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Abstract Objective: To explore the curative efficacy of Sini decoction huacai combined with medroxyprogesterone acetate for treating women with endometriosis, and to study its effect on inflammatory factors and intimal blood supply of women. Methods: 75 women with endometriosis who had been diagnosed to cold coagulation and blood stasis syndrome by TCM Dialectics were selected and were divided into the study group (40 women treated with medroxyprogesterone acetate combined with Sini decoction huacai for 12 weeks) and control group (35 women treated with medroxyprogesterone acetate for 12 weeks) from January 2018 to December 2018. The clinical efficacy, TCM symptom score, serum inflammatory factors, such as tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) and IL-8, and endometrial receptivity, such as uterine artery pulsation index (PI) and resistance index (RI), and adverse reaction rate of women were compared between the two groups. Results: After treatment, the total effective rate of women in the study group was 92.5%, which was significant higher than that (74.3%) of women in the control group (P<0.05). The TCM symptom score, the levels of serum TNF-, IL-6 and IL-8, the values of uterine artery PI and RI of women in the study group were 4.3±0.4 scores, 61.0±7.2ng/L, 35.4±3.8 ng/L, 82.3±9.4ng/L, and 1.0±0.2 and 0.4±0.1, respectively, which were significant lower than those (6.2±0.6 scores, 78.54±9.3ng/L, 47.0±4.6ng/L, 103.4±10.7ng/L, and 1.33±0.2, and 0.6±0.1, respectively) of women in the control group (P<0.05). The total incidence of adverse reactions of women in the study group was 8.6%, which had no significant different to that (5.0%) of women in the control group (P>0.05). Conclusion: Sini decoction huacai combined with medroxyprogesterone acetate for treating women with endometriosis because of cold coagulation and blood stasis syndrome has good efficacy, which can effectively improve inflammation situation of women, can increase their intimal blood supply, and can promote the recovery of disease.
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