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Abstract Objective: To explore the effect of different courses of metformin combined with clomiphene citrate (CC) for ovulation induction of women with polycystic ovary syndrome (PCOS). Methods: Women with PCOS were selected as subjects, and were randomly devided in group A, B, and C from January 2016 to December 2017. 34 women in group A were treated by metformin combined with CC for 12 weeks (long course), 35 women in group B were treated by metformin combined with CC for 4 weeks (short course), and 34 women in group C were treated by metformin combined with CC for 14d (ultra-short course). After six menstrual cycles followed up, the follicular development, endometrial development, cervical mucus score, and sex hormones levels of women in the three groups were observed, and the pregnancy outcomes of all women were calculated. Results: The number of mature follicles, cervical mucus score, and the endometrium thickness of women in group A and B were significant higher than those of women in group C (P<0.05). The ovulation rate (91.2%) of women in group A was highest, and the pregnancy rate (54.3%) of women in group C was highest. There were no statistical significant different in levels of serum and follicular E2, and the rate of third line markers of endometrium morphology by ultrasound of women among the three groups (P>0.05). Conclusion: The short course of metformin combined with CC can effectively promote the ovulation induction effect of PCOS women with insulin resistance and CC resistance, and can shorten the treatment period, which can be application in clinical practice.
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