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| The relationship between the levels of thyroid function indicators of women with gestational diabetes mellitus and their pregnancy outcomes |
| Shanghai Jiading Maternal and Child Health Care Hospital, Shanghai, 201800 |
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Abstract Objective: To investigate the levels and significance of levels of serum anti thyroglobulin antibody (TGAb), anti thyroid peroxidase antibody (TPOAb), thyrotropin (TSH), free triiodothyronine (FT3), free thyroxine (FT4), triiodothyronine (T3) and thyroxine (T4) of women with gestational diabetes mellitus(GDM). Methods: 200 pregnant women with GDM were selected in GDM group and 200 healthy pregnant women were selected in control group from March 2015 to June 2018. The levels of TGAb, TPOAb, TSH, FT3, T3, T4, and FT4 of all included women were measured before delivery. Results: There were no significant difference in levels of TSH, T3, T4 and FT3 of women between the two group (p>0.05). The FT4 level of women in GDM group was (5.01±1.01) pmol/L, which was significant lower than that of women in the control group (P<0.05). The positive rates of TGAb, TPOAb, TGAb+TPOAb of women in GDM group were 14.0%, 10.5% and 9.0%, respectively, which were significant higher than those of women in the control group (P<0.05). In GDM group, there were no significant difference in levels of serum TSH, T3, T4, FT3 and FT4 between women with adverse pregnancy outcomes and women with normal pregnancy outcomes (P<0.05), and the positive rates of TGAb, TPOAb, TGAb+TPOAb of women with adverse pregnancy outcomes were 23.1%, 16.9% and 16.9%, respectively, which were significant higher than those of women with normal pregnancy outcomes (P<0.05). Conclusion: The levels of serum TGAb, TPOAb and FT4 of pregnant women with GDM are abnormal, which maybe have some adverse influence on pregnancy outcomes.
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