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| Effect of dydrogesterone combined with progesterone capsules for treating women with threatened abortion because of corpus luteum dysfunction |
| The Fourth people's Hospital of Kunshan, Jiangsu province, 215300 |
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Abstract Objective: To investigate the effect of dydrogesterone combined with progesterone capsules for treating women with threatened abortion because of corpus luteum dysfunction. Methods: 80 women with threatened abortion because of corpus luteum dysfunction were enrolled as study objects, and they were randomly divided into two groups (40 cases in each group) by random numbers table. The women in the control group were treated with dydrogesterone tablets and intramuscular progesterone, and the women in the research group were treated with dydrogesterone and progesterone capsules. The efficacy and adverse reaction of women were compared between the two groups. Results: There were no significant different in the time of symptom relief and symptom disappearance of women after treatment between the two groups (P>0.05). After treatment, the levels of serum P, E2, and β-hCG of women in the two groups had increased significantly (P<0.05), but there were no significant different in the levels of serum P, E2, and β-hCG of women between the two groups(P>0.05). The success rate of spuc of women in the research group was 97.5%, which had no different to that (95.0%) of women in the control group (P>0.05). The overall incidence of adverse reactions of women in the research group was 5.0%, which was significant lower than that (25.0%) of women in the control group (P<0.05). Conclusion: Dydrogesterone combined with progesterone capsules for treating women with threatened abortion because of luteal insufficiency can quickly relieve clinical symptoms, improve progesterone level, and improve the success rate of spuc. Which’s curative effect is similar to that of dydrogesterone combined with intramuscular injection of progesterone, but the adverse reaction is less, the safety is better, and the administration is convenient.
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