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| Effect of leuprolide used before and after hysteromyomectomy for preventing uterine fibroids recurrence |
| Beijing Maternity Hospital, Capital Medical University, Beijing, 100026 |
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Abstract Objective: To investigate the clinical effect of leuprolide microglobulused before and after hysteromyomectomy for preventing uterine fibroids recurrence. Methods: 160 patients who had experinced laparoscopic hysteromyomectomy were selected and were divided into observation group and control group according to the order of treatment. The patients in the observation group were given leuprolide microglobulin for 3 months before hysteromyomectomy and for 1 month after operation. The patients in the control group were not given leuprolide microglobulin before and after operation. The levels of serum E2, P, FSH and LH, the operation situation, and the recurrence rate of uterine fibroids in 12 months and 24 months after operation of patients were compared between the two groups. Results: The serum E2, P, FSH and LH levels of patients in both groups had decreased significantly in 3 months after operation (P<0.05). Before and 3 months after operation, the levels of serum E2, P, FSH and LH of patients in the observation group were significant lower than those of of patients in the control group (P<0.05). The amount of intraoperative blood loss of patients in the observation group was 88.1±15.0ml, which was signifficant lower than that (100.5±18.5ml) of patients in the control group (P<0.05). There was no signifficant different in the operation time, the time out of bed for activity after operation, and the time of hospital stay of patients between the two groups (P>0.05). Conclusion: The application of leuprolide microglobulin before hysteromyomectomy can further reduce the levels of sex hormones of patients, reduce the amount of bleeding during operation, and can decrease the recurrence rate of postoperative uterine fibroids.
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