|
|
|
| The influence of benzylpenicillin used in different opportunities of pregnant women with syphilis on the maternal and neonatal outcomes |
| Hanzhong 3201 Hospital Affiliated to Xi’an Jiaotong University, Shanxi Province, 723000 |
|
|
|
Abstract Objective: To explore the influence of benzylpenicillin used in different opportunities for treating pregnant women with syphilis on the maternal and neonatal outcomes of pregnant women with syphilis. Methods: The data of 151 pregnant women with syphilis who had been treated from January 2015 to January 2018 were collected. The women were divided into three groups according to benzylpenicillin used in different opportunities, which include group A (51 cases treated during less than 13+6 gestational weeks), group B (63 cases treated during 14-27+6 gestational weeks), and group C(37 cases treated during≥28 gestational weeks). The maternal and neonatal outcomes were compared among the three groups, and the titer by tolulized red unheated serum test (TRUST) of mothers and newborns were evaluated after treatment. Results: The full term delivery rate of women in group A was 96.1%, which was significant higher than that (84.1%) of women in group B and that (78.4%) of women in group C (P<0.05). The preterm birth rate of women in group A was 2.0%, which was significant lower than that (12.7%) of women in group B and that (16.2%) of women in group C (P<0.05). There were no significant different in rates of cesarean section, stillbirth or still births, and abortion among the three groups (P>0.05). The 1 min and 5 min Apgar scores of neonates in group A were significantly higher than those of neonates in group B and C (P<0.05). The incidence of neonatal asphyxia and neonatal congenital syphilis in group A was 2.0% and 2.0%, which were significant lower than those (17.5% and 12.7%) in group B and those (24.3% and 29.7%) in group C (P<0.05). There was no significant difference in the incidence of low birth weight neonates among the three groups (P>0.05). The maternal and neonatal TRUST negative rate in group A were 23.5% and 54.9%, which were significant higher than those (9.5% and 23.8%) in group B and those (5.4% and 21.6%) in group C (P<0.05).When 6 months old, the TRUST negative rate of neonates in group A, group B, and group C was 100.0%, 98.3%, and 97.1%, respectively, which had no significant different among the three groups (P>0.05). Conclusion: Benzylpenicillin can treat pregnant women with syphilis effectively. Early diagnosis and treatment is beneficial to improve maternal and neonatal outcomes and reduce the incidences of premature birth and neonatal congenital syphilis.
|
|
|
|
|
|
|
|
|
