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| Relationships between the levels of serum 25-Hydroxyvitamin D3 and homocysteine, and abnormal electrocardiogram of elderly pregnant women during the third trimester pregnancy and their pregnancy outcomes |
| Kunming Yan 'an Hospital, Yunnan Province, 650000 |
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Abstract Objective: To explore the relationships between levels of serum 25-Hydroxyvitamin D3(25（OH）D3) and homocysteine, and abnormal electrocardiogram (ECG) of elderly pregnant women during the third trimester pregnancy and their pregnancy outcomes. Methods: 280 pregnant women during 28-41 gestational weeks were selected and were divided in study group (140 women aged over 35 years old), and in control group (140 women aged 20-34 years old )from January 2016 to December 2017. The level of serum 25（OH）D3 of pregnant women was detected by electrochemiluminescence, the level of serum homocysteine (Hcy) of pregnant women was detected by ELISA, and the electrocardiogram of all included women was recorded by electrocardiograph. The pregnancy outcomes of women in both groups were followed up. The 25（OH）D3 and Hcy levels of women were compared between the two groups, and the relationships between the 25（OH）D3 and Hcy levels, and abnormal ECG rate of women and their pregnancy outcomes were analyzed. Results: The level of serum 25（OH）D3 of women in the study group was significant lower than that of women in the control group, but the level of Hcy of women in the study group was significant higher (P<0.05). In the study group, the level of 25（OH）D3 of women with abnormal ECG or with adverse pregnancy outcomes was significant lower, and the level of Hcy of women with abnormal ECG was significant higher (P<0.05). In the study group, the rat of abnormal ECG of women with adverse pregnancy outcomes was significant higher than that of women with good pregnancy outcomes (P<0.05). Logistic regression analysis showed that the levels of 25（OH）D3 and Hcy, and abnormal electrocardiogram were independent risk factors of adverse pregnancy outcomes of elderly pregnant women (P<0.05). Conclusion: Elderly pregnant women in the third trimester pregnancy has lower serum 25（OH）D3 level and higher Hcy level, they are easy to have abnormal ECG, so it is should be regularly detecting the levels of 25（OH）D3 and Hcy of elderly pregnant women, and monitoring their ECG.
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