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| Curative efficacy of Fugongning granule combined with medroxyprogesterone acetate for treating women with endometriosis and its effects on levels of serum FS, sICAM1 and sIL2R |
| Qingdao Municipal Hospital, Shandong Province, 266011 |
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Abstract Objective: To explore the curative efficacy of Fugongning granule combined with medroxyprogesterone acetate for treating women with endometriosis, and to study its effects on levels of serum follicostatin (FS), soluble intercellular adhesion molecule (sICAM1) and soluble leukocyte 2 receptor (sIL2R). Methods: 124 women with endometriosis were selected as research objects and were divided into group A and group B by random number table from February 2015 to February 2018. 61 women in group A were treated by progesterone for 3 months, and 63 women in group B were treated by Fugongning granule combined with medroxyprogesterone acetate for 3 months. The clinical efficacy, the changes of hormones index, TCM syndrome score and adverse reaction rate were compared between the two groups. Results: The total effective rate and the estradiol (E2) level of women in group B were 93.7% and 587.56±39.50pg/ml, which were significant higher than those (80.3% and 514.91±34.85pg/ml) of women in group A, but the serum levels of follicular estrogen (FSH), luteinizing hormone (LH), FS, sICAM1, sIL2R and TCM syndrome scores of women in group B were 4.92±0.58U/L, 7.12±1.08U/L, 237.31±20.08ng/L, 271.28±16.74ng/ml, 245.82±18.54ng/ml, and 3.9±0.8 scores, respectively, which were significant lower than those (7.69±0.73U/L, 9.05±1.24U/L, 324.48±25.61ng/L, 304.53±18.39ng/ml, 288.39±20.91ng/ml, and 5.4±0.9 scores, respectively) of women in group A (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (4.8% VS. 3.3%, P>0.05). Conclusion: Fugongning granule combined with medroxyprogesterone acetate for treating women with endometriosis has good efficacy, which can effectively reduce the expression of serum FS, sICAM1 and sIL2R levels and can promote the recovery of disease.
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