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| A Meta analysis of granulocyte stimulating factor for treating patients with unexplained recurrent abortion |
| 1.Chengdu University of Traditional Chinese Medicine, Sichuang Province, 611130;2.Chengdu Fifth People’s Hospital |
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Abstract Objective: To analyze the efficacy of granulocyte stimulating factor for treating patients with unexplained recurrent abortion by Meta analysis. Methods: The database, such as Pubmed, Embase, Ovid, Medline, Cochrane, wanfang full-text database, cnki, China biomedical literature database, vip medicine and other literature databases, were electronic researched until April 2019, and supplemented articles were manual searched from magazines. According to the Cochrane systematic evaluation method, the data of related granulocyte stimulating factor for treating patients with unexplained recurrent abortion from randomized controlled trials (RCTs) were collected and extracted by two researchers. Results: A total of 5 RCTs were included, which included 536 patients. Granulocyte colony stimulating factor used during ovulation for treating patients with unexplained recurrent abortion decreased the abortion rate (RR 0.4，95% CI0.26-0.61) and increased the live birth rate (RR 1.35，95% CI 1.11-1.65). However, granulocyte colony stimulating factor used didn’t significantly effect on the live birth rate (RR 0.91，95% CI 0.71-1.17) and abortion rate (RR 1.09，95% CI 0.71-1.68), also did not significantly change the neonatal weight (MD -7.18，95% CI -143.62-129.27), did not increased risk of pregnancy complications (RR 0.30，95% CI 0.05-1.93), and did not increased the rates of side effects of drug, such as skin rash (RR 2.65，95% CI 0.53-13.09), but leukocytosis of patients had increased after granulocyte colony stimulating factor treatment (RR19.86, 95% CI 3.76-104.78). Conclusion: The use of granulocyte colony stimulating factor during ovulation can improve the rate of live birth and reduce the rate of abortion of patients with unexplained recurrent abortion.
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