Objective: To explore the effect of circRNA Amotl-1 on pregnant women with gestational diabetes mellitus (GDM) and preterm delivery, and to investigate the relationship between circRNA Amotl-1 and endothelial colony-forming cells. Methods: 60 pregnant women with GDM and preterm delivery were included in study group, and the 10 health pregnant women were included in control group. The endothelial colony-forming cells of women in both groups were collected. The relationship between circRNA Amotl-1 and and endothelial colony-forming cells was observed by scratch test and tubule formation test. Results: The rate of endothelial clonogenic cells of women in the study group was 99.2%, which was signifficant higher than that (35.7%) of women in the control group. In the tubule form experiment, the length of tubule of cell after si RNA transfection was 105.17±1.34m, and that after plasmid transfection was 151.62±2.51m, which were all significant more than that (98.56±3.71m) of cell with blank control (P<0.05). In the cell scratch plane migration experiment, the migration rate of circRNA Amotl-1 plasmid was nearly 100%, that of si RNA was 55.9%, and that in the control group was 5.2%. Conclusion: circRNA Amotl-1 can regulate the occurrence and development of the preterm delivery of pregnant women with GDM by promoting endothelial colony-forming cells.

2020 Vol. 28　(2):　156- [Abstract]（ 439 ） HTML (0 KB)  PDF  (0 KB)  ( 39 )

Objective: To discuss the causes of abortion of women during the second trimester of pregnancy, and to provide evidence of PAC for these women. Methods: A questionnaire by self-designed was used to investigate 470 women who were hospitalized for termination of pregnancy from March 1, 2015 to March 1, 2016. Results: The results of regression analysis showed that unmarried/divorced (OR=2.111, 95% CI 1.260-3.536), under junior high school education level (OR=2.408, 95% CI 1.055-5.500), untimely pregnancy confirmation (OR=3.442, 95% CI 1.861-6.369), untimely decision to terminate pregnancy (OR=3.777, 95% CI 2.144-6.654), fetal malformation OR genetic disease (OR=14.056, 95% CI 3.778-52.297), family factors (OR=5.962, 95% CI 2.631-13.509) were the risk factors for terminating pregnancy of women during the second trimester of pregnancy. Conclusion: Unmarried, divorce, low educated level and low income level of women are the high-risk women with abortion during the second trimester of pregnancy. It is necessary to strengthen the contraceptive education for women to avoid their abortion during the second trimester of pregnancy.

2020 Vol. 28　(2):　162- [Abstract]（ 301 ） HTML (0 KB)  PDF  (0 KB)  ( 39 )

Objective: To explore the curative efficacy of Sini decoction huacai combined with medroxyprogesterone acetate for treating women with endometriosis, and to study its effect on inflammatory factors and intimal blood supply of women. Methods: 75 women with endometriosis who had been diagnosed to cold coagulation and blood stasis syndrome by TCM Dialectics were selected and were divided into the study group (40 women treated with medroxyprogesterone acetate combined with Sini decoction huacai for 12 weeks) and control group (35 women treated with medroxyprogesterone acetate for 12 weeks) from January 2018 to December 2018. The clinical efficacy, TCM symptom score, serum inflammatory factors, such as tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) and IL-8, and endometrial receptivity, such as uterine artery pulsation index (PI) and resistance index (RI), and adverse reaction rate of women were compared between the two groups. Results: After treatment, the total effective rate of women in the study group was 92.5%, which was significant higher than that (74.3%) of women in the control group (P<0.05). The TCM symptom score, the levels of serum TNF-, IL-6 and IL-8, the values of uterine artery PI and RI of women in the study group were 4.3±0.4 scores, 61.0±7.2ng/L, 35.4±3.8 ng/L, 82.3±9.4ng/L, and 1.0±0.2 and 0.4±0.1, respectively, which were significant lower than those (6.2±0.6 scores, 78.54±9.3ng/L, 47.0±4.6ng/L, 103.4±10.7ng/L, and 1.33±0.2, and 0.6±0.1, respectively) of women in the control group (P<0.05). The total incidence of adverse reactions of women in the study group was 8.6%, which had no significant different to that (5.0%) of women in the control group (P>0.05). Conclusion: Sini decoction huacai combined with medroxyprogesterone acetate for treating women with endometriosis because of cold coagulation and blood stasis syndrome has good efficacy, which can effectively improve inflammation situation of women, can increase their intimal blood supply, and can promote the recovery of disease.

2020 Vol. 28　(2):　168- [Abstract]（ 435 ） HTML (0 KB)  PDF  (0 KB)  ( 39 )

Objective: To explore the effect of different courses of metformin combined with clomiphene citrate (CC) for ovulation induction of women with polycystic ovary syndrome (PCOS). Methods: Women with PCOS were selected as subjects, and were randomly devided in group A, B, and C from January 2016 to December 2017. 34 women in group A were treated by metformin combined with CC for 12 weeks (long course), 35 women in group B were treated by metformin combined with CC for 4 weeks (short course), and 34 women in group C were treated by metformin combined with CC for 14d (ultra-short course). After six menstrual cycles followed up, the follicular development, endometrial development, cervical mucus score, and sex hormones levels of women in the three groups were observed, and the pregnancy outcomes of all women were calculated. Results: The number of mature follicles, cervical mucus score, and the endometrium thickness of women in group A and B were significant higher than those of women in group C (P<0.05). The ovulation rate (91.2%) of women in group A was highest, and the pregnancy rate (54.3%) of women in group C was highest. There were no statistical significant different in levels of serum and follicular E2, and the rate of third line markers of endometrium morphology by ultrasound of women among the three groups (P>0.05). Conclusion: The short course of metformin combined with CC can effectively promote the ovulation induction effect of PCOS women with insulin resistance and CC resistance, and can shorten the treatment period, which can be application in clinical practice.

2020 Vol. 28　(2):　176- [Abstract]（ 375 ） HTML (0 KB)  PDF  (0 KB)  ( 44 )

Objective: To investigate the change and significances of levels of serum complement-Clq TNF-related protein-3 (CTRP3), chemerin, and Apelin of infertility women with polycystic ovary syndrome (PCOS). Methods: From August 2017 to August 2018, 60 infertility women with PCOS were selected in study group, and 60 infertility women without PCOS were selected in control group. The levels of serum CTRP3, chemerin, and Apelin of women in both groups were measured and their clinical significances were analyzed. Results: The serum CTRP3 level of women in the study group was significant lower than that of women in the control group, but the levels of serum chemerin and Apelin of women in the study group were significant higher (P<0.05). The value of body mass index (BMI), and the levels of C-reactive protein (CRP), low density lipoprotein cholesterol (LDL), and insulin resistance index (HOMA-IR) of women in the study group were significant higher than those of women in the control group, but the level of serum high density lipoprotein cholesterol (HDL) of women in the study group were significant lower (P<0.05). The serum CTRP3 level was negatively correlated with the BMI value, and the levels of CRP, LDL, and HOMA-IR (P<0.05), but that was positively correlated with HDL level (P<0.05). The serum CTRP3 level was negatively correlated with the chemerin and Apelin levels (P=0.000), and the serum chemerin level was positively correlated with the Apelin level (P=0.000). In the study group, the AUC by ROC curve analysis, the sensitivity, and the specificity of serum CTRP3 level were 0.769, 68.3%, and 71.7%, respectively. The AUC, the sensitivity, and the specificity of serum chemerin level were 0.772, 68.33%, and 80.0%, respectively. And the AUC, the sensitivity, and the specificity of serum Apelin level were 0.831, 78.3%, and 85.0%, respectively. Conclusion: The serum CTRP3 level of infertility women with PCOS has decreased, but their levels of Chemerin and Apelin have increased, which is related to obesity, lipid metabolism disorder, and inflammation of women. The serum CTRP3 level is negatively correlated with the levels of chemerin and Apelin, while the chemerin level is positively correlated with Apelin level. And the changes of the levels of serum CTRP3, chemerin, and Apelin have some clinical significance for diagnosing infertility women with PCOS.

2020 Vol. 28　(2):　184- [Abstract]（ 372 ） HTML (0 KB)  PDF  (0 KB)  ( 33 )

Objective: To investigate the influence of medical nutrition therapy (MNT) combined with metformin on chronic non-specific inflammatory status in obese women with polycystic ovary syndrome (PCOS) and insulin resistance (IR). Methods: 90 obese women with PCOS and IR were randomly divided into observation group and control group (45 cases in each group). Except to conventional therapy on PCOS, the women in the control group received metformin treatment for 3 menstrual cycles, and the women in the observation group received MNT combined with metformin treatment for 3 menstrual cycles. The body mass index (BMI), waisttohip ratio (WHR), serum levels of sex hormones, glucose and lipid metabolism indicators, inflammation indexes of women before and after treatment were compared between the two groups. Results: After treatment, the values of BMI and WHR, and the levels of serum T, LH, LH/FSH, FINS, HOMAIR, TC, TG, LDL-C, CRP, TNF-α, IL-6, IL-17, Visfatin, and Chemerin of women in the observation group were significant lower than those of women in the control group, while the HDL-C of women in the observation group was significant higher (P<0.05). Conclusion: MNT combined with metformin for treating obese women with PCOS can reduce their values of BMI and WHR, can alleviate their chronic non-specific inflammatory state, and can improve their endocrine metabolism and reproductive function.

2020 Vol. 28　(2):　193- [Abstract]（ 365 ） HTML (0 KB)  PDF  (0 KB)  ( 42 )

Objective: To analyze the effect of diffrent type of NIPT platforms for detection of fetal microdeletion and microduplication, and to explore the causes of difference of these NIPT screening platforms. Methods: A retrospective analysis was performed, in which, 23,170 peripheral blood samples of pregnant women were used to screen fetal chromosome microdeletion and microduplication based on three types of NIPT screening platforms from January to October 2018. Results: The screening positive rate of fetal chromosome microdeletion and microduplication based on the DA8600 platform, the CN500 platform, and the BGI500 platform were 0.38%, 0.26%, and 0.58%, respectively, which had significant different (P<0.05). The positive predictive value of screen fetal chromosome microdeletion and microduplication based on the DA8600 platform, the CN500 platform, and the BGI500 platform were 26.67%, 16.67%, and 42.86%, which had no significant different (P>0.05). The process parameters of the BGI500 platform was 6.61±1.19M, which was significant higher than that of the DA8600 or CN500 platforms. Conclusion: The NIPT for screening fetal CNV has certain clinical predictive value, which combined with unique read number can improve the efficiency of fetal chromosome microdeletion and microduplication detection. It is suggested that screening positive samples with fetal chromosome microdeletion or microduplication, especially for samples with pathogenicital chromosome microdeletion or microduplication, prenatal diagnosis by amniocentesis for identify is necessary.

2020 Vol. 28　(2):　203- [Abstract]（ 400 ） HTML (0 KB)  PDF  (0 KB)  ( 35 )

Objective: To analyze the relationship between the weight gain of women in different gestational weeks and their gestational diabetes mellitus (GDM) occurance. Methods: 752 pregnant women were enrolled in this prospective cohort study from January 2015 to January 2018. The women's weight before pregnancy, and during the first, second and third trimester of pregnancy was recorded. The weight gain of all women in different gestational weeks was calculated. The GDM incidence of women during different gestational weeks was compared among group A (women with insufficient weight gain), group B (women with normal weight gain), and group C (women with excessive weight gain). Logistic regression analysis was used to explore the relationship between gestational weight gain of women and GDM occurance. Results: In the 752 pregnant women, 131 (17.4%) women with GDM were detected. During the first trimester of pregnancy, the GDM incidence of women in group C was significant higher than that of women in group A or group B (P<0.05). During pregnancy, the GDM incidence of women in group A was the highest, but the GDM incidence of women in group C was the lowest (P<0.05). Based on normal weight gain during pregnancy as the reference category of independent variables, Logistic regression analysis showed that after adjusting the confounding factors, the risk of GDM occurance of women with excessive weight gain during the first trimester of pregnancy was 2.21, the risk of GDM occurance of women with excessive weight gain during the third trimester of pregnancy was 0.52, and the risk of GDM occurance of women with insufficient weight gain during pregnancy was 2.17 (P<0.05). Conclusion: Excessive weight gain of women during the third trimester of pregnancy and insufficient weight gain of women during pregnancy can increase the risk of GDM occurance. However, the risk of GDM occurance of women with excessive weight gain during the third trimester of pregnancy decreases, which specific mechanism needs to be further explored.

2020 Vol. 28　(2):　213- [Abstract]（ 406 ） HTML (0 KB)  PDF  (0 KB)  ( 37 )

Objective: To explore the relationships between levels of serum 25-Hydroxyvitamin D3(25（OH）D3) and homocysteine, and abnormal electrocardiogram (ECG) of elderly pregnant women during the third trimester pregnancy and their pregnancy outcomes. Methods: 280 pregnant women during 28-41 gestational weeks were selected and were divided in study group (140 women aged over 35 years old), and in control group (140 women aged 20-34 years old )from January 2016 to December 2017. The level of serum 25（OH）D3 of pregnant women was detected by electrochemiluminescence, the level of serum homocysteine (Hcy) of pregnant women was detected by ELISA, and the electrocardiogram of all included women was recorded by electrocardiograph. The pregnancy outcomes of women in both groups were followed up. The 25（OH）D3 and Hcy levels of women were compared between the two groups, and the relationships between the 25（OH）D3 and Hcy levels, and abnormal ECG rate of women and their pregnancy outcomes were analyzed. Results: The level of serum 25（OH）D3 of women in the study group was significant lower than that of women in the control group, but the level of Hcy of women in the study group was significant higher (P<0.05). In the study group, the level of 25（OH）D3 of women with abnormal ECG or with adverse pregnancy outcomes was significant lower, and the level of Hcy of women with abnormal ECG was significant higher (P<0.05). In the study group, the rat of abnormal ECG of women with adverse pregnancy outcomes was significant higher than that of women with good pregnancy outcomes (P<0.05). Logistic regression analysis showed that the levels of  25（OH）D3 and Hcy, and abnormal electrocardiogram were independent risk factors of adverse pregnancy outcomes of elderly pregnant women (P<0.05). Conclusion: Elderly pregnant women in the third trimester pregnancy has lower serum 25（OH）D3 level and higher Hcy level, they are easy to have abnormal ECG, so it is should be regularly detecting the levels of  25（OH）D3 and Hcy of elderly pregnant women, and monitoring their ECG.

2020 Vol. 28　(2):　219- [Abstract]（ 445 ） HTML (0 KB)  PDF  (0 KB)  ( 47 )

Objective: To explore the influence of vaginal microbes on group B streptococcus (GBS) infection of pregnant women during the third trimester of pregnancy. Methods: 80 pregnant women during the third trimester of pregnancy were selected as research objects from August 2014 to May 2018, and their vaginal secretions were collected for detecting B streptococcal infection. 24 women with positive B streptococcal infection were in study group A, and 56 women with negative B streptococcal infection were in control group. The influence of vaginal microbes of women in both groups on their vaginal GBS infection was studied. Results: The abnormal vaginal PH rate of women in the study group was 91.7%, which was significant higher than that of women in the control group. The rates of fungus positive and bacterial vaginosis positive of women in the study group were 25.0% and 33.3%, which were significant higher than those (4.0% and 7.8%) of women in the control group (P<0.05). There was no significant different in trichomonas positive rate of women between the two groups (P>0.05). The positive rates of hydrogen peroxide (H2O2), leucocyte esterase (LE), sialidase (SnaSe), proline aminopeptidase (PIP), acetylaminoglucosidase (NAG) of women in the study group were significant higher than those of women in the control group (P<0.05 ). Conclusion: The vaginal microbes of pregnant women during the third trimester of pregnancy have some influence on their GBS infection, so the detection of vaginal microflora should be paid more attention to.

2020 Vol. 28　(2):　226- [Abstract]（ 337 ） HTML (0 KB)  PDF  (0 KB)  ( 39 )

Objective: To investigate the expression of long non-coding RNA (LncRNA) nuclear enrichment transcript 1 (NEAT1), and HOX transcriptional antisense RNA (HOTAIR) in exfoliated cells of patients with cervical persistent high-risk human papillomavirus (HPV) infection, and to explore their clinical significances. Methods: 56 patients with cervical HPV infection were selected from August 2017 to August 2018, and their exfoliated cervical cells were collected for liquid-based thinprep cytologic test (TCT) and HPV DNA genotyping detection. According to the results of HPV detection, the patients were divided into group A (patients with cervical persistent HPV infection) and group B (patients with cervical HPV infection disappeared). The positive expressions of p16 and Ki67 were detected by immunohistochemistry, the expression levels of LncRNA NEAT1 and HOTAIR were detected by qRT-PCR. Spearman analysis was used for abalyze the correlations, and ROC was used for study the diagnostic values. Results: 14 high-risk subtypes HPV and 5 low-risk subtypes were found in 56 samples by conduction hybridization method. The relative expression levels of LncRNA NEAT1 and HOTAIR detected by qRT-PCR in group A were significant higher than those in group B, and the positive expressions of p16 and Ki67 detected by immunohistochemistry in group A were also significant higher than those in group B (P<0.05). LncRNA NEAT1 level was positively correlated with p16 and Ki67 levels (P=0.033, 0.027), and HOTAIR level was also positively correlated with p16 and Ki67 levels (P=0.021, 0.013). The AUC areas, the specificity, and the sensitivity of LncRNA NEAT1 level for diagnosing cervical persistent HPV infection were 0.838, 95.65, and 60.0, respectively. And the AUC areas, the specificity, and the sensitivity of level of HOTAIR for diagnosing cervical persistent HPV infection were 0.936, 84.62, and 90.00, respectively. Conclusion: The expressions of LncRNA NEAT1 and HOTAIR in exfoliated cells of patients with cervical persistent HPV infection are abnormally increased, which is positively correlated with the expression levels of p16 and Ki67, so LncRNA NEAT1 and HOTAIR levels maybe used as indicators for diagnosing patients with persistent HPV infection, which maybe used as early screening indicators for cervical cancer.

2020 Vol. 28　(2):　233- [Abstract]（ 330 ） HTML (0 KB)  PDF  (0 KB)  ( 34 )

Objective: To analyze the influence of weight gain of non-obese women with gestational diabetes mellitus (GDM) and normal blood glucose control during the second and the third trimester of pregnancy on their serum leptin and pregnancy outcomes. Methods: The non-obese women with GDM and normal blood glucose control during pregnancy were selected and divided in group A1 (women with excessive weight growth) and group B1 (women with normal weight growth) from October 2018 to April 2019. And another women with normal glucose tolerance (NGT) were selected and divided in group A2 (women with excessive weight growth) and group B2 (women with normal weight growth) during the same period. The serum leptin level and pregnancy outcomes of women were compared among the four groups. Results: The serum leptin level of women during 24-28 gestational weeks in group A1 and B1 were significant higher than that of women in group A2 and B2 (P<0.05). The serum leptin level of women during 28-32 gestational weeks in group A1 were significant higher than that of women in other three groups (P<0.05). Before delivery, the serum leptin level of women in group A1 and A2 were significant higher than that of women in group B1 and B2, and that of women in group A1 was significant higher than that of women in group B1 (P<0.05), but there was no significant different in the serum leptin level of women between group A2 and B2 (P>0.05). The rates of premature rupture of membrane and macrosomia of women in group A1 were significant higher than those of women in other three groups (P<0.05). The rate of macrosomia of women in group A1 was significant higher than that of women group A2 and B2 (P>0.05), but there was no significant different in the rate of macrosomia of women between group A1 and B1 or between group A2 and B2 (P>0.05). There was no significant different in the rate of premature rupture of membrane of women among group A2, B1 and B2 (P>0.05). There were no significant different in the rates of premature delivery and fetal distress, and neonatal Apgar score among the four groups (P>0.05).The weight gain of women in group A1 and A2 during the second and third trimester of pregnancy was correlated with the macrosomia rate, or serum leptin level during 28-32 gestational weeks and before dilevery (P<0.05), but was no correlated with the rate of premature rupture of membranes (P>0.05). Conclusion: The excessive weight gain of normal pre-pregnancy BMI women with GDM and good blood glucose control during the second and third trimester of pregnancy can increase the risk of premature rupture of membranes and macrosomia.

2020 Vol. 28　(2):　243- [Abstract]（ 385 ） HTML (0 KB)  PDF  (0 KB)  ( 41 )

Objective: To investigate the change of lipid metabolism indexes of pregnant women with gestational diabetes mellitus (GDM) during different gestatinal weeks, and to study its correlation with the rate of macrosomia. Methods: The clinical data of 200 women with GDM from January 2017 to June 2018 were retrospectively analyzed, and they were included in study group, and further divided into group A (women with macrosomia) and group B (women without macrosomia). Another 200 healthy pregnant women with normal glucose tolerance (NGT) were in control group during the same time. The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), Apolipoprotein A1 (Apo-A1), apolipoprotein (Apo-B) of women were detected and compared among these groups. Results: The levels of TC,TG,LDL-C,Apo-B of women during the first, second and third trimester of pregnancy in the study group were significant higher than those of women in the control group, but the levels of HDL-C and Apo-A1 of women in the study group were significant lower (P<0.05). The levels of TC,TG,LDL-C,Apo-B of women with macrosomia during the first, second and third trimester of pregnancy in group A were significant higher than those of women in group B, but the levels of HDL-C and Apo-A1 of women in group A were significant lower (P<0.05). The levels of TC,TG,LDL-C,Apo-B of women were significantly positively correlated with rate of macrosomia, while the levels of HDL-C and Apo-A1 were significantly negatively correlated with rate of macrosomia (P<0.05). Logistic regression analysis showed that, gain of weight (GWG), poor glycemic control, and TG level of women during the pregnancy were independent risk factors of macrosomia (P<0.05), but HDL-C and Aop-A1 levels were protective factors of avoiding macrosomia (P<0.05). Conclusion: Pregnant women with GDM have different degrees of lipid metabolism disorder, which will increase the risk of macrosomia.

2020 Vol. 28　(2):　251- [Abstract]（ 357 ） HTML (0 KB)  PDF  (0 KB)  ( 37 )

Objective: To investigate the clinical effect of leuprolide microglobulused before and after hysteromyomectomy for preventing uterine fibroids recurrence. Methods: 160 patients who had experinced laparoscopic hysteromyomectomy were selected and were divided into observation group and control group according to the order of treatment. The patients in the observation group were given leuprolide microglobulin for 3 months before hysteromyomectomy and for 1 month after operation. The patients in the control group were not given leuprolide microglobulin before and after operation. The levels of serum E2, P, FSH and LH, the operation situation, and the recurrence rate of uterine fibroids in 12 months and 24 months after operation of patients were compared between the two groups. Results: The serum E2, P, FSH and LH levels of patients in both groups had decreased significantly in 3 months after operation (P<0.05). Before and 3 months after operation, the levels of serum E2, P, FSH and LH of patients in the observation group were significant lower than those of of patients in the control group (P<0.05). The amount of intraoperative blood loss of patients in the observation group was 88.1±15.0ml, which was signifficant lower than that (100.5±18.5ml) of patients in the control group (P<0.05). There was no signifficant different in the operation time, the time out of bed for activity after operation, and the time of hospital stay of patients between the two groups (P>0.05). Conclusion: The application of leuprolide microglobulin before hysteromyomectomy can further reduce the levels of sex hormones of patients, reduce the amount of bleeding during operation, and can decrease the recurrence rate of postoperative uterine fibroids.

2020 Vol. 28　(2):　261- [Abstract]（ 410 ） HTML (0 KB)  PDF  (0 KB)  ( 37 )

Objective: To analyze the effect of vasectomy and embolization for treating postpartum hemorrhage because of uterine asthenia of women after cesarean section, and to study its influencing factors. Methods: The clinical data of 34 women with uterine artery ligation (in group A) and 40 women with uterine artery embolization (in group B) because of postpartum hemorrhage during cesarean section were analyzed retrospectively. Other normal women were included in group C. The efficacy of the two hemostasis methods was compared, and the influencing factors of hemostasis failure were analyzed. Results: There was no statistically significant different in the hemostasis success rate of women between the two groups (P>0.05). The amount of preoperative blood loss of women in group A was significant less than that of women in group B, but the operation time of women in group A was significant longer (P<0.05). Bilateral uterine artery blood flow RI by ultrasound of women in group A and B was significant more than that of women in group C (P<0.05), but that of women had no significant difference between group A and B(P>0.05). There was no significant different in bilateral uterine artery blood flow S/D of women among the three groups (P>0.05). The age, the rate of emergency cesarean section, scar uterus history, and abnormal coagulation function of women with failed hemostasis were significantly higher than those of women with successful hemostasis (P<0.05). There was no significant different in gestional weeks when delivery and the proportion of parity ≥2 times of women between group A and B (P>0.05). The emergency cesarean section, scar uterus history, and abnormal coagulation function were independent risk factors for hemostasis failure (P<0.05), but age ≥35 years old was no correlated with hemostatic failure (P>0.05). Conclusion: The success rate of uterine artery ligation used for the hemostasis and its influence on the longterm uterine artery blood flow parameters of pregnant women are similar to those of uterine artery embolization. And emergency cesarean section, scar uterus history, and abnormal coagulation function will affect the hemostatic effect by both uterine artery ligation and uterine artery embolization.

2020 Vol. 28　(2):　268- [Abstract]（ 361 ） HTML (0 KB)  PDF  (0 KB)  ( 39 )

Objective: To investigate the levels of serum calcium, phosphorus, and 25 hydroxy vitamin D (25 (OH) D) of pregnant women for predicting their postpartum hemorrhage occurance. Methods: The data of 354 pregnant women from June 2017 to June 2019 were analyzed retrospectively. 37 women with postpartum hemorrhage over 500 ml were in study group, and 317 women with postpartum hemorrhage equal to or less than 500 ml were in control group. The levels of serum calcium, phosphorus and 25 (OH) D of women in the two groups were detected before deliery. The work curve was (ROC) analysis was used to evaluate the value of the levels of serum calcium, phosphorus and 25 (OH) D for predicting postpartum hemorrhage. Results: Before delivery, the levels of serum calcium, phosphorus and 25 (OH) D of women in the study group were 2.33±0.22 mmol/L, 0.98±0.17 mmol/L, and 56.00±13.24 nmol/L, respectively, which were significant lower than those of women in the control group, but the rates of low calcium, low phosphorus, and 25 (OH) D deficiency of women in the study group were 64.9%, 21.6% and 48.7%, respectively, which were significant higher than those of women in the control group (P<0.05). The AUC of ROC curve of serum calcium and 25(OH) D levels were 0.677 (P=0.024) and 0.615 (P=0.032), respectively, which had better accuracy for predicting postpartum hemorrhage than that of serum phosphorus level. Conclusion: The levels of serum calcium, phosphorus, and 25 (OH) D of women with postpartum hemorrhage are significant lower than those of women without postpartum hemorrhage, and the serum calcium and 25 (OH) D levels of pregnant women has certain value for predicting postpartum hemorrhage occurance.

2020 Vol. 28　(2):　274- [Abstract]（ 297 ） HTML (0 KB)  PDF  (0 KB)  ( 39 )

Objective: To analyze the timing selection of placental separation of women with placenta accreta during cesarean section, and to analyze the pregnancy outcomes of women. Methods: The clinical data of 152 women with placenta accreta who underwent cesarean section from May 2017 to May 2018 were analyzed retrospectively. According to the timing of manual placenta separation, these women were divided in group A and group B. 80 women in group A had accepted placenta separation immediately after placenta accrete were found, and 72 women in group B had accepted placenta separation till uterine contraction. The changes of hemoglobin (Hb) and hematocrit (HCT) levels of women in the two groups before and after cesarean section were observed. The intraoperative bleeding amount, rate of blood transfusion, rate of B-lynch suture, and rate of special uterine contractions drugs used, rate of postoperative complications, and pregnancy outcomes of women in both groups were recorded. Results: 2 days after cesarean section, the levels of Hb and HCT of women in the two groups had decreased signifficantly (P<0.05), but those had no significant differences between the two groups (P>0.05). The intraoperative bleeding amount, the rates of B-lynch suture and special uterine contractions drugs used of women in group A were 536.4±98.6ml, 8.8%, and 21.3%, respectively, which were signifficant higher than those (346.3±55.7ml, 1.4%, and 2.8%, respectively) of women in group B (P<0.05), but there were no significant different in the number of women with blood transfusion, pregnancy outcomes, and the incidence of postoperative complications between the two groups (P>0.05). Conclusion: Compared with immediate manual placental separation of women with placenta accreta during cesarean section, removal of placenta after uterine contraction can reduce intraoperative blood loss and the special uterine contractions using, and can reduce the probability of uterine B-lynch suture.

2020 Vol. 28　(2):　280- [Abstract]（ 398 ） HTML (0 KB)  PDF  (0 KB)  ( 43 )

Objective: To explore the effect of of three-dimensional ultrasound for evaluating pelvic floor muscle function of women after vaginal delivery. Methods: 200 women after delivery were included and were divided into group A (130 women with vaginal delivery) and group B (70 women with caesarean section) from January 2017 to January 2018. And the pelvic floor muscle function of women in both groups were evaluated by three-dimensional ultrasound. Results: The resting state of posterior vesicourethral angle, the Valsalva state of posterior vesicourethral angle, the angle of the bladder neck, the mobility of the bladder neck, resting state of levator anal fissure area, hiatus area of levator anal muscle in anus constriction, the area of the hiatus in the Valsalva state, the incidence of stress urinary incontinence, the type I myofibrillar potentials, and type II myofibrillar potentials of women in group A were 126.0±8.5°,161.2±6.7°, 36.13±4.90°, 34.5±3.5mm, 13.2±2.1cm2, 11.5 + 2.0cm2, 20.4±3.3cm2, 26.15%, 8.0±1.1 V, and 8.1±1.12V, respectively, which were significant higher than those of women in group B (P<0.05). The maximum contractile force and continuous contractile force of pelvic floor muscle strength of women in group A were 36.4±8.6V and 20.1± 6.3V, which were significantly lower than those of women in group B (P<0.05). Conclusion: Three-dimensional ultrasound used to evaluate the pelvic floor function of women after vaginal delivery has good value. Vaginal delivery maybe has significant influence on the pelvic floor structure and muscle strength of women when compare to that of caesarean section.

2020 Vol. 28　(2):　288- [Abstract]（ 370 ） HTML (0 KB)  PDF  (0 KB)  ( 33 )

Early identification of the risk of intrauterine fetus during the third trimester of pregnancy can reduce fetal morbidity. Recent studies have found that uterine artery (UtA), middle cerebral artery (MCA) and ductus venosus (DV) are vital maternal or fetal blood vessels, and their changes on spectral or hemodynamic parameters of color doppler flow imaging (CDFI) can be used to predict fetal disease, such as fetal growth retardation (FGR), fetal anemia, fetal congenital heart disease (CHD), and so on, which provide the new clinical idea for evaluating uterine fetal growth and development. This review focuses on how to predict intrauterine fetal safety and dangerous based on CDFI of UtA, MCA and DV.

2020 Vol. 28　(2):　303- [Abstract]（ 417 ） HTML (0 KB)  PDF  (0 KB)  ( 38 )