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Abstract Objective: To investigate the changes and significance of lymphocyte to monocyte ratio (LMR), the value of soluble TNF related apoptosis inducing ligand (sTRAIL), inducible nitric oxide synthase (iNOS) level, and CA125 level in benign or malignant ovarian tumors tissue. Methods: From August 2014 to August 2018, 70 patients with malignant tumors (in study group) and 80 patients with benign ovarian tumors (in control group) were selected, and their venous blood samples were collected for detecting blood routine and the levels of CA125, sTRAIL and iNOS, and LMR value was calculated. The differences of sTRAIL and iNOS levels, and LMR value of women with different clinical stages were compared between the two groups. ROC curve was drawn to evaluate the value of above index for differential diagnosing ovarian benign and malignant tumors. Results: The levels of LMR and sTRAIL of women in the study group were significant lower than those of women in the control group, while iNOS and CA125 levels of women in the study group were significant higher. In the study group, the levels of LMR and sTRAIL of women with the stageⅠ-Ⅱ tumor were significant higher than those of women with the stage III-IV tumor, while the levels of iNOS and CA125 were significant lower (P<0.05). The areas under ROC curve (AUC) of levels of LMR, sTRAIL, iNOS, and CA125 for differential diagnosing ovarian tumors were 0.837, 0.788, 0.962 and 0.879, respectively. The sensitivity of ROC of levels of LMR, sTRAIL, iNOS, and CA125 were 67.1%, 71.4%, 85.7% and 82.9%, respectively, and the specificity of levels of LMR, sTRAIL, iNOS, and CA125 were 80.7%, 82.9%, 92.6% and 87.1%, respectively. Conclusion: The levels of inflammation related markers, such as level of LMR, sTRAIL, iNOS and CA125, have some clinical value for differential diagnosing ovarian tumors, and have some clinical significance for predicting the pathological stages of ovarian tumors.
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