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Abstract Objective: To investigate the relationship between the serum apolipoprotein A5 (ApoA5) level and glycolipid metabolism of women with gestational diabetes mellitus (GDM). Methods: 90 pregnant women with GDM were selected in observation group from October 2016 to October 2017, and 60 healthy pregnant women were selected in control group during the same period. The levels of serum FBG, HbA1c, FINS, TC, TG, HDL C, LDL C and ApoA5, and HOMA IR value of all included women were observed and were statistically analyzed. Results: The levels of TG, TC, FBG, FINS, HbA1c, ApoA5, and HOMA IR value of women in the observation group were significant higher than those of women in the control group, but the levels of HDL C of women in the observation group was significant lower (P<0.05). In the study group, Pearson correlation analysis showed that serum ApoA5 level was positively correlated with the levels of TG, TC, FBG, and value of HOMA IR value (r=0.491, 0.324, 0.483, 0.518, P<0.05), the serum ApoA5 level was negatively correlated with level of HDL C (r=0.313, P<0.05), but the serum ApoA5 level was no correlated with levels of HbA1c, FINS, and LDL C (P>0.05). Logistic multivariate regression analysis showed that levels of serum ApoA5, TG, TC, FBG and value of HOMA IR were all risk factors for the occurrence and development of GDM (P<0.05). Conclusion: The abnormal level of serum ApoA5 of pregnant women with GDM is closely related to the occurrence and development of GDM and abnormal glycolipid metabolism, so it can provide evidence for diagnosing and treating GDM.
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