safety, but single port laparoscopic ovarian cystectomy leads less trauma to the body, and can effectively reduce postoperative pain and improve aesthetic satisfaction.

2019 Vol. 27　(9):　1193- [Abstract]（ 341 ） HTML (0 KB)  PDF  (0 KB)  ( 36 )

Objective: To explore the influence of different pregnancy termination timing on maternal and infant outcomes of women with early onset severe preeclampsia. Methods: 64 cases of pregnant women with early onset severe preeclampsia from were included from February 2013 to October 2018, and were divided into group A (20women were terminated pregancy during <32 gestational weeks), group B (23 women were terminated pregancy during 32 to 33+6 gestational weeks), and group C (21 women were terminated pregancy during≥34 gestational weeks). All included women were given personalized treatment planning after evaluated. The clinical situation, mode of delivery, complications during pregnancy and perinatal adverse outcomes of women were compared among the three groups. Result: The gestational weeks when onset severe preeclampsia, the delivery gestational weeks, and duration of expectant treatment of women in Group C were the highest, and those of women in group A were the lowest (P< 0.05). The rate of cesarean section of women in Group A was lowest, but the rate of induced labor by oxytocin was highest (P<0.05). There were no significant different in rates of vaginal delivery and complication during pregnancy among the three groups (P>0.05). The stillbirth rate, neonatal mortality rate, and incidence of fetal respiratory distress syndrome of women in group A were the highest (P<0.05), but there was no difference in the perinatal asphyxia rate among the three groups (P>0.05). Conclusion: Terminating pregnancy of women with early onset severe preeclampsia at different timing can impact on maternal and infant outcomes. Expectant treatment can be conducted in women with early onset severe preeclampsia when their disease is stable. If the complications are serious, timely terminating pregnancy should be considered to improve maternal and infant outcomes.

2019 Vol. 27　(9):　1201- [Abstract]（ 364 ） HTML (0 KB)  PDF  (0 KB)  ( 38 )

Objective: To investigate the levels and significance of levels of serum anti thyroglobulin antibody (TGAb), anti thyroid peroxidase antibody (TPOAb), thyrotropin (TSH), free triiodothyronine (FT3), free thyroxine (FT4), triiodothyronine (T3) and thyroxine (T4) of women with gestational diabetes mellitus(GDM). Methods: 200 pregnant women with GDM were selected in GDM group and 200 healthy pregnant women were selected in control group from March 2015 to June 2018. The levels of TGAb, TPOAb, TSH, FT3, T3, T4, and FT4 of all included women were measured before delivery. Results: There were no significant difference in levels of TSH, T3, T4 and FT3 of women between the two group (p>0.05). The FT4 level of women in GDM group was (5.01±1.01) pmol/L, which was significant lower than that of women in the control group (P<0.05). The positive rates of TGAb, TPOAb, TGAb+TPOAb of women in GDM group   were 14.0%, 10.5% and 9.0%, respectively, which were significant higher than those of women in the control group (P<0.05). In GDM group, there were no significant difference in levels of serum TSH, T3, T4, FT3 and FT4 between women with adverse pregnancy outcomes and women with normal pregnancy outcomes (P<0.05), and the positive rates of TGAb, TPOAb, TGAb+TPOAb of women with adverse pregnancy outcomes were 23.1%, 16.9% and 16.9%, respectively, which were significant higher than those of women with normal pregnancy outcomes (P<0.05). Conclusion: The levels of serum TGAb, TPOAb and FT4 of pregnant women with GDM are abnormal, which maybe have some adverse influence on pregnancy outcomes.

2019 Vol. 27　(9):　1208- [Abstract]（ 376 ） HTML (0 KB)  PDF  (0 KB)  ( 39 )

Objective: To explore the value of serum micro RNA 181b (miR 181b) and micro RNA 210 (miR 210) levels for diagnosing women with hypertensive disorder complicating pregnancy. Methods: The blood samples from 96 women with hypertensive disorder complicating pregnancy (in study group) and 96 healthy pregnant women (in control group) were collected. Real time fluorescence quantitative PCR (qRT PCR) was used to detect the expression of miR 181b and miR 210. The relationship between the levels of miR 181b and miR 210 and clinical indicators were observed and analyzed. Receiver operating characteristic (ROC) curve was used to evaluate the optimal threshold value of miR 181b or miR 210 for diagnosing hypertensive disorder complicating pregnancy and for evaluating their diagnosis efficiency. Results: The levels of serum miR 181b and miR 210 of women in the study group were significant higher than those of women in the control group (P<0.05). In the study group, the level of serum miR 181b or miR 210 was positively correlated with the levels of serum homocysteine (Hcy), C reactive protein (CRP), and malondialdehyde (MDA) (P<0.05), was negatively correlated with total antioxidant capacity (TAC) and superoxide dismutase (SOD) (P<0.05), but was no correlated with glutathione peroxidase (GSH Px) (P>0.05). ROC curve analysis showed that the cut off value, the sensitivity, and the specificity of miR 181b level were 1.50, 57.3%, and 76.0%, respectively. And the cut off value, the sensitivity and the specificity of miR 210 level was 1.10, 55.2%, and 75.3%, respectively. The accuracy, the sensitivity, and the specificity of miR 181b level combined with miR 210 level were 83.3%, 88.5%, and 85.9%, respectively, which were significant higher than those of miR 181b level or miR 210 level only (P<0.05). Conclusion: The levels of serum miR 181b and miR 210 of women with hypertensive disorder complicating pregnancy increase, and the miR 181b level combined with the miR 210 level can improve the diagnosis efficiency of hypertensive disorder complicating pregnancy.

2019 Vol. 27　(9):　1217- [Abstract]（ 381 ） HTML (0 KB)  PDF  (0 KB)  ( 47 )

Objective: To observe the value of colposcopy biopsy combined with P16 and OLFM4 for diagnosing women with cervical intraepithelial neoplasia (CIN). Methods: From April 2017 to April 2019, 240 patients with CIN who underwent colposcopy biopsy were selected into study group, which included 98 cases with CIN I, 82 cases with CIN II and 60 cases with CIN III based on the pathological diagnostic results. Another 60 patients with cervical benign lesion were selected into control group. The results of colposcopy biopsy of all patients were observed. The expressions of P16 and OLFM4 were detected by immunohistochemistry. Results: The coincidence rates of CIN I, CIN II and CIN III diagnosis by colposcopy biopsy were 91.7%, 90.2%, and 96.7%. The positive expression rates of P16 and OLFM4 of women in the control group were significant lower than those of women in the control group (P<0.05). The positive expression of P16 and OLFM4 was the lowest in the patients with CIN I and was the highest in the patients with CIN III (P<0.05). Conclusion: Colposcopy biopsy combined with the expression of P16 and OLFM4 can increase the detection rate of CIN. Excessive expressions of P16 and OLFM4 are closely related to the occurrence, development and prognosis of CIN.

2019 Vol. 27　(9):　1225- [Abstract]（ 348 ） HTML (0 KB)  PDF  (0 KB)  ( 46 )

Objective: To investigate the quality of life of women with dysmenorrhea because of adenomyosis, and to study its influencing factors. Methods: 126 women with dysmenorrhea because of adenomyosis were selected in observation group, and 120 healthy women were selected into control group during the same period from March 2016 to February 2018. The quality of life of women with dysmenorrhea because of adenomyosis and its influencing factors were studied. Results: The total score of quality of life of women by SF-36 scale in observation group was significant lower than that of women in the control group (P<0.05). The dysmenorrhea scores of women in the observation group was 63.1±5.8points, which had no significant difference from that (62.8±5.6) of women in the control group (P>0.05). While the VAS score of women in the observation group was 58.6±4.7points, which was significant higher than that (50.2±4.8 points) of women in the control group (P<0.01). Logistic analysis showed that the lower abdominal pain, pain during intercourse, anal pain, urinate frequency in the night were independent risk factors affecting dysmenorrheal because of adenomyosis. Conclusion: The quality of life of women with dysmenorrhea because of adenomyosis decreases, so the clinical intervention should be paid attention to for improving their quality of life.

2019 Vol. 27　(9):　1233- [Abstract]（ 352 ） HTML (0 KB)  PDF  (0 KB)  ( 39 )

Objective: To analyze the improving effect of pelvic floor function rehabilitation on pelvic floor function and vaginal relaxation of parturients. Methods: The clinical data of 100 parturients with vaginal relaxation on the 42th day after delivery were collected from January 2018 to December 2018, which included the control group (parturients were given routine treatment) and the observation group (parturients were given pelvic floor rehabilitation). The clinical efficacy of parturients was compared between the two groups. Results: After treatment, the levels of TGFβ1, IGF1 of parturients in the observation group was significant higher than those of parturients in the control group, and the level of endothelin 1 (ET 1) was significant lower than that of parturients in the control group(P<0.05). The pelvic floor muscle function of parturients in the observation group was significant higher than that of parturients in the control group (P<0.05), which included there were 8 parturients with grade I pelvic floor function, 18 parturients with grade II+III pelvic floor function, 24 parturients with grade IV or V pelvic floor function in the observation group, and there were 18 parturients with grade I pelvic floor function, 20 parturients with grade II+III pelvic floor function, and 11 parturients with grade IV+V pelvic floor function in the control group. There was significant difference in the vaginal relaxation degree of parturients between the two groups (P<0.05), which included 19 parturients with mild vaginal relaxation, 20 parturients with moderate vaginal relaxation, 11 arturients with severe vaginal relaxation in the observation group, and 10 arturients with mild vaginal relaxation, 18 cases of arturients with moderate vaginal relaxation and 22 arturients with severe vaginal relaxation in the control group. With in 6 and 12 months after treatment, the scores of pelvic floor dysfunction (PED I20) of arturients in the observation group were 5.1±1.4 points and 4.3±1.2 points, which were significant lower than those (9.2±4.0 points and 8.9±3.2 points) of arturients in the control group (P<0.05). The total satisfaction of arturients in the observation group was 94.0%, which was significant higher than that (72.0%) of arturients in the control group (P<0.05). Conclusion: Pelvic floor rehabilitation can increase the levels of TGFβ1 and IGF1, reduce the level of ET1, can effectively promote the recovery of pelvic floor muscle strength, alleviate vaginal relaxation and improve the satisfaction of arturients.

2019 Vol. 27　(9):　1239- [Abstract]（ 345 ） HTML (0 KB)  PDF  (0 KB)  ( 32 )

Objective: To discussion the intraoperative conditions during 3 kinds of medicated intrauterine device (IUD) inserted, and to analysis their efficacy and safety. Methods: 353 women in childbearing age who wanted contraception by IUD were selected and divided into group A (126 cases inserted MYCu), group B (105 cases inserted GyneFix), and group C (200 cases inserted Yuangong200). The situations of operation of IUD inserted and the followed up within two years after operation were observed. Results: The rate of success inserted of women in group A or B were 98.1% or 100%，which was significant higher than that (79.5%) of women in group C (P<0.05).The removal rate for medical reasons of women in group C, A and B were 11.1%, 9.8% and 1.0 %, which had significant difference among the three groups (P<0.05). The total discontinuation rate women in group C, A and B re were 17.5%, 16.4% and 2.9%, which had statistical significance difference among the three groups (P<0.05). The incidence of side effect of women within 24 months after IUD inserted in group B was the lowest, but that of women in group A was the highest. Conclusion: GyneFix IUD is easy to insert and has less side effects, its removal rate for medical reasons is low and has high continuation rate.

2019 Vol. 27　(9):　1245- [Abstract]（ 438 ） HTML (0 KB)  PDF  (0 KB)  ( 34 )