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| The expression and significance of serum levels of HSP 70, GATA 3 and sflt 1 of women with gestational hypertension |
| The Ninth Hospital of Wuhan, Hubei Province, 430081 |
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Abstract Objective: To explore the expression and significance of serum levels of Heat shock protein 70 (HSP 70), cell transcription factor 3 (GATA 3), soluble vascular endothelial growth factor receptor 1 (sflt 1) of women with gestational hypertension. Methods: 80 women with gestational hypertension were selected in the observation group from February 2016 to February 2017, and 60 normal pregnant women were selected in control group. The levels of serum HSP 70, GATA 3 and sflt 1 of all women were analyzed. Results: The levels of serum HSP 70 and sflt 1 of women in the observation group were significant higher than those of women in the control group, but the GATA 3 level of women in the observation group was significant lower. In the observation group, the levels of HSP70 and sflt 1 of women without preeclampsia were significant lower than those of women with mild preeclampsia or severe preeclampsia, but the GATA 3 level of women without preeclampsia was significant higher (P<0.05). Correlation analysis showed that levels of HSP 70 and sflt 1 were positively correlated with the rate of women with gestational hypertension, mild preeclampsia, or severe preeclampsia, while GATA 3 level was negatively correlated with the rate of women with gestational hypertension, mild preeclampsia, or severe preeclampsia gestational hypertension, mild preeclampsia and severe preeclampsia (P<0.05). Conclusion: The expression of HSP70, GATA 3 and sflt 1 of pregnant women with gestational hypertension is closely related to the severity of the disease, which maybe provide a new idea for targeted drug treatment of gestational hypertension.
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